Vasopressors are essential during cardiopulmonary resuscitation in rats: Is vasopressin superior to adrenaline?

Resuscitation

Volumn 72, Issue 1, 2007, Pages 137-144

  Popp, Erik ^a   Vogel, Peter ^a   Teschendorf, Peter ^a   Böttiger, Bernd W ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adrenaline; Apoptosis; Cardiac arrest; Cardiopulmonary resuscitation (CPR); Global cerebral ischaemia; Vasopressin; Vasopressor

Indexed keywords

ADRENALIN; HALOTHANE; NITRIC OXIDE; PLACEBO; VASOPRESSIN;

ANALYSIS OF VARIANCE; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; APOPTOSIS; ARTICLE; BEHAVIOR; BRAIN REGION; COMPARATIVE STUDY; CONTROLLED STUDY; DEFIBRILLATION; ELECTRICITY; HEART ARREST; HEART FIBRILLATION; HEART MUSCLE ISCHEMIA; HIPPOCAMPUS; HISTOLOGY; HISTOPATHOLOGY; KRUSKAL WALLIS TEST; LOG RANK TEST; MALE; MEAN ARTERIAL PRESSURE; NERVE CELL; NEUROLOGIC DISEASE; NEUROLOGY; NICK END LABELING; NISSL SUBSTANCE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REPERFUSION; RESUSCITATION; STATISTICAL ANALYSIS;

ANIMALS; BLOOD PRESSURE; BRAIN; CARDIOPULMONARY RESUSCITATION; DRUG THERAPY, COMBINATION; EPINEPHRINE; HEART ARREST; IN SITU NICK-END LABELING; MALE; RANDOM ALLOCATION; RATS; RATS, WISTAR; RETROGRADE DEGENERATION; VASOCONSTRICTOR AGENTS; VASOPRESSINS;

EID: 33845428388     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2006.05.015     Document Type: Article

References (30)

