Microwave-assisted "green" synthesis of 2-alkyl/ arylbenzothiazoles in one pot: A facile approach to anti-tumor drugs

Journal of Heterocyclic Chemistry

Volumn 43, Issue 6, 2006, Pages 1609-1612

  Kamila, Sukanta ^a   Koh, Benjamin ^a   Biehl, Edward R ^a  

^a SOUTHERN METHODIST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3,4,5 TRIMETHOXYPHENYL)BENZO[D]THIAZOLE; 2 (4 METHOXYPHENYL)BENZO[D]THIAZOLE; 2 (4 TOLYLBENZO[D]THIAZOLE); 2 (FURAN 2 YL)BENZO[D]THIAZOLE; 2 (NAPHTHALEN 2 YL)BENZO[D]THIAZOLE; 2 ISOPROPYLBENZO[D]THIAZOLE; 2 PHENYLBENZO[D]THIAZOLE; 2 TERT BUTYL 6 CHLOROBENZO[D]THIAZOLE; 2 TERT BUTYLBENZO[D]THIAZOLE; 4 (BENZO[D]THIAZOL 2 YL)BENZONITRILE; 6 CHLORO 2 (3 METHOXYPHENYL)BENZO[D]THIAZOLE; 6 CHLORO 2 (4 FLUOROPHENYL)BENZO[D]THIAZOLE; 6 CHLORO 2 (4 METHOXYPHENYL)BENZO[D]THIAZOLE; 6 CHLORO 2 (NAPHTHALEN 2 YL)BENZO[D]THIAZOLE; 6 CHLORO 2 PHENYLBENZO[D]THIAZOLE; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; DRUG SYNTHESIS; MICROWAVE IRRADIATION; PROTON NUCLEAR MAGNETIC RESONANCE; TEMPERATURE;

EID: 33845457495     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570430627     Document Type: Article

References (20)

1. A. L. Loaiza-Perez, V. Trapani, C. Hose, S. S. Singh, J. Trepel, M. F. G. Stevens, T. D. Bradshaw, E. A. Sausville, Mol. Pharmacol., 2002, 61, 13;
2. V. Trapani, V. Patel, H. P. Ciolina, G. C. Yeh, C. Hose, J. B. Trepel, M. F. G. Stevens, E. A. Sausville, A. L. Loaiza-Perez, Br. J. Cancer, 2003, 88, 599.
3. G. Wells, J. M. Berry, T. D. Bradshaw, A. M. Burger, A. Seaton, B. Wang, A. D. Westwell, M. F. G. Stevens, J. Med. Chem., 2003, 46, 532;
4. J. M. Berry, T. D. Bradshaw, I. Fichtner, R. Ren, C. H. Schwalbe, G. Wells, E. H. Chew, M. F. G. Stevens, A. D. Westwell, J. Med. Chem., 2005, 48, 639.
5. T. D. Bradshaw, C. S. Matthew, J. Cookson, E. H. Chew, M. Shah, K. Bailey, A. Monks, E. Harris, A. D. Westwell, G. Wells, G. A. Laughton, M. F. G. Stevens, Cancer Res., 2005, 65, 3911;
6. A. Mukherjee, T. D. Bradshaw, A. D. Westwell, M. F. G. Stevens, J. Carmichael, G. G. Martin, Br. J. Cancer, 2005, 92, 350.
7. T. D. Bradsaw, A. D. Westwell, Curr. Med. Chem., 2004, 11, 1241.
8. I. Fichtner, A. Monks, C. Hose, M. F. G. Stevens, T. D. Bradshaw, Breast Cancer Res. Treat., 2004, 87, 97.
9. R. D. Haugwitz, R. G. Angel, G. A. Jacobs, B. V. Maurer, V. L. Narayanan, L. R. Cruthers, J. Szanto, J. Med. Chem., 1982, 25, 969.
10. C. Benedi, F. Bravo, P. Uriz, E. Fernandez, C. Claver, S. Castillon, Tetrahedron Lett., 2003, 44, 6073.
11. B. George, E. P. Papadopoulos, J. Org. Chem., 1977, 3, 441.
12. A. K. Chaekrabooti, C. Selram, G. Kaur, S. Bhagat, Synlett, 2004, 5, 851.
13. S. Kamila, H. M. Zhang, E. R. Biehl, Heterocycles, 2005, 65, 2119.
14. A. Loupy, Ed, Microwaves in Organic Synthesis, Wiley-VCH, New York, 2003;
15. P. Lidstrom, J. Tierney, B. Wathey, J. Westman, Tetrahedron, 2001, 57, 9225;
16. N. Elander, J. R. Jones, S. Y. Lu, S. Stone-Elander, Chem. Soc. Rev., 2000, 4, 239;
17. R. S. Varma, Green Chem., 1999, 1, 43;
18. H. M. Kingston, S. J. Haswell, Ed, Microwave-Enhanced Chemistry: Fundamentals, Sample Preparation, and Applications, American Chemical Society, Washington D. C., 1997.
19. D. N. Ridge, J. W. Hanifin, L. A. Harten, B. D. Johnson, J. Menschik, G. Nicolaus, A. E. Slobada, D. E. Watts, J. Med. Chem., 1979, 22, 1385;
20. J. C. Lee, Y. H. Bae, S. K. Chang, Bull. Korean Chem. Soc. 2003, 24, 407.