Light-to-moderate alcohol consumption and the risk of stroke among U.S. Male physicians

New England Journal of Medicine

Volumn 341, Issue 21, 1999, Pages 1557-1564

  Berger, Klaus ^a,f   Ajani, Umed A ^a   Kase, Carlos S ^e   Gaziano, J Michael ^a,b   Buring, Julie E ^a,c   Glynn, Robert J ^a,d   Hennekens, Charles H ^g  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Massachusetts Veterans Epidemiology Research and Information Center   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MÜNSTER   (Germany)

^g UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; CEREBROVASCULAR ACCIDENT; HUMAN; MALE; PHYSICIAN; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; STROKE; UNITED STATES;

ADULT; AGED; AGED, 80 AND OVER; ALCOHOL DRINKING; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; CEREBROVASCULAR ACCIDENT; ETHANOL; EXERCISE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; PHYSICIANS; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS; RISK FACTORS; UNITED STATES;

EID: 0032728509     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199911183412101     Document Type: Article

References (66)

1. Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 1997;349:1436-42.
2. Renaud S, Criqui MH, Farchi G, Veenstra J. Alcohol drinking and coronary heart disease. In: Verschuren PM, ed. Health issues related to alcohol consumption. Washington, D.C.: International Life Sciences Institute Press, 1993:81-123.
3. Camargo CA Jr. Moderate alcohol consumption and stroke: the epidemiologic evidence. Stroke 1989;20:1611-26.
4. Idem. Case-control and cohort studies of moderate alcohol consumption and stroke. Clin Chim Acta 1996;246:107-19.
5. Scherr PA, LaCroix AZ, Wallace RB, et al. Light to moderate alcohol consumption and mortality in the elderly. J Am Geriatr Soc 1992;40:651-7.
6. Sacco RL, Elkind M, Boden-Albala B, et al. The protective effect of moderate alcohol consumption on ischemic stroke. JAMA 1999;281:53-60.
7. Gill JS, Shipley MJ, Tsementzis SA, et al. Alcohol consumption - a risk factor for hemorrhagic and non-hemorrhagic stroke. Am J Med 1991;90: 489-97.
8. Kono S, Ikeda M, Tokudome S, Nishizumi M, Kuratsune M. Alcohol and mortality: a cohort study of male Japanese physicians. Int J Epidemiol 1986;15:527-32.
9. Stampfer MJ, Colditz GA, Willett WC, Speizer FE, Hennekens CH. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med 1988;319:267-73.
10. Donahue RP, Abbott RD, Reed DM, Yano K. Alcohol and hemorrhagic stroke: the Honolulu Heart Program. JAMA 1986;255:2311-4.
11. Gill JS, Shipley MJ, Hornby RH, Gill SK, Beevers DG. A community case-control study of alcohol consumption in stroke. Int J Epidemiol 1988; 17:542-7.
12. Gill JS, Zezulka AV, Shipley MJ, Gill SK, Beevers DG. Stroke and alcohol consumption. N Engl J Med 1986;315:1041-6.
13. Rodgers H, Aitken PD, French JM, Curless RH, Bates D, James OF. Alcohol and stroke: a case-control study of drinking habits past and present. Stroke 1993;24:1473-7.
14. Wolf PA, D'Agostino RB, Odell P, Belanger AJ, Hodges D, Kannel WB. Alcohol consumption as a risk factor for stroke: the Framingham study. Ann Neurol 1988;24:177. abstract.
15. Palomäki H, Kaste M. Regular light-to-moderate intake of alcohol and the risk of ischemic stroke: is there a beneficial effect? Stroke 1993;24: 1828-32.
16. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly U.S. adults. N Engl J Med 1997;337: 1705-14.
17. Kiyohara Y, Kato I, Iwamoto H, Nakayama K, Fujishima M. The impact of alcohol and hypertension on stroke incidence in a general Japanese population: The Hisayama Study. Stroke 1995;26:368-72.
18. Palmer AJ, Fletcher AE, Bulpitt CJ, et al. Alcohol intake and cardiovascular mortality in hypertensive patients: report from the Department of Health Hypertension Care Computing Project. J Hypertens 1995;13:957-64.