1. Böttiger B.W., Grabner C., Bauer H., et al. Long term outcome after out-of-hospital cardiac arrest with physician staffed emergency medical services: the Utstein style applied to a midsized urban/suburban area. Heart 82 (1999) 674-679
2. Choi D.W. Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 6 (1996) 667-672
3. Popp E., Padosch S.A., Vogel P., et al. Effects of intracerebroventricular application of brain-derived neurotrophic factor on cerebral recovery after cardiac arrest in rats. Crit Care Med 32 (2004) S359-S365
4. Brain Resuscitation Clinical Trial I Study Group. Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest. N Engl J Med 314 (1986) 397-403
5. Brain Resuscitation Clinical Trial II Study Group. A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest. N Engl J Med 324 (1991) 1225-1231
6. Nolan J.P., Deakin C.D., Soar J., Böttiger B.W., and Smith G. European Resuscitation Council guidelines for resuscitation 2005. Section 4. Adult advanced life support. Resuscitation 67 Suppl. 1 (2005) S39-S86
7. von Planta I., Weil M.H., von Planta M., et al. Cardiopulmonary resuscitation in the rat. J Appl Physiol 65 (1988) 2641-2647
8. Paradis N.A., Wenzel V., and Southall J. Pressor drugs in the treatment of cardiac arrest. Cardiol Clin 20 (2002) 61-78
9. Tang W., Weil M.H., Gazmuri R.J., et al. Pulmonary ventilation/perfusion defects induced by epinephrine during cardiopulmonary resuscitation. Circulation 84 (1991) 2101-2107
10. Berg R.A., Otto C.W., Kern K.B., et al. High-dose epinephrine results in greater early mortality after resuscitation from prolonged cardiac arrest in pigs: a prospective, randomized study. Crit Care Med 22 (1994) 282-290
11. Lindner K.H., Prengel A.W., Pfenninger E.G., et al. Vasopressin improves vital organ blood flow during closed-chest cardiopulmonary resuscitation in pigs. Circulation 91 (1995) 215-221
12. Wenzel V., Krismer A.C., Arntz H.R., et al. A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation. N Engl J Med 350 (2004) 105-113
13. Prengel A.W., Lindner K.H., Keller A., and Koehler R.C. Cerebral oxygenation during cardiopulmonary resuscitation with epinephrine and vasopressin in pigs. Stroke 27 (1996) 1241-1248
14. Wenzel V., Lindner K.H., Krismer A.C., et al. Repeated administration of vasopressin but not epinephrine maintains coronary perfusion pressure after early and late administration during prolonged cardiopulmonary resuscitation in pigs. Circulation 99 (1999) 1379-1384
15. Wenzel V., Lindner K.H., Prengel A.W., et al. Vasopressin improves vital organ blood flow after prolonged cardiac arrest with postcountershock pulseless electrical activity in pigs. Crit Care Med 27 (1999) 486-492
16. Voelckel W.G., Lurie K.G., McKnite S., et al. Comparison of epinephrine and vasopressin in a pediatric porcine model of asphyxial cardiac arrest. Crit Care Med 28 (2000) 3777-3783
17. Wenzel V., Linder K.H., Augenstein S., Prengel A.W., and Strohmenger H.U. Vasopressin combined with epinephrine decreases cerebral perfusion compared with vasopressin alone during cardiopulmonary resuscitation in pigs. Stroke 29 (1998) 1462-1467 discussion 67-8
18. European Communities Council. Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. http://europa.eu.int/smartapi/cgi/sga doc?smartapi!celexapi!prod!CELEXnumdoc&lg=EN&numdoc=31986L0609&model=guichett.
19. Katz L., Ebmeyer U., Safar P., Radovsky A., and Neumar R. Outcome model of asphyxial cardiac arrest in rats. J Cereb Blood Flow Metab 15 (1995) 1032-1039
20. Neumar R.W., Bircher N.G., Sim K.M., et al. Epinephrine and sodium bicarbonate during CPR following asphyxial cardiac arrest in rats. Resuscitation 29 (1995) 249-263
21. Gavrieli Y., Sherman Y., and Ben Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119 (1992) 493-501
22. Ferrer I., Tortosa A., Macaya A., et al. Evidence of nuclear DNA fragmentation following hypoxia-ischemia in the infant rat brain, and transient forebrain ischemia in the adult gerbil. Brain Pathol 4 (1994) 115-122
23. Ericsson B.F. Hemodynamic effects of vasopressin. An experimental study in normovolemic and hypovolemic anesthetized dogs. Acta Chir Scand Suppl 414 (1971) 1-29
24. Lebrun C., Rohmeiss P., Demmert G., Rettig R., and Unger T. Central cardiovascular actions of vasopressin in the rat. Can J Physiol Pharmacol 65 (1987) 1712-1716
25. Gedeborg R., Silander H.C., Ronne-Engstrom E., Rubertsson S., and Wiklund L. Adverse effects of high-dose epinephrine on cerebral blood flow during experimental cardiopulmonary resuscitation. Crit Care Med 28 (2000) 1423-1430
26. Ericsson B.F. Effect of vasopressin on the distribution of cardiac output and organ blood flow in the anesthetized dog. Acta Chir Scand 137 (1971) 729-738
27. Wenzel V., Lindner K.H., Krismer A.C., et al. Survival with full neurologic recovery and no cerebral pathology after prolonged cardiopulmonary resuscitation with vasopressin in pigs. J Am Coll Cardiol 35 (2000) 527-533
28. Lindner K.H., Prengel A.W., Brinkmann A., et al. Vasopressin administration in refractory cardiac arrest. Ann Intern Med 124 (1996) 1061-1064
29. Lindner K.H., Dirks B., Strohmenger H.U., et al. Randomised comparison of epinephrine and vasopressin in patients with out-of-hospital ventricular fibrillation. Lancet 349 (1997) 535-537
30. Stiell I.G., Hebert P.C., Wells G.A., et al. Vasopressin versus epinephrine for inhospital cardiac arrest: a randomised controlled trial. Lancet 358 (2001) 105-109