Synthesis of 2,6-diamino-5-[(2-substituted phenylamino)ethyl]pyrimidin- 4(3H)-one as inhibitors of folate metabolizing enzymes

Journal of Heterocyclic Chemistry

Volumn 43, Issue 6, 2006, Pages 1523-1531

  Gangjee, Aleem ^a   Wang, Ying ^a   Queener, Sherry F ^b   Kisliuk, Roy L ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DIAMINO 5 [(2 PHENYLAMINO)ETHYL]PYRIMIDIN 4(3H) ONE DERIVATIVE; ACETIC ACID DERIVATIVE; ANILINE DERIVATIVE; CHLOROACETALDEHYDE; CYANOACETIC ACID; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID; PIRITREXIM; TRIMETHOPRIM; TRIMETREXATE;

ARTICLE; CHEMICAL REACTION KINETICS; CYCLOCONDENSATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; FOLATE METABOLISM; IC 50; MOLECULAR MODEL; NONHUMAN; PNEUMOCYSTIS CARINII; POLYMERIZATION; REDUCTION KINETICS; SUBSTITUTION REACTION; TOXOPLASMA GONDII;

EID: 33845468182     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570430615     Document Type: Article

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