Heterogeneity of glycinergic and gabaergic interneurons in the granule cell layer of mouse cerebellum

Journal of Comparative Neurology

Volumn 500, Issue 1, 2007, Pages 71-83

  Simat, Marija ^a   Parpan, Franzisica ^a   Fritsch, Jean Marc ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Enhanced GFP; GABA; Glycine; Interneurons; Transgenic mice

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; CELL MARKER; GLYCINE RECEPTOR; GREEN FLUORESCENT PROTEIN; METABOTROPIC RECEPTOR 2; NEUROGRANIN; NEUROTRANSMITTER; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL HETEROGENEITY; CELL LABELING; CELL SIZE; CELL STRUCTURE; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; CEREBELLUM; CONTROLLED STUDY; DENDRITE; GRANULE CELL; GRANULE CELL LAYER; IMMUNOFLUORESCENCE TEST; INNERVATION; INTERNEURON; MOUSE; NERVE CELL CULTURE; NERVE FIBER; NEUROCHEMISTRY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; AXONS; CELL DIFFERENTIATION; CEREBELLUM; FLUORESCENT ANTIBODY TECHNIQUE; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; GLYCINE; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; GREEN FLUORESCENT PROTEINS; INTERNEURONS; ISOENZYMES; MICE; MICE, TRANSGENIC; MODELS, ANATOMIC; NERVE TISSUE PROTEINS;

EID: 33845451608     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.21142     Document Type: Article

References (38)

