Elevated Lipoprotein(a) does not promote early atherosclerotic changes of the carotid arteries in young, healthy adults

Atherosclerosis

Volumn 190, Issue 1, 2007, Pages 194-198

  Grebe, M T ^a   Schoene, E ^a   Schaefer, C A ^a   Boedeker, R H ^b   Kemkes Matthes, B ^a   Voss, R ^a   Tillmanns, H H ^a  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

^b Institute of Medical Statistics   (Germany)

Author keywords

Cardiovascular risk; Carotid artery; Early atherosclerosis; Fibrinolysis; Intima media thickness; Lipoprotein(a); Thrombosis; Ultrasound

Indexed keywords

CHOLESTEROL; HOMOCYSTEINE; LIPOPROTEIN A; TRIACYLGLYCEROL;

ADULT; ARTERY INTIMA PROLIFERATION; ARTERY MEDIA; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BODY MASS; CARDIOVASCULAR RISK; CAROTID ARTERY OBSTRUCTION; CHOLESTEROL BLOOD LEVEL; COMMON CAROTID ARTERY; CONTROLLED STUDY; CORRELATION ANALYSIS; ECHOGRAPHY; HUMAN; LIPOPROTEIN BLOOD LEVEL; NORMAL HUMAN; PRIORITY JOURNAL; RISK FACTOR; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL; UNIVARIATE ANALYSIS;

ADULT; AGE DISTRIBUTION; BODY MASS INDEX; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CHOLESTEROL, LDL; FEMALE; HOMOCYSTEINE; HUMANS; LIPOPROTEIN(A); MALE; MIDDLE AGED; RISK FACTORS; THROMBOSIS; TRIGLYCERIDES; TUNICA INTIMA; TUNICA MEDIA;

EID: 33845465759     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2006.01.017     Document Type: Article

References (36)

