The effect of nucleus pulposus crosslinking and glycosaminoglycan degradation on disc mechanical function

Biomechanics and Modeling in Mechanobiology

Volumn 6, Issue 1-2, 2007, Pages 13-20

  Yerramalli, C S ^a   Chou, A I ^b   Miller, G J ^b   Nicoll, S B ^b   Chin, K R ^a   Elliott, D M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOMECHANICS; COMPRESSIVE STRENGTH; CROSSLINKING; HISTOLOGY; MECHANICAL TESTING;

COMPRESSIVE MODULUS; GLYCOSAMINOGLYCAN DEGRADATION; GLYCOSAMINOGLYCANS (GAG); MECHANICAL LOADING; NUCLEUS PULPOSUS;

CELLS;

CHONDROITIN ABC LYASE; CROSS LINKING REAGENT; GENIPIN; GLYCOSAMINOGLYCAN; IRIDOID;

ANIMAL; ARTICLE; BIOMECHANICS; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; INTERVERTEBRAL DISK; LUMBAR VERTEBRA; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SPINE DISEASE; SPRAGUE DAWLEY RAT; WEIGHT BEARING;

ANIMALS; BIOMECHANICS; CHONDROITIN ABC LYASE; CROSS-LINKING REAGENTS; GLYCOSAMINOGLYCANS; INTERVERTEBRAL DISK; IRIDOIDS; LUMBAR VERTEBRAE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL DISEASES; WEIGHT-BEARING;

EID: 33845422997     PISSN: 16177959     EISSN: 16822978     Source Type: Journal    
DOI: 10.1007/s10237-006-0043-0     Document Type: Article

References (49)

