Early voluntary exercise does not promote healing in a rat model of Achilles tendon injury

Journal of Applied Physiology

Volumn 101, Issue 6, 2006, Pages 1720-1726

  Godbout, Charles ^a   Ang, Oliver ^a   Frenette, Jérôme ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Collagen; Exercise; Macrophage; Mechanical stress; Neutrophil

Indexed keywords

COLLAGEN; COLLAGENASE; HYDROXYPROLINE;

ACHILLES TENDON RUPTURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL SUBPOPULATION; CONTROLLED STUDY; EDEMA; FORCE; HEALING; INFLAMMATORY CELL; MACROPHAGE; MALE; MECHANICAL STRESS; MECHANICS; MOBILIZATION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; RIGIDITY; TREADMILL EXERCISE;

ANIMALS; DISEASE MODELS, ANIMAL; EXERCISE THERAPY; EXERTION; MACROPHAGE ACTIVATION; MALE; MECHANOTRANSDUCTION, CELLULAR; NEUTROPHIL ACTIVATION; RATS; RATS, WISTAR; STRESS, MECHANICAL; TENDON INJURIES; TREATMENT OUTCOME; VOLITION; WOUND HEALING;

EID: 33845430415     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00301.2006     Document Type: Article

References (49)

1. Bailon-Plaza A, van der Meulen MC. Beneficial effects of moderate, early loading and adverse effects of delayed or excessive loading on bone healing. J Biomech 36: 1069-1077, 2003.
2. Buchanan CI, Marsh RL. Effects of exercise on the biomechanical, biochemical and structural properties of tendons. Comp Biochem Physiol A Mol Integr Physiol 133: 1101-1107, 2002.
3. Carter DR, Beaupre GS, Giori NJ, Helms JA. Mechanobiology of skeletal regeneration. Clin Orthop Relat Res S41-S55, 1998.
4. Chan YS, Li Y, Foster W, Horaguchi T, Somogyi G, Fu FH, Huard J. Antifibrotic effects of suramin in injured skeletal muscle after laceration. J Appl Physiol 95: 771-780, 2003.
5. Chao EY, Inoue N. Biophysical stimulation of bone fracture repair, regeneration and remodelling. Eur Cell Mater 6: 72-84; discussion 84-75, 2003.
6. Chiquet M, Renedo AS, Huber F, Fluck M. How do fibroblasts translate mechanical signals into changes in extracellular matrix production? Matrix Biol 22: 73-80, 2003.
7. Davidson CJ, Ganion LR, Gehlsen GM, Verhoestra B, Roepke JE, Sevier TL. Rat tendon morphologic and functional changes resulting from soft tissue mobilization. Med Sci Sports Exerc 29: 313-319, 1997.
8. Desmouliere A, Chaponnier C, Gabbiani G. Tissue repair, contraction, and the myofibroblast. Wound Repair Regen 13: 7-12, 2005.
9. Dovi JV, He LK, DiPietro LA. Accelerated wound closure in neutrophil-depleted mice. J Leukoc Biol 73: 448-455, 2003.
10. Eckes B, Krieg T. Regulation of connective tissue homeostasis in the skin by mechanical forces. Clin Exp Rheumatol 22: S73-S76, 2004.
11. Foster W, Li Y, Usas A, Somogyi G, Huard J. Gamma interferon as an antifibrosis agent in skeletal muscle. J Orthop Res 21: 798-804, 2003.
12. Fukushima K, Badlani N, Usas A, Riano F, Fu F, Huard J. The use of an antifibrosis agent to improve muscle recovery after laceration. Am J Sports Med 29: 394-402, 2001.
13. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 200: 500-503, 2003.
14. Goodship AE, Cunningham JL, Kenwright J. Strain rate and timing of stimulation in mechanical modulation of fracture healing. Clin Orthop Relat Res S105-S115, 1998.
15. Goodship AE, Kenwright J. The influence of induced micromovement upon the healing of experimental tibial fractures. J Bone Joint Surg Br 67: 650-655, 1985.
16. Hamill OP, Martinac B. Molecular basis of mechanotransduction in living cells. Physiol Rev 81: 685-740, 2001.
17. Henson PM, Vandivier RW. The matrix degrades, neutrophils invade. Nat Med 12: 280-281, 2006.
18. Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev 84: 649-698, 2004.
19. Koskinen SO, Heinemeier KM, Olesen JL, Langberg H, Kjaer M. Physical exercise can influence local levels of matrix metalloproteinases and their inhibitors in tendon-related connective tissue. J Appl Physiol 96: 861-864, 2004.
20. Lester GE. Summary-tendon biology. J Musculoskelet Neuronal Interact 3: 333-334, 2003.
21. Lin TW, Cardenas L, Soslowsky LJ. Biomechanics of tendon injury and repair. J Biomech 37: 865-877, 2004.
22. Magnusson SP, Hansen P, Kjaer M. Tendon properties in relation to muscular activity and physical training. Scand J Med Sci Sports 13: 211-223, 2003.
23. Marsolais D, Cote CH, Frenette J. Neutrophils and macrophages accumulate sequentially following Achilles tendon injury. J Orthop Res 19: 1203-1209, 2001.
