Is functional dyspepsia of particular concern in women? A review of gender differences in epidemiology, pathophysiologic mechanisms, clinical presentation, and management

American Journal of Gastroenterology

Volumn 101, Issue SUPPL. 3, 2006, Pages s644-s653

  Flier, Sarah N ^a   Rose, Suzanne ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALOSETRON; CISAPRIDE; FLUOXETINE; HISTAMINE H2 RECEPTOR ANTAGONIST; PROTON PUMP INHIBITOR; SEROTONIN UPTAKE INHIBITOR; TEGASEROD; TRICYCLIC ANTIDEPRESSANT AGENT;

BACTERIAL INFECTION; BARRETT ESOPHAGUS; CLINICAL FEATURE; CLINICAL TRIAL; CONFERENCE PAPER; CONSTIPATION; DEPRESSION; DIARRHEA; DIET THERAPY; DRUG WITHDRAWAL; DYSPEPSIA; ENTERITIS; ESOPHAGITIS; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL DISEASE; HELICOBACTER PYLORI; HUMAN; MENSTRUATION; META ANALYSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; PSYCHOTHERAPY; QT PROLONGATION; SEX DIFFERENCE; SEXUALITY; STOMACH EMPTYING; STOMACH MOTILITY; SYSTEMATIC REVIEW; TORSADE DES POINTES; TREATMENT RESPONSE; WELLBEING; WOMEN'S HEALTH;

EID: 33845414928     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2006.01015.x     Document Type: Conference Paper

References (91)