1. Berg K. A new serum type system in man-the Lp system. Acta Pathol Microbiol Scand 59 (1963) 369-382
2. Scanu A.M., Nakajima K., and Edelstein C. Apolipoprotein(a): structure and biology. Front Biosci 6 (2001) D546-D554
3. Schaefer E.J., Lamon-Fava S., Jenner J.L., et al. Lipoprotein(a) levels and risk of coronary heart disease in men. The lipid Research Clinics Coronary Primary Prevention Trial. JAMA 271 (1994) 999-1003
4. Sandkamp M., Funke H., Schulte H., Kohler E., and Assmann G. Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age. Clin Chem 36 (1990) 20-23
5. Alfthan G., Pekkanen J., Jauhiainen M., et al. Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis 106 (1994) 9-19
6. Ridker P.M., Hennekens C.H., and Stampfer M.J. A prospective study of lipoprotein(a) and the risk of myocardial infarction. JAMA 270 (1993) 2195-2199
7. Ridker P.M., Stampfer M.J., and Hennekens C.H. Plasma concentration of lipoprotein(a) and the risk of future stroke. JAMA 273 (1995) 1269-1273
8. Schreiner P.J., Chambless L.E., Brown S.A., et al. Lipoprotein(a) as a correlate of stroke and transient ischemic attack prevalence in a biracial cohort: the ARIC Study. Atherosclerosis Risk in Communities. Ann Epidemiol 4 (1994) 351-359
9. Ariyo A.A., Thach C., and Tracy R. Lp(a) lipoprotein, vascular disease, and mortality in the elderly. N Engl J Med 349 (2003) 2108-2115
10. Chambless L.E., Folsom A.R., Davis V., et al. Risk factors for progression of common carotid atherosclerosis: the Atherosclerosis Risk in Communities Study, 1987-1998. Am J Epidemiol 155 (2002) 38-47
11. Greenland P., Smith Jr. S.C., and Grundy S.M. Improving coronary heart disease risk assessment in asymptomatic people: role of traditional risk factors and noninvasive cardiovascular tests. Circulation 104 (2001) 1863-1867
12. Touboul P.J., Hennerici M.G., Meairs S., et al. Mannheim intima-media thickness consensus. Cerebrovasc Dis 18 (2004) 346-349
13. Salonen R., and Salonen J.T. Progression of carotid atherosclerosis and its determinants: a population-based ultrasonography study. Atherosclerosis 81 (1990) 33-40
14. Schulz R., Seeger W., Fegbeutel C., et al. Changes in extracranial arteries in obstructive sleep apnoea. Eur Respir J 25 (2005) 69-74
15. Sramek A., Reiber J.H., Baak-Pablo R., Sturk A., and Rosendaal F.R. Lipoprotein(a) and ultrasonographically determined early atherosclerotic changes in the carotid and femoral artery. J Thromb Haemost 1 (2003) 374-379
16. Raitakari O.T., Adams M.R., and Celermajer D.S. Effect of Lp(a) on the early functional and structural changes of atherosclerosis. Arterioscler Thromb Vasc Biol 19 (1999) 990-995
17. Denti L., Marchini L., Pasolini G., et al. Lp(a) and cerebrovascular disease in the elderly: correlations with the severity of extracranial carotid atherosclerosis assessed by ultrasonography. Acta Biomed Ateneo Parmense 66 (1995) 175-183
18. Schreiner P.J., Heiss G., Tyroler H.A., et al. Race and gender differences in the association of Lp(a) with carotid artery wall thickness: the Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb Vasc Biol 16 (1996) 471-478
19. Min W.K., Lee J.O., and Huh J.W. Relation between lipoprotein(a) concentrations in patients with acute-phase response and risk analysis for coronary heart disease. Clin Chem 43 (1997) 1891-1895
20. Foody J.M., Milberg J.A., Robinson K., et al. Homocysteine and lipoprotein(a) interact to increase CAD risk in young men and women. Arterioscler Thromb Vasc Biol 20 (2000) 493-499
21. Baggio G., Donazzan S., Monti D., et al. Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors. FASEB J 12 (1998) 433-437
22. Casiglia E., Palatini P., Da Ros S., et al. Effect of blood pressure and physical activity on carotid artery intima-media thickness in stage 1 hypertensives and controls. Am J Hypertens 13 (2000) 1256-1262
23. Magyar M.T., Paragh G., Katona E., et al. Serum cholesterols have a more important role than triglycerides in determining intima-media thickness of the common carotid artery in subjects younger than 55 years of age. J Ultrasound Med 23 (2004) 1161-1169
24. Yamamoto M., Egusa G., and Yamakido M. Carotid atherosclerosis and serum lipoprotein(a) concentrations in patients with NIDDM. Diab Care 20 (1997) 829-831
25. Baldassarre D., Tremoli E., Franceschini G., Michelagnoli S., and Sirtori C.R. Plasma lipoprotein(a) is an independent factor associated with carotid wall thickening in severely but not moderately hypercholesterolemic patients. Stroke 27 (1996) 1044-1049
26. Ohkuma T., Minagawa T., Takada N., et al. C-reactive protein, lipoprotein(a), homocysteine, and male sex contribute to carotid atherosclerosis in peritoneal dialysis patients. Am J Kidney Dis 42 (2003) 355-361
27. Grainger D.J., Kemp P.R., Liu A.C., Lawn R.M., and Metcalfe J.C. Activation of transforming growth factor-beta is inhibited in transgenic apolipoprotein(a) mice. Nature 370 (1994) 460-462
28. Haque N.S., Fallon J.T., Taubman M.B., and Harpel P.C. The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpes virus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium. Blood 97 (2001) 39-45
29. Hancock M.A., Boffa M.B., Marcovina S.M., Nesheim M.E., and Koschinsky M.L. Inhibition of plasminogen activation by lipoprotein(a): critical domains in apolipoprotein(a) and mechanism of inhibition on fibrin and degraded fibrin surfaces. J Biol Chem 278 (2003) 23260-23269
30. Miles L.A., Fless G.M., Scanu A.M., et al. Interaction of Lp(a) with plasminogen binding sites on cells. Thromb Haemost 73 (1995) 458-465
31. Etingin O.R., Hajjar D.P., Hajjar K.A., Harpel P.C., and Nachman R.L. Lipoprotein(a) regulates plasminogen activator inhibitor-1 expression in endothelial cells. A potential mechanism in thrombogenesis. J Biol Chem 266 (1991) 2459-2465
32. Loscalzo J., Weinfeld M., Fless G.M., and Scanu A.M. Lipoprotein(a), fibrin binding, and plasminogen activation. Arteriosclerosis 10 (1990) 240-245
33. Caplice N.M., Panetta C., Peterson T.E., et al. Lipoprotein(a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis. Blood 98 (2001) 2980-2987
34. Martinez C., Rivera J., Loyau S., et al. Binding of recombinant apolipoprotein(a) to human platelets and effect on platelet aggregation. Thromb Haemost 85 (2001) 686-693
35. Tsimikas S., Brilakis E.S., Miller E.R., et al. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med 353 (2005) 46-57
36. Fuster V., Badimon J., Chesebro J.H., and Fallon J.T. Plaque rupture, thrombosis, and therapeutic implications. Haemostasis 26 Suppl. 4 (1996) 269-284