Degeneration of neuronal cell bodies following axonal injury in Wld S mice

Journal of Neuroscience Research

Volumn 84, Issue 8, 2006, Pages 1799-1807

  Wang, Ai Ling ^a   Yuan, Ming ^a   Neufeld, Arthur H ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Axon; Neurodegeneration; Optic nerve; Retinal ganglion cell; Wallerian degeneration

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AXONAL INJURY; BRAIN NERVE CELL; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENUCLEATION; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE DEGENERATION; NERVE FIBER TRANSPORT; NICK END LABELING; NONHUMAN; OPTIC NERVE; PHENOTYPE; PRIORITY JOURNAL; RETINA GANGLION CELL;

ANALYSIS OF VARIANCE; ANIMALS; CELL COUNT; DISEASE MODELS, ANIMAL; GLIAL FIBRILLARY ACIDIC PROTEIN; IN SITU NICK-END LABELING; MICE; MICE, INBRED C57BL; MICE, NEUROLOGIC MUTANTS; MICROSCOPY, ELECTRON, TRANSMISSION; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROFILAMENT PROTEINS; OPTIC NERVE INJURIES; RETINAL GANGLION CELLS; STILBAMIDINES; TIME FACTORS; WALLERIAN DEGENERATION;

EID: 33845423144     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21075     Document Type: Article

References (18)

1. s) nerves. BMC Neurosci 6:6.
2. Deckwerth TL, Johnson EM Jr. 1994. Neurites can remain viable after destruction of the neuronal soma by programmed cell death (apoptosis). Dev Biol 165:63-72.
3. Gillingwater TH, Haley JE, Ribchester RR, Horsburgh K. 2004. Neuroprotection after transient global cerebral ischemia in Wld(s) mutant mice. J Cereb Blood Flow Metab 24:62-66.
4. Glass JD, Brushart TM, George EB, Griffin JW. 1993. Prolonged survival of transected nerve fibres in C57BL/Ola mice is an intrinsic characteristic of the axon. J Neurocytol 22:311-321.
5. Kawai SI, Vora S, Das S, Gachie E, Becker B, Neufeld AH. 2001. Modeling of risk factors for the degeneration of retinal ganglion cells after ischemia/reperfusion in rats: effects of age, caloric restriction, diabetes, pigmentation, and glaucoma. FASEB J 15:1285-1287.
6. Kieran D, Hafezparast M, Bohnert S, Dick JR, Martin J, Schiavo G, Fisher EM, Greensmith L. 2005. A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice. J Cell Biol 169:561-567.
7. Ludwin SK, Bisby MA. 1992. Delayed wallerian degeneration in the central nervous system of Ola mice: an ultrastructural study. J Neurol Sci 109:140-147.
8. Lunn ER, Perry VH, Brown MC, Rosen H, Gordon S. 1989. Absence of Wallerian degeneration does not hinder regeneration in peripheral nerve. Eur J Neurosci 1:27-33.
9. Mack TG, Reiner M, Beirowski B, Mi W, Emanuelli M, Wagner D, Thomson D, Gillingwater T, Court F, Conforti L, Fernando FS, Tarlton A, Andressen C, Addicks K, Magni G, Ribchester RR, Perry VH, Coleman MP. 2001. Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat Neurosci 4:1199-1206.
10. Neufeld AH, Gachie EN. 2003. The inherent, age-dependent loss of retinal ganglion cells is related to the lifespan of the species. Neurobiol Aging 24:167-172.
11. Perry VH, Brown MC, Lunn ER, Tree P, Gordon S. 1990. Evidence that very slow Wallerian degeneration in C57BL/Ola mice is an intrinsic property of the peripheral nerve. Eur J Neurosci 2:802-808.
12. Perry VH, Brown MC, Lunn ER. 1991. Very slow retrograde and Wallerian degeneration in the CNS of C57BL/Ola mice. Eur J Neurosci 3:102-105.
13. Raff MC, Whitmore AV, Finn JT. 2002. Neuroscience-axonal self-destruction and neurodegeneration. Science 296:868-871.
14. Roy S, Zhang B, Lee VM, Trojanowski JQ. 2005. Axonal transport defects: a common theme in neurodegenerative diseases. Acta Neuropathol 109:5-13.
15. Sajadi A, Schneider BL, Aebischer P. 2004. Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease. Curr Biol 14:326-330.
16. s mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy. J Neurosci 23:2833-2839.
17. s does not attenuate mutant SOD1-mediated motor neuron disease. Neuromol Med 5:193-203.
18. Wang MS, Fang G, Culver DG, Davis AA, Rich MM, Glass JD. 2001. The Wld protein protects against axonal degeneration: a model of gene therapy for peripheral neuropathy. Ann Neurol 50:773-779.