Binding of recombinant apolipoprotein(a) to human platelets and effect on platelet aggregation

Thrombosis and Haemostasis

Volumn 85, Issue 4, 2001, Pages 686-693

  Martinez C ^a   Rivera, J ^a   Loyau, S ^a   Corral, J ^a   Gonzalez Conejero R ^a   Lozano, M L ^a   Vicente, V ^a   Angles Cano E ^a  

^a HOSPITAL UNIVERSITARIO MORALES MESEGUER   (Spain)

Author keywords

Apolipoprotein(a) binding sites; Platelet aggregation; Platelet receptors

Indexed keywords

AMINOCAPROIC ACID; APOLIPOPROTEIN A; APOLIPOPROTEIN B100; ARACHIDONIC ACID; FIBRIN; FIBRINOGEN; FIBRINOGEN RECEPTOR; ISOPROTEIN; LIPOPROTEIN A; LYSINE DERIVATIVE; MONOCLONAL ANTIBODY; PLASMINOGEN; PROTEIN SUBUNIT; RECOMBINANT PROTEIN; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CELL SURFACE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FIBRIN POLYMERIZATION; HUMAN; HUMAN CELL; INCUBATION TIME; METABOLIC INHIBITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; RECEPTOR BINDING; SCATCHARD PLOT; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOSIS;

EID: 0035070810     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615654     Document Type: Article

References (44)

1. Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography
2. Lp(a) lipoprotein as a risk factor for myocardial infarction
3. Relation of serum lipoprotein(a) and apoliporotein(a) phenotype to coronary heart disease with familial hypercholesterolemia
4. Quantification of apo(a) and apoB in human atherosclerotic lesions
5. Immunochemically detectable lipid-free apo(a) in plasma and in human atherosclerotic lesions
6. 4057 of apolipoprotein(a) is essential for lipoprotein(a) assembly
7. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
8. Molecular definition of the extreme size polymorphism in apolipoprotein(a)
9. Identification of two functionally lysine-binding sites in kringle 37 and kringles 32-36 of human apolipoprotein(a)
10. Expression and purification of kringle-4-type-2 of human apolipoprotein(a) in Escherichia coli
11. Lipoprotein(a) fibrin binding and plasminogen activation
12. Apolipoprotein(a) and plasminogen interactions with fibrin: A study with recombinant apolipoprotein(a) and isolated plasminogen fragments
13. A potential basis for the thrombotic risks associated with lipoprotein(a)
14. Lipoprotein(a) isoforms display differences in affinity for plasminogen-like binding to human mononuclear cells
15. Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis
16. Lipoprotein(a) binds to human platelets and attenuates plasminogen binding and activation
17. Identification of glycoprotein IIb as the lipoprotein(a)binding protein on platelets. Lipoprotein(a) binding is independent of an arginyl-glycyl-aspartate tripeptide located in apolipoprotein(a)
18. Lipoprotein(a) inhibits collagen-induced aggregation of thrombocytes
19. Lysine modification of LDL or lipoprotein(a) by 4-hydroxynonenal or malondialdehyde decreases platelet serotonin secretion without affecting platelet aggregability and eicosanoid formation
20. 3 (GPIIb-IIIa) is not implicated in the binding of LDL to intact resting platelets
21. Apolipoprotein(a) enhances platelet responses to the thrombin receptor-activating peptide SFLLRN
22. The number of identical kringle IV repeats in apolipoprotein(a) affects its processing and secretion by HepG2 cells
23. A novel kringle-4 number-based recombinant apo(a) standard for human apo(a) phenotyping
24. Plasminogen: Purification from human plasma by affinity chromatography
25. The preparation and some properties of fibrinogen precipitated from human plasma with glycine
26. Characterization of the binding of plasminogen to fibrin surfaces: The role of carboxy-terminal lysines
27. 308 → Lys) does not affect the binding of t-PA and plasminogen to fibrin
28. Cleavage of structural proteins during the assembly the head of bacteriophage T4
29. Preparation of suspensions of washed platelets from humans
30. a-di phenylglycoluril
31. LIGAND: A versatile computerized approach for the characterization of ligand binding systems
32. Analysis of radioligand binding experiments: A collection of computer programs for the IBM PC
33. Numbers of receptor sites from Scatchard graphs: Facts and fantasies
34. Lipoprotein(a). A unique risk factor for atherothrombotic disease
35. Platelets and the lipoproteins: Naive, modified and platelet modified lipoproteins
36. Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease
37. Competition between plasminogen and tissue plasminogen activator for cellular binding sites
38. Ligand-induced conformation change of lipoprotein(a)
39. Plasminogen interactis with human platelets through two distinct mechanisms
40. Plasminogen interactions with platelets in plasma
41. Characterization of the binding of human tissue-type plasminogen activator to platelets
42. Microenvironment changes in human blood platelet membranes associated with binding of tissue-type plasminogen activator
43. Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides
44. Essential groups in synthetic agonist peptides for activation and the platelet thrombin receptor