1. Adams MA, McNally DS, Dolan P (1996) 'Stress' distributions inside intervertebral discs - The effects of age and degeneration. J Bone Joint Surg-Br 78B(6):965-972
2. Andersson GBJ, Schultz AB (1979) Effects of fluid injection on mechanical-properties of intervertebral disks. J Biomech 12(6):453-458
3. Ando T, Kato F, Mimatsu K, Iwata H (1995) Effects of chondroitinase Abe on degenerative intervertebral discs. Clin Orthop Relat Res (318):214-221
4. Boxberger JI, Sen S, Auerbach JA, Yerramalli CS, Elliott DM (2005) Glycosaminoglycan content affects intervertebral disc neutral zone mechanics in axial loading. Annual Meeting of Biomedical Engineering Society, Baltimore, Maryland. USA
5. Boxberger JI, Sen S, Yerramalli CS, Elliott DM (2006) Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in ratlumbar motin segments. J Orthop Res (in press)
6. Buckwalter JA (1995) Spine update - aging and degeneration of the human intervertebral disc. Spine 20(11):1307-1314
7. Buckwalter JA, Thomas A, Einhorn MD, Sheldon R Ed. (2000) Orthopaedic basic science, American Academy of Orthopaedic Surgeons
8. Difabio JL, Pearce RH, Caterson B, Hughes H (1987) The heterogeneity of the non-aggregating proteoglycans of the human intervertebral-disk. Biochem J 244(1):27-33
9. Duance VC, Crean JKG, Sims TJ, Avery N, Smith S, Menage J, Eisenstein SM, Roberts S (1998) Changes in collagen cross-linking in degenerative disc disease and scoliosis. Spine 23(23):2545-2551
10. Elliott DM, Sarver JJ (2004) Young investigator award winner: validation of the mouse and rat disc as mechanical models of the human lumbar disc. Spine 29(7):713-722
11. Eurell JAC, Brown MD, Ramos M (1990) The effects of chondroitinase abc on the rabbit intervertebral-disk - a roentgenographic and histologic-study. Clin Orthop Relat Res (256):238-243
12. Farndale RW. Sayers CA, Barrett AJ (1982) A direct spectrophotometric micro-assay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res 9(4):247-248
13. Fry TR, Eurell JC, Johnson AL, Brown MD, Losonsky JM, Schaeffer DJ (1991) Radiographic and histologic effects of chondroitinase abc on normal canine lumbar intervertebral-disk. Spine 16(7): 816-819
14. Hedman TP, Chuang S-Y, Syed B, Gray D (2003) Biomechanical benefits of crosslink augmentation in spinal discs. 2003 ASME International Mechanical Engineering Congress, Nov 15-212003, American Society of Mechanical Engineers, Washington, DC
15. Henderson N, Stanescu V, Cauchoix J (1991) Nucleolysis of the rabbit intervertebral-disk using chondroitinase abc. Spine 16(2):203-208
16. Herbage D, Bouillet J, Bernengo JC (1977) Biochemical and physicochemical characterization of pepsin-solubilized type-Ii collagen from bovine articular-cartilage. Biochem J 161(2):303-312
17. Hiyama K, Okada S (1975) Crystallization and some properties of chondroitinase from arthrobacter-aurescens. J Biol Chem 250(5): 1824-1828
18. Iatridis JC, Weidenbaum M, Setton LA, Mow VC (1996) Is the nucleus pulposus a solid or a fluid? mechanical behaviors of the nucleus pulposus of the human intervertebral disc. Spine 21(10):1174-1184
19. Johannessen W, Vresilovic EJ, Wright AC, Elliott DM (2004) Intervertebral disc mechanics are restored following cyclic loading and unloaded recovery. Ann Biomed Eng 32(1):70-76
20. Johannessen W, Vresilovic EJ, Mills JR, Cloyd JM, Guerin HL, Elliott DM (2005) Effect of nucleotomy on tension-compression behavior of the intervertebral disc. Transactions of Orthopaedic Research Society Meeting, Orthopaedic Research Society, Washington D.C.
21. Kato F, Iwata H, Mimatsu K, Miura T (1990) Experimental chemonucleolysis with chondroitinase-abc. Clin Orthop Relat Res (253): 301-308
22. Lu DS, Shono Y, Oda I, Abumi K, Kaneda K (1997) Effects of chondroitinase ABC and chymopapain on spinal motion segment biomechanics - An in vivo biomechanical, radiologic, and histologic canine study. Spine 22(16): 1828-1834
23. Luoma K. Riihimaki H, Luukkonen R, Raininko R, Viikari-Juntura E, Lamminen A (2000) Low back pain in relation to lumbar disc degeneration. Spine 25(4):487-492
24. Martinez JB, Oloyede VOA, Broom ND (1997) Biomechanics of load-bearing of the intervertebral disc: an experimental and finite element model. Med Eng Phys 19(2): 145-156
25. Mimura M, Panjabi MM, Oxlan TR, Crisco JJ, Yamamoto I, Vasavada A (1994) Disc degeneration affects the multidirectional flexibility of the lumbar spine. Spine 19(12):1371-1380
26. Monnier VM, Kohn RR, Cerami A (1984) Accelerated age-related browning of human collagen in diabetes-mellitus. In: Proceedings of the national academy of sciences of the United States of America-biological sciences 81(2):583-587
27. Nachemson A, Morris JM (1964) Invivo measurements of intradiscal pressure - discometry, a method for the determination of pressure in the lower lumbar discs. J Bone Joint Surg-Am 46(5): 1077-1092
28. Natarajan RN, Andersson GBJ (1999) The influence of lumbar disc height and cross-sectional area on the mechanical response of the disc to physiologic loading. Spine 24(18):1873-1881
29. Norcross JP, Lester GE, Weinhold P, Dahners LE (2003) An in vivo model of degenerative disc disease. J Orthop Res 21 (1): 183-188
30. Pal S, Tang LH, Choi H, Habermann E, Rosenberg L, Roughley P, Poole AR (1981) Structural-changes during development in bovine fetal epiphyseal cartilage. Coll Relat Res 1(2): 151-176
31. Panjabi MM (2003) Clinical spinal instability and low back pain. J Electromyogr Kinesiol 13(4):371-379
32. Pokharna HK, Phillips FM (1998) Collagen crosslinks in human lumbar intervertebral disc aging. Spine 23(15): 1645-1648
33. Riches PE, Dhillon N, Lotz J, Woods AW, McNally DS (2002) The internal mechanics of the intervertebral disc under cyclic loading. J Biomech 35(9): 1263-1271
34. Roughley PJ, Alini M, Antoniou J (2002) The role of proteoglycans in aging, degeneration and repair of the intervertebral disc. Biochem Soc Trans 30:869-874
35. Sarver JJ, Elliott DM (2004) Altered disc mechanics in mice genetically engineered for reduced type I collagen. Spine 29(10): 1094-1098
36. Sarver JJ, Elliott DM (2005) Mechanical differences between lumbar and tail discs in the mouse. J Orthop Res 23(1): 150-155
37. Sasaki M, Takahashi T. Miyahara K. Hirose T (2001) Effects of chondroitinase ABC on intradiscal pressure in sheep - An in vivo study. Spine 26(5):463-468
38. Saunders EC (1964) Treatment of canine intervertebral disc syndrome with chymopapain. J Am Vet Med Assoc 145(9):893-896
39. Schnider SL, Kohn RR (1981) Effects of age and diabetes-mellitus on the solubility and non-enzymatic glucosylation of human-skin collagen. J Clin Invest 67(6): 1630-1635
40. Smith L (1964) Enzyme dissolution of nucleus pulposus in humans. JAMA 187(2): 137-140
41. Smith L, Brown JE (1967) Treatment of lumbar intervertebral disc lesions by direct injection of chymopapain. J Bone Joint Surg Am 49B:502
42. Spencer DL, Miller JAA, Schultz AB (1985) The effects of chemonucleolysis on the mechanical-properties of the canine lumbar-disk. Spine 10(6):555-561
43. Stegeman H, Stalder K (1967) Determination of hydroxyproline. Clinica Chimica Acta 18(2):267-273
44. Sugimura T, Kato F, Mimatsu K, Takenaka O, Iwata H (1996) Experimental chemonucleolysis with chondroitinase ABC in monkeys. Spine 21(2):161-165
45. Sung HW, Chang Y, Chiu CT, Chen CN, Liang HC (1999a) Crosslinking characteristics and mechanical properties of a bovine pericardium fixed with a naturally occurring crosslinking agent. J Biomed Mat Res 47(2): 116-126
46. Sung HW, Huang DM, Chang WH, Huang RN, Hsu JC (1999b) Evaluation of gelatin hydrogel crosslinked with various crosslinking agents as bioadhesives: in vitro study. J Biomed Mat Res 46(4):520-530
47. Sung HW, Chang Y, Liang IL, Chang WH, Chen YC (2000) Fixation of biological tissues with a naturally occurring crosslinking agent: fixation rate and effects of pH, temperature, and initial fixative concentration. J Biomed Mat Res 52(1):77-87
48. Takahashi K, Inoue SI, Takada SI, Nishiyama H, Mimura M, Wada Y (1986) Experimental-study on chemonucleolysis with special reference to the change of intradiscal pressure. Spine 11(6):617-620
49. Thompson JP, Pearce RH, Schechter MT, Adams ME. Tsang IKY, Bishop PB (1990) Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral-disk. Spine 15(5): 411-415