A novel one-pot synthesis of N,6-disubstituted 1,3,5-triazine-4,6-diamines from isothiocyanates and amidines

Tetrahedron Letters

Volumn 48, Issue 3, 2007, Pages 435-437

  Liu, Chunjian ^a   Lin, James ^a   Leftheris, Katerina ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 DIMETHYLAMINOPROPYL) 3 ETHYLCARBODIIMIDE; 1,3,5 TRIAZINE 4,6 DIAMINE; AMIDINE; DIAMINE DERIVATIVE; ISOTHIOCYANIC ACID; SODIUM HYDROGEN CYANAMIDE; TRIAZINE DERIVATIVE;

ARTICLE; COOLING; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HEATING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ONE POT SYNTHESIS; REACTION ANALYSIS; STRUCTURE ANALYSIS; VACUUM;

EID: 33845434800     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.11.069     Document Type: Article

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11. 6) δ: 170.5, 167.4, 164.8, 152.9, 137.1, 136.4, 132.9, 131.8, 128.6, 128.1, 98.0, 60.4, 56.1.
12. 6) δ: 170.7, 167.6, 136.9, 135.4, 131.8, 129.6, 129.5, 129.2, 128.9, 128.7, 128.2, 127.8.
13. 6) δ: 170.6, 167.5, 165.0, 140.3, 137.1, 131.8, 128.8, 128.6, 128.1, 122.3, 120.3.
14. 6) δ: 169.9, 167.8, 167.5, 164.9, 140.2, 139.6, 137.1, 128.8, 127.9, 127.8, 122.4, 120.3.
15. 2O-0.1% TFA; Gradient time: 4 min; Detecting wavelength: 254 nm.
16. 6) δ: 182.4, 167.2, 164.8, 153.0, 136.6, 132.8, 98.0, 60.6, 56.2, 39.8, 21.3.
17. 6) δ: 184.4, 167.1, 164.6, 152.8, 136.6, 132.6, 97.7, 60.4, 56.0, 38.8, 29.2.
18. 6) δ: 159.9, 153.1, 134.4, 134.0, 117.7, 100.1, 60.4, 56.1.
19. Iwanowicz E.J., Watterson S.H., Liu C., Gu H., Mitt T., Leftheris K., Barrish J.C., Fleener C.A., Rouleau K., Sherbina N.Z., and Hollenbaugh D.L. Bioorg. Med. Chem. Lett. 12 (2002) 2931-2934