19. Shaper AG, Wannamethee G, Walker M. Alcohol and mortality in British men: explaining the U-shaped curve. Lancet 1988;2:1267-73.
20. Shaper AG. Alcohol and mortality: a review of prospective studies. Br J Addict 1990;85:837-47.
21. Wannamethee SG, Shaper AG. Patterns of alcohol intake and risk of stroke in middle-aged British men. Stroke 1996;27:1033-9.
22. Marmot M, Brunner E. Alcohol and cardiovascular disease: the status of the U shaped curve. BMJ 1991;303:565-8.
23. Criqui MH. The reduction of coronary heart disease with light to moderate alcohol consumption: effect or artifact? Br J Addict 1990;85: 854-7.
24. Boffetta P, Garfinkel L. Alcohol drinking and mortality among men enrolled in an American Cancer Society prospective study. Epidemiology 1990;1:342-8.
25. Steering Committee of the Physicians' Health Study Research Group. Final report on the aspirin component of the ongoing Physicians' Health Study. N Engl J Med 1989;321:129-35.
26. Manson JE, Buring JE, Satterfield S, Hennekens CH. Baseline characteristics of participants in the Physicians' Health Study: a randomized trial of aspirin and beta-carotene in U.S. physicians. Am J Prev Med 1991;7:150-4.
27. Camargo CA Jr, Hennekens CH, Gaziano JM, Glynn RJ, Manson JE, Stampfer MJ. Prospective study of moderate alcohol consumption and mortality in US male physicians. Arch Intern Med 1997;157:79-85.
28. Klag MJ, He J, Mead LA, Ford DE, Pearson TA, Levine DM. Validity of physicians' self-reports of cardiovascular disease risk factors. Ann Epidemiol 1993;3:442-7.
29. Berger K, Kase CS, Buring JE. Interobserver agreement in the classification of stroke in the Physicians' Health Study. Stroke 1996;27:238-42.
30. Cox DR. Regression models and life-tables. J R Stat Soc [B] 1972;34: 187-220.
31. Hennekens CH, Buring JE. Epidemiology in medicine. Boston: Little, Brown, 1987.
32. Williams GD, Aitken SS, Malin H. Reliability of self-reported alcohol consumption in a general population survey. J Stud Alcohol 1985;46:223-7.
33. Giovannucci E, Colditz G, Stampfer MJ, et al. The assessment of alcohol consumption by a simple self-administered questionnaire. Am J Epidemiol 1991;133:810-7.
34. Ascherio A, Rimm EB, Giovannucci EL, et al. A prospective study of nutritional factors and hypertension among US men. Circulation 1992;86: 1475-84.
35. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992;339:1523-6.
36. Ruf JC, Berger JL, Renaud S. Platelet rebound effect of alcohol withdrawal and wine drinking in rats: relation to tannins and lipid peroxidation. Arterioscler Thromb Vasc Biol 1995;15:140-4.
37. Hillbom M, Kaste M. Alcohol intoxication: a risk factor for primary subarachnoid hemorrhage. Neurology 1982;32:706-11.
38. Juvela S, Hillbom M, Numminen H, Koskinen P. Cigarette smoking and alcohol consumption as risk factors for aneurysmal subarachnoid hemorrhage. Stroke 1993;24:639-46.
39. Juvela S, Hillbom M, Palomäki H. Risk factors for spontaneous intracerebral hemorrhage. Stroke 1995;26:1558-64.
40. Kauhanen J, Kaplan GA, Goldberg DE, Salonen JT. Beer binging and mortality: results from the Kuopio ischaemic heart disease risk factor study, a prospective population based study. BMJ 1997;315:846-51.
41. Kiechl S, Willeit J, Egger G, Oberhollenzer M, Aichner F. Alcohol consumption and carotid atherosclerosis: evidence of dose-dependent atherogenic and antiatherogenic effects: results from the Bruneck Study. Stroke 1994;25:1593-8.
42. Kiechl S, Willeit J, Rungger G, Egger G, Oberhollenzer F, Bonora E. Alcohol consumption and atherosclerosis: what is the relation? Prospective results from the Bruneck Study. Stroke 1998;29:900-7.
43. Reed DM, Resch JA, Hayashi T, MacLean CJ, Yano K. A prospective study of cerebral artery atherosclerosis. Stroke 1988;19:820-5.
44. Watts GF, Mazurkiewicz JC, Tonge K, Nelson V, Warburton FG, Slavin BM. Lipoprotein(a) as a determinant of the severity of angiographically defined carotid atherosclerosis. QJM 1995;88:321-6.