24. Marsolais D, Cote CH, Frenette J. Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration. Lab Invest 83: 991-999, 2003.
25. Martin P, Leibovich SJ. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol 15: 599-607, 2005.
26. Massimino ML, Rapizzi E, Cantini M, Libera LD, Mazzoleni F, Arslan P, Carraro U. ED2+ macrophages increase selectively myoblast proliferation in muscle cultures. Biochem Biophys Res Commun 235: 754-759, 1997.
27. McLennan IS. Resident macrophages (ED2- and ED3-positive) do not phagocytose degenerating rat skeletal muscle fibres. Cell Tissue Res 272: 193-196, 1993.
28. McNeilly CM, Banes AJ, Benjamin M, Ralphs JR. Tendon cells in vivo form a three dimensional network of cell processes linked by gap junctions. J Anat 189: 593-600, 1996.
29. Murrell GA, Jang D, Deng XH, Hannafin JA, Warren RF. Effects of exercise on Achilles tendon healing in a rat model. Foot Ankle Int 19: 598-603, 1998.
30. Nabeshima Y, Grood ES, Sakurai A, Herman JH. Uniaxial tension inhibits tendon collagen degradation by collagenase in vitro. J Orthop Res 14: 123-130, 1996.
31. Nakatani T, Marui T, Hitora T, Doita M, Nishida K, Kurosaka M. Mechanical stretching force promotes collagen synthesis by cultured cells from human ligamentum flavum via transforming growth factor-beta1. J Orthop Res 20: 1380-1386, 2002.
32. Negishi S, Li Y, Usas A, Fu FH, Huard J. The effect of relaxin treatment on skeletal muscle injuries. Am J Sports Med 33: 1816-1824, 2005.
33. Petersen W, Varoga D, Zantop T, Hassenpflug J, Mentlein R, Pufe T. Cyclic strain influences the expression of the vascular endothelial growth factor (VEGF) and the hypoxia inducible factor 1 alpha (HIF-1alpha) in tendon fibroblasts. J Orthop Res 22: 847-853, 2004.
34. Prajapati RT, Chavally-Mis B, Herbage D, Eastwood M, Brown RA. Mechanical loading regulates protease production by fibroblasts in three-dimensional collagen substrates. Wound Repair Regen 8: 226-237, 2000.
35. Probst A, Palmes D, Freise H, Langer M, Joist A, Spiegel HU. A new clamping technique for biomechanical testing of tendons in small animals. J Invest Surg 13: 313-318, 2000.
36. Radi ZA, Khan NK. Effects of cyclooxygenase inhibition on bone, tendon, and ligament healing. Inflamm Res 54: 358-366, 2005.
37. Ralphs JR, Benjamin M, Waggett AD, Russell DC, Messner K, Gao J. Regional differences in cell shape and gap junction expression in rat Achilles tendon: relation to fibrocartilage differentiation. J Anat 193: 215-222, 1998.
38. Ruberti JW, Hallab NJ. Strain-controlled enzymatic cleavage of collagen in loaded matrix. Biochem Biophys Res Commun 336: 483-489, 2005.
39. Schild C, Trueb B. Mechanical stress is required for high-level expression of connective tissue growth factor. Exp Cell Res 274: 83-91, 2002.
40. Screen HR, Shelton JC, Bader DL, Lee DA. Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles. Biochem Biophys Res Commun 336: 424-429, 2005.
41. See EK, Ng GY, Ng CO, Fung DT. Running exercises improve the strength of a partially ruptured Achilles tendon. Br J Sports Med 38: 597-600, 2004.
42. Sharma P, Maffulli N. Tendon injury and tendinopathy: healing and repair. J Bone Joint Surg Am 87: 187-202, 2005.
43. Wang JH. Mechanobiology of tendon. J Biomech 39: 1563-1582, 2006.
44. Weathington NM, van Houwelingen AH, Noerager BD, Jackson PL, Kraneveld AD, Galin FS, Folkerts G, Nijkamp FP, Blalock JE. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med 12: 317-323, 2006.
45. Woessner JF Jr. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 93: 440-447, 1961.
46. Wren TA, Lindsey DP, Beaupre GS, Carter DR. Effects of creep and cyclic loading on the mechanical properties and failure of human Achilles tendons. Ann Biomed Eng 31: 710-717, 2003.
47. Yang G, Crawford RC, Wang JH. Proliferation and collagen production of human patellar tendon fibroblasts in response to cyclic uniaxial stretching in serum-free conditions. J Biomech 37: 1543-1550, 2004.
48. Yang G, Im HJ, Wang JH. Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE(2) production in human patellar tendon fibroblasts. Gene 363: 166-172, 2005.
49. Yang JH, Sakamoto H, Xu EC, Lee RT. Biomechanical regulation of human monocyte/macrophage molecular function. Am J Pathol 156: 1797-1804, 2000.