Early Short-Term Platelet-Derived Growth Factor Inhibition Prevents the Development of Chronic Allograft Nephropathy in Experimental Rat Kidney Transplantation

Transplantation Proceedings

Volumn 38, Issue 10, 2006, Pages 3231-3232

  Savikko, J ^a,b   Rintala, J ^a   von Willebrand, Eva ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b PÄIJÄT HÄME CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; IMATINIB; IMMUNOSUPPRESSIVE AGENT; MITOGENIC AGENT; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHRONIC ALLOGRAFT DAMAGE INDEX; CHRONIC ALLOGRAFT NEPHROPATHY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; KIDNEY FUNCTION; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MESENCHYME CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; RATING SCALE;

ANIMALS; CYCLOSPORINE; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MODELS, ANIMAL; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, INBRED WF; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC;

EID: 33845443246     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.10.083     Document Type: Article

References (10)

1. Halloran P.F., Melk A., and Barth C. Rethinking chronic allograft nephropathy: the concept of accelerated senescence. J Am Soc Nephrol 10 (1999) 167
2. Paul L.C. Chronic allograft nephropathy-a model of impaired repair from injury?. Nephrol Dial Transplant 15 (2000) 149
3. Li X., and Eriksson U. Novel PDGF family members: PDGF-C and PDGF-D. Cytokine Growth Factor Rev 14 (2003) 91
4. Fellström B., Klareskog L., Heldin C.H., et al. Platelet-derived growth factor receptors in the kidney-upregulated expression in inflammation. Kidney Int 36 (1989) 1099
5. Floege J., Hudkins K.L., Davis C.L., et al. Expression of PDGF alpha-receptor in renal arteriosclerosis and rejecting renal transplants. J Am Soc Nephrol 9 (1998) 211
6. Savikko J., Taskinen E., and von Willebrand E. Chronic allograft nephropathy is prevented by inhibition of platelet-derived growth factor receptor: tyrosine kinase inhibitors as a potential therapy. Transplantation 75 (2003) 1147
7. Buchdunger E., Cioffi C.L., Law N., et al. Abl protein-tyrosine kinase inhibitor ST1571 inhibits in vitro signal transduction mediated by c-Kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 295 (2000) 139
8. Druker B.J., Talpaz M., Resta D.J., et al. Efficacy and safety of a spesific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344 (2001) 1031
9. Joensuu H., Roberts P.J., Sarlomo-Rikala M., et al. Effect of tyrosine kinase inhibitor ST1571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 344 (2001) 1052
10. Savikko J., Kallio E.A., Taskinen E., et al. The effect of acute rejection and CsA-treatment on induction of PDGF and its receptors in the development of chronic rat renal allograft rejection. Transplantation 73 (2002) 506