45. Gordon T, Kannel WB, Castelli WP, Dawber TR. Lipoproteins, cardiovascular disease, and death: the Framingham Study. Arch Intern Med 1981;141:1128-31.
46. Langer RD, Criqui MH, Reed DM. Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease. Circulation 1992;85:910-5.
47. Rath M, Niendorf A, Reblin T, Dietel M, Krebber HJ, Beisiegel U. Detection and quantification of lipoprotein(a) in the arterial wall of 107 coronary bypass patients. Arteriosclerosis 1989;9:579-92. [Erratum, Arteriosclerosis 1990;10:1147]
48. Jurgens G, Koltringer P. Lipoprotein(a) in ischemic cerebrovascular disease: a new approach to the assessment of risk for stroke. Neurology 1987;37:513-5.
49. Nago N, Kayaba K, Hiraoka J, et al. Lipoprotein(a) levels in the Japanese population: influence of age and sex, and relation to atherosclerotic risk factors: the Jichi Medical School Cohort Study. Am J Epidemiol 1995; 141:815-21.
50. Quyyumi AA. Endothelial function in health and diseass: new insights into the genesis of cardiovascular disease. Am J Med 1998;105:32S-39S.
51. Fields CE, Makhoul RG. Vasomotor tone and the role of nitric oxide. Semin Vasc Surg 1998;11:181-92.
52. Durante W, Cheng K, Sunahara RK, Schafer AI. Ethanol potentiates interleukin-1 beta-stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells. Biochem J 1995;308:231-6.
53. Criqui MH, Cowan LD, Tyroler HA, et al. Lipoproteins as mediators for the effects of alcohol consumption and cigarette smoking on cardiovascular mortality: results from the Lipid Research Clinics Follow-up Study. Am J Epidemiol 1987;126:629-37.
54. Flegal KM, Cauley JA. Alcohol consumption and cardiovascular risk factors. Recent Dev Alcohol 1985;3:165-80.
55. Kasturi R, Yatsu FM, Alam R, Rogers S. Restriction fragment length polymorphism of the apoprotein A-I-C-III gene cluster in control and stroke-prone white and black subjects: racial differences. Stroke 1992;23:1257-64.
56. Bihari-Varga M, Szekely J, Gruber E. Plasma high density lipoproteins in coronary, cerebral and peripheral vascular disease: the influence of various risk factors. Atherosclerosis 1981;40:337-45.
57. Adams RJ, Carroll RM, Nichols FT, et al. Plasma lipoproteins in cortical versus lacunar infarction. Stroke 1989;20:448-52.
58. Glueck CJ, Rorick MH, Schmerler M, et al. Hypofibrinolytic and atherogenic risk factors for stroke. J Lab Clin Med 1995;125:319-25.
59. Torres Duarte AP, Dong QS, Young J, Abi-Younes S, Myers AK. Inhibition of platelet aggregation in whole blood by alcohol. Thromb Res 1995;78:107-15.
60. Landolfi R, Steiner M. Ethanol raises prostacyclin in vivo and in vitro. Blood 1984;64:679-82.
61. Altura BM, Altura BT. Role of magnesium and calcium in alcohol-induced hypertension and strokes as probed by in vivo television microscopy, digital image microscopy, optical spectroscopy, 31P-NMR, spectroscopy and a unique magnesium ion-selective electrode. Alcohol Clin Exp Res 1994;18:1057-68.
62. Ridker PM, Vaughan DE, Stampfer MJ, Sacks FM, Hennekens CH. A cross-sectional study of endogenous tissue plasminogen activator, total cholesterol, HDL cholesterol, and apolipoproteins A-I, A-II, and B-100. Arterioscler Thromb 1993;13:1587-92.
63. Ridker PM, Vaughan DE, Stampfer MJ, Glynn RJ, Hennekens CH. Association of moderate alcohol consumption and plasma concentration of endogenous tissue-type plasminogen activator. JAMA 1994;272:929-33.
64. Ernst E, Resch KL. Fibrinogen as a cardiovascular risk factor: a metaanalysis and review of the literature. Ann Intern Med 1993;118:956-63.
65. Ridker PM, Hennekens CH, Stampfer MJ, Manson JE, Vaughan DE. Prospective study of endogenous tissue plasminogen activator and risk of stroke. Lancet 1994;343:940-3.
66. Rose G, Day S. The population mean predicts the number of deviant individuals. BMJ 1990;301:1031-4.