1. Talley NJ. American Gastroenterological Association medical position statement: Evaluation of dyspepsia. Gastroenterology 2005;129:1753-5.
2. Talley NJ, Vakil NB, Moayyedi P. American gastroenterological association technical review on the evaluation of dyspepsia. Gastroenterology 2005;129:1756-80.
3. Talley NJ, Colin-Jones D, Koch KL, et al. Functional dyspepsia: A classification with guidelines for diagnosis and management. Gastroenterol Int 1991;4:145-60.
4. Talley NJ, Vakil N. Guidelines for the management of dyspepsia. Am J Gastroenterol 2005;100:2324-37.
5. Tack J, Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. Gastroenterology 2006;130:1466-79.
6. Heading RC. Prevalence of upper gastrointestinal symptoms in the general population: A systematic review. Scand J Gastroenterol Suppl 1999;231:3-8.
7. Talley NJ. Dyspepsia: Management guidelines for the millennium. Gut 2002;50(suppl 4):iv72-8; discussion iv9.
8. Majumdar SR, Soumerai SB, Farraye FA, et al. Chronic acid-related disorders are common and underinvestigated. Am J Gastroenterol 2003;98:2409-14.
9. Locke GR 3rd. Prevalence, incidence and natural history of dyspepsia and functional dyspepsia. Baillieres Clin Gastroenterol 1998;12:435-42.
10. Frank L, Kleinman L, Ganoczy D, et al. Upper gastrointestinal symptoms in North America: Prevalence and relationship to healthcare utilization and quality of life. Dig Dis Sci 2000;45:809-18.
11. Stanghellini V. Three-month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: Results from the Domestic/ International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol Suppl 1999;231:20-8.
12. Shaib Y, El-Serag HB. The prevalence and risk factors of functional dyspepsia in a multiethnic population in the United States. Am J Gastroenterol 2004;99:2210-6.
13. Heading RC. Definitions of dyspepsia. Scand J Gastroenterol Suppl 1991;182:1-6.
14. Westbrook JI, Talley NJ, Westbrook MT. Gender differences in the symptoms and physical and mental well-being of dyspeptics: A population based study. Qual Life Res 2002;11:283-91.
15. Heikkinen M, Pikkarainen P, Takala J, et al. Etiology of dyspepsia: Four hundred unselected consecutive patients in general practice. Scand J Gastroenterol 1995;30:519-23.
16. Mansi C, Mela GS, Pasini D, et al. Patterns of dyspepsia in patients with no clinical evidence of organic diseases. Dig Dis Sci 1990;35:1452-8.
17. Toner BB, Akman D. Gender role and irritable bowel syndrome: Literature review and hypothesis. Am J Gastroenterol 2000;95:11-6.
18. Drossman DA, Li Z, Andruzzi E, et al. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci 1993;38:1569-80.
19. Bernersen B, Johnsen R, Straume B. Non-ulcer dyspepsia and peptic ulcer: The distribution in a population and their relation to risk factors. Gut 1996;38:822-5.
20. Ronkainen J, Aro P, Storskrubb T, et al. High prevalence of gastroesophageal reflux symptoms and esophagitis with or without symptoms in the general adult Swedish population: A Kalixanda study report. Scand J Gastroenterol 2005;40:275-85.
21. Aro P, Ronkainen J, Storskrubb T, et al. Findings at upper endoscopy in a random adult population. Gastroenterology 2002;122(suppl 1):A568.
22. Aro P, Ronkainen J, Storskrubb T, et al. Valid symptom reporting at upper endoscopy in a random sample of the Swedish adult general population: The Kalixanda study. Scand J Gastroenterol 2004;39:1280-8.
23. Aro P, Ronkainen J, Talley NJ, et al. Body mass index and chronic unexplained gastrointestinal symptoms: An adult endoscopic population based study. Gut 2005;54:1377-83.
24. Delgado-Aros S, Camilleri M, Cremonini F, et al. Contributions of gastric volumes and gastric emptying to meal size and postmeal symptoms in functional dyspepsia. Gastroenterology 2004;127:1685-94.
25. Timmons S, Liston R, Moriarty KJ. Functional dyspepsia: Motor abnormalities, sensory dysfunction, and therapeutic options. Am J Gastroenterol 2004;99:739-49.
26. Tack J, Bisschops R, Sarnelli G. Pathophysiology and treatment of functional dyspepsia. Gastroenterology 2004;127:1239-55.
27. Mayer EA, Naliboff BD, Chang L, et al. Stress and the gastrointestinal tract. V. Stress and irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 2001;280:G519-24.
28. Arendt-Nielsen L, Bajaj P, Drewes AM. Visceral pain: Gender differences in response to experimental and clinical pain. Eur J Pain 2004;8:465-72.
29. Mayer EA, Naliboff B, Lee O, et al. Review article: Gender-related differences in functional gastrointestinal disorders. Aliment Pharmacol Ther 1999;13(suppl 2):65-9.
30. Sloots CE, Felt-Bersma RJ, Cuesta MA, et al. Rectal visceral sensitivity in healthy volunteers: Influences of gender, age and methods. Neurogastroenterol Motil 2000;12:361-8.
31. Mayer EA, Berman S, Chang L, et al. Sex-based differences in gastrointestinal pain. Eur J Pain 2004;8:451-63.
32. Nguyen P, Lee SD, Castell DO. Evidence of gender differences in esophageal pain threshold. Am J Gastroenterol 1995;90:901-5.
33. Tack J, Piessevaux H, Coulie B, et al. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998;115:1346-52.
34. Mertz H, Fullerton S, Naliboff B, et al. Symptoms and visceral perception in severe functional and organic dyspepsia. Gut 1998;42:814-22.
35. Tack J, Caenepeel P, Fischler B, et al. Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterology 2001;121:526-35.
36. Holtmann G, Goebell H, Talley NJ. Functional dyspepsia and irritable bowel syndrome: Is there a common pathophysiological basis? Am J Gastroenterol 1997;92:954-9.
37. Strid H, Norstrom M, Sjoberg J, et al. Impact of sex and psychological factors on the water loading test in functional dyspepsia. Scand J Gastroenterol 2001;36:725-30.
38. Heitkemper MM, Jarrett M. Pattern of gastrointestinal and somatic symptoms across the menstrual cycle. Gastroenterology 1992;102:505-13.
39. Datz FL, Christian PE, Moore J. Gender-related differences in gastric emptying. J Nucl Med 1987;28:1204-7.
40. Hutson WR, Roehrkasse RL, Wald A. Influence of gender and menopause on gastric emptying and motility. Gastroenterology 1989;96:11-7.
41. Sarnelli G, Caenepeel P, Geypens B, et al. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol 2003;98:783-8.
42. Talley NJ, Verlinden M, Jones M. Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia? Am J Gastroenterol 2001;96:1422-8.
43. Stanghellini V