The hepatoprotective effect of Vitamin C and E on hepatotoxicity induced by Ethanol in sprague dawley rats

Pakistan Journal of Nutrition

Volumn 5, Issue 6, 2006, Pages 507-511

  Oyinbo, C A ^a   Dare, W N ^a   Okogun, G R A ^a   Anyanwu, L C ^a   Ibeabuchi, N M ^b   Noronha, C C ^b   Okanlawon, O A ^b  

^a AMBROSE ALLI UNIVERSITY   (Nigeria)

^b UNIVERSITY OF LAGOS   (Nigeria)

Author keywords

Free radicals; Hepatoprotective; Vitamins C and E

Indexed keywords

ALCOHOL; ALPHA TOCOPHEROL; AMINOTRANSFERASE; ASCORBIC ACID; BILIRUBIN; FREE RADICAL; LIPID PEROXIDASE; MALONALDEHYDE; THIOBARBITURIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ALCOHOL LIVER DISEASE; AMINOTRANSFERASE BLOOD LEVEL; ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; HISTOPATHOLOGY; LIVER CELL; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; RAT; RAT STRAIN; TISSUE HOMOGENATE; VITAMIN SUPPLEMENTATION;

RATTUS;

EID: 33845416322     PISSN: 16805194     EISSN: None     Source Type: Journal    
DOI: 10.3923/pjn.2006.507.511     Document Type: Article

References (26)

1. Armitage, P. and G. Berry, 1985. In Statistical methods in medical research. 2nd Ed. London. Blackwell scientific publications, 201-3.
2. Befrits, R., M. Hedman and L. Blomquist, 1995. Chronic hepatitis C in alcoholic Patients; Prevalence, genotypes, and correlations of liver disease. Scand. J. Gastroenterol., 30: 1113-1118.
3. Berger, K., U.A. Ajani and C.A. Kase, 1999. Light-to-moderate alcohol consumption and risk of Stroke among US malephysicians. New Engl. J. Med., 341: 1557-1564.
4. Bland, J., 1986. The nutritional effect of free radical pathology: 1986/ A year in year in nutritional medicine, Keats Publishing Inc. New Cannon, CT, P: 16.
5. Dianzani, M.U., G. Muzio, M.E. Biocca and R.A. Canuto, 1991. Lipid peroxidation in fatty liver induced by caffeine in rat. Int. J. Tiss. Reac., 13: 79-85.
6. Diehi, A.M., Z. Goodmann and K.G. Ishak, 1988. Alcohol like liver disease in non-alcoholics; a clinical and histologic comparison with alcohol-induced Liver injury. Gastroenterology, 98: 1056-62.
7. Garfield, C.F., P.J. Chung and P.J. Rathouz, 2003. Alcohol advertising in magazines and adolescent readership. JAMA, 14 289(18): 2424-9.
8. Halliwell, B. and J. Gutteridge, 1984. Oxygen toxicity, oxygen-radicals Transition metals disease. J. Biochem., 219: 1-14.
9. Lecomte, F., B. Herberth, P. Pirrolet, Y. Chancerelle, J. Arnaud, N. Musse, F. Paille, G. Siest and Y. Artu,. 1994. Effect of alcohol consumption in blood Antioxidant nutrients and oxidative stree indicators. Am. J. Clin. Nutr., 60: 255-61.
10. Levine, S.A. and P.M. Kidd, 1985. Antioxidant Adaptation. Its role in free Radical pathology. San Leandro, C.A: Biocurrents, 171-218.
11. Li, D. and S.L. Friedman, 1999. Liver fibrogenesis and the role of hepatic stellate cell; new insights and prospects for therapy. J. Gast. Hep., 14: 618-33.
12. Lieber, C.S., 1993. Biochamical factors in alcoholic liver disease. Semin Liver Dis., 13: 136-53.
13. Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall, 1951. Protein measurement with folin phenol reagent. J. Bio. Chem., 193: 265-75.
14. Luna, L.G., 1966. Manual of histological staining. Methods of Armed Forces Institute of Pathology, London, 1-31.
15. Malloy, H.T., E.A. and Evelyn, 1937. The determination of bilirubin with the photoelectric colorimeter. J. Bio. Chem., 119: 481-5.
16. Normann, R., C. Ribiere and H. Rouach, 1992. Implication of free radical mechanism in ethanol induced cellular injury. Free Rad. Biol. Med., 12: 219-40.
17. Ohkawa, H. and N. Ohishi, 1979. Yashk Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem., 95: 351-8.
18. Olaso, E. and S.L. Friendman, 1998. Liver fibrogenesis and hepatic fibrogenesis. J Hepatol., 29: 837-47.
19. Retiman, S. and A.S. Frankel, 1957. A Colorimetric method for the determination of serum glutamic oxaloacetic and glutay pyruvic transaminases. Am. J. Clin. Pathol. 28: 53-6.
20. Stohs, S.J., 1995. The role of free radical in toxicity and disease. J. Basic Clin. Physiol. Pharmcol., 6: 205-28.
21. Traber, M.G., 1999. Utilization of vitamin E. Biofactors., 10: 115-20.
22. Treno, A.J., J.W. Grube and S.E. Martin, 2003. Alcohol availability as a predictor of youth drinking and driving: a hierarchical analysis of survey and archival data. Alcohol Clin. Exp. Res., 27: 835-40.
23. Underwood, J.C.E., 1992. Text book of General and systematic pathology. 1st edition, UK: Churchill Livingstone, 390-401.
24. Vivek, K., K.K. Pillai, S.Z. Hussiah and D.K. Balani, 1994 Hepatoprotective activity Of "Jigrine" on liver damage caused by alcohol-carbon tetrachloride and paracetamol in rats. Ind. J. Pharmacol., 26: 35-40.
25. Voehringer, D.W., D.L. Hirschberg, J. Xiao, Q. Lu, M. Roederer, C.B. Lock and L.A. Herzenberg. 2000. Gene microarray identification of redox and mitochondrial element that control resitance or sensitivity to apoptosis. Proc. Nat. Acad. Sci., 97: 2680-85.
26. Zdeneka, P., L.L. Cushman and B.C. Johnson, 1966. Estimation of product of lipid peroxidation (MDA) in biochemical systems. Anal. Biochem., 16: 359-64.