1. Aoki E, Semba R, Kashiwamata S. 1986. New candidates for GABAergic neurons in the rat cerebellum: an immunocytochemical study with anti-GABA antibody. Neurosci Lett 68:267-271.
2. Bastianelli E. 2003. Distribution of calcium-binding proteins in the cereH bellum. Cerebellum 2:242-262.
3. Celio MR. 1990. Calbindin D-28k and parvalbumin in the rat nervous system. Neuroscience 35:375-475.
4. Dean I, Robertson SJ, Edwards FA. 2003. Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar Purkinje cells: a Lugaro cell to Purkinje cell synapse. J Neurosci 23:4457-4469.
5. Dieudonne S, Dumoulin A. 2000. Serotonin-driven long-range inhibitory connections in the cerebellar cortex. J Neurosci 20:1837-1348.
6. Dugue GP, Dumoulin A, Triller A, Dieudonne S. 2005. Target-dependent use of coreleased inhibitory transmitters at central synapses. J Neurosci 25:6490-6498.
7. Dumoulin A, Triller A, Dieudonne S. 2001. IPSC kinetics at identified GABAergic and mixed GABAergic and glycinergic synapses onto cerebellar Golgi cells. J Neurosci 21:6045-6057.
8. A-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol 359:154-194.
9. A receptors containing the α1 subunit in Purkinje cells. J Neurosci 26:3245-3255.
10. Gabbott PLA, Somogyi J, Stewart MG, Hamori J. 1986. GABA-immunoreactive neurons in the rat cerebellum: a light and electron microscope study. J Comp Neurol 251:474-490.
11. Gerendasy DD, Sutcliffe JG. 1997. RC3/neurogranin, a postsynaptic calpacitin for setting the response threshold to calcium influxes. Mol Neurobiol 15:131-163.
12. Geurts FJ, Timmermans JP, Shigemoto R, De Schutter E. 2001. Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum. Neuroscience 104:499.
13. Geurts FJ, de Schutter E, Dieudonne S. 2003. Unraveling the cerebellar cortex: cytology and cellular physiology of large-sized interneurons in the granular layer. Cerebellum 2:290-299.
14. + channel, in migrating Purkinje cells and other post-migratory cerebellar neurons. Eur J Neurosci 18:601-612.
15. Huang KP, Huang FL, Jäger T, Li JH, Reymann KG, Balschung D. 2004. Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling. J Neurosci 24:10660-10669.
16. Kaneda M, Farrant M, Cull-Candy SG. 1995. Whole-cell and single-channel currents activated by GABA and glycine in granule cells of the rat cerebellum. J Physiol (Lond) 485:419-435.
17. Laine J, Axelrad H. 1996. Morphology of the Golgi-impregnated Lugaro cell in the rat cerebellar cortex: a reappraisal with a description of its axon. J Comp Neurol 375:618-640.
18. Laine J, Axelrad H. 1998. Lugaro cells target basket and stellate cells in the cerebellar cortex. Neuroreport 9:2399-2403.
19. Laine J, Axelrad H. 2002. Extending the cerebellar Lugaro cell class. Neuroscience 115:363-374.
20. Meguro R, Ohishi H, Hoshino K, Hicks TP, Norita M. 1999. Metabotropic glutamate receptor 2/3 immunoreactivity in the developing rat cerebellar cortex. J Comp Neurol 410:243-255.
21. Mitchell SJ, Silver RA. 2000. Glutamate spillover suppresses inhibition by activating presynaptic mGluRs. Nature 404:498-502.
22. Mugnaini E, Floris A. 1994. The unipolar brush cell: a neglected neuron of the mammalian cerebral cortex. J Comp Neurol 339:174-180.
23. Negyessy L, Vidnyanszky Z, Kuhn R, Knöpfel T, Göres TJ, Hamori J. 1997. Light and electron microscopic demonstration of mGluR5 metabotropic glutamate receptor immunoreactive neuronal elements in the rat cerebellar cortex. J Comp Neurol 385:641-650.
24. Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1996. Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations of Golgi cells in the rat cerebellum. Neuroscience 75:815-826.
25. Ohishi H, Ogawameguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. 1994. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron 13:55-66.
26. Ottersen OP, Storm-Mathisen J. 1984. Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique. J Comp Neurol 229:374-392.
27. Ottersen OP, Storm-Mathisen J, Somogyi P. 1988. Colocalization of glycine-like and GABA-like immunoreactivities in Golgi cell terminals in the rat cerebellum: a postembedding light and electron microscopic study. Brain Res 450:342-353.
28. Palay SL, Chan-Palay V. 1974. Cerebellar cortex: cytology and organization. New York: Springer-Verlag.
29. Pin JP, Duvoisin R. 1995. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34:1-26.
30. Sahin M, Hockfield S. 1990. Molecular identification of the Lugaro cell in the rat cerebellar cortex. J Comp Neurol 301:575-584.
31. Singec I, Knoth R, Ditter M, Frotscher M, Volk B. 2003. Neurogranin expression by cerebellar neurons in rodents and non-human primates. J Comp Neurol 459:278-289.
32. Slemmon JR, Feng B, Erhardt JA. 2000. Small proteins that modulate calmodulin-dependent signal transduction: effects of PEP-19, neuromodulin, and neurogranin on enzyme activation and cellular homeostasis. Mol Neurobiol 22:99-113.
33. Takamori S, Riedel D, Jahn R. 2000. Immunoisolation of GABA-specific synaptic vesicles defines a functionally distinct subset of synaptic vesicles. J Neurosci 20:4904-4911.
34. Tamamaki N, Yanagawa Y, Tomioka R, Miyazaki J, Obata K, Kaneko T. 2003. Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. J Comp Neurol 467:60-79.
35. Vincent SR, McIntosh CH, Buchan AM, Brown JC. 1985. Central somatostatin systems revealed with monoclonal antibodies. J Comp Neurol 238:169-186.
36. Watanabe D, Nakanishi S. 2003. mGluR2 postsynaptically senses granule cell inputs at Golgi cell synapses. Neuron 39:821-829.
37. Watanabe D, Inokawa H, Hashimoto K, Suzuki N, Kano M, Shigemoto R, Hirano T, Toyama K, Kaneko S, Yokoi M, Moriyoshi K, Suzuki M, Kobayashi K, Nagatsu T, Kreitman RJ, Pastan I, Nakanishi S. 1998. Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell 95:17-27.
38. Zeilhofer HR, Studler B, Arabadzisz D, Schweizer C, Ahmadi S, Layh B, Bösl MR, Fritschy JM. 2005. Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice. J Comp Neurol 482:123-141.