Endothelial Nitric Oxide Synthase Protects Transplanted Mouse Livers Against Storage/Reperfusion Injury: Role of Vasodilatory and Innate Immunity Pathways

Transplantation Proceedings

Volumn 38, Issue 10, 2006, Pages 3351-3357

  Theruvath, T P ^a   Zhong, Z ^a   Currin, R T ^a   Ramshesh, V K ^a   Lemasters, J J ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUORESCEIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRYOPRESERVATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; LIVER INJURY; LIVER NECROSIS; LIVER PRESERVATION; LIVER TRANSPLANTATION; MACROPHAGE; MALE; MICROCIRCULATION; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; VASODILATATION; WILD TYPE;

ANIMALS; IMMUNITY, NATURAL; LIVER CIRCULATION; LIVER TRANSPLANTATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROCIRCULATION; NITRIC OXIDE SYNTHASE TYPE III; ORGAN PRESERVATION; REPERFUSION INJURY; VASODILATION;

EID: 33845443242     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.10.171     Document Type: Article

References (12)

1. Lemasters J.J., and Thurman R.G. Reperfusion injury after liver preservation for transplantation. Annu Rev Pharmacol Toxicol 37 (1997) 327
2. Vollmar B., Glasz J., Leiderer R., et al. Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion. Am J Pathol 145 (1994) 1421
3. Yagnik G.P., Takahashi Y., Tsoulfas G., et al. Blockade of the L-arginine/NO synthase pathway worsens hepatic apoptosis and liver transplant preservation injury. Hepatology 36 (2002) 573
4. Hines I.N., Harada H., Flores S., et al. Endothelial nitric oxide synthase protects the post-ischemic liver: potential interactions with superoxide. Biomed Pharmacother 59 (2005) 183
5. Kim J.S., Ohshima S., Pediaditakis P., et al. Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition. Hepatology 39 (2004) 1533
6. Zwacka R.M., Zhou W., Zhang Y., et al. Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-kappaB activation. Nat Med 4 (1998) 698
7. Taniai H., Hines I.N., Bharwani S., et al. Susceptibility of murine periportal hepatocytes to hypoxia-reoxygenation: role for NO and Kupffer cell-derived oxidants. Hepatology 39 (2004) 1544
8. Jaeschke H. Mechanisms of reperfusion injury after warm ischemia of the liver. J Hepatobiliary Pancreat Surg 5 (1998) 402
9. Kupiec-Weglinski J.W., and Busuttil R.W. Ischemia and reperfusion injury in liver transplantation. Transplant Proc 37 (2005) 1653
10. Connelly L., Madhani M., and Hobbs A.J. Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo. J Biol Chem 280 (2005) 10040
11. Conzelmann LO, Lehnert M, Kremer M, et al: Graft tumor necrosis factor receptor 1 protects after mouse liver transplantation whereas host TNFR1 promotes injury. Transplantation (in press)
12. Lemasters J.J. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am J Physiol 276 (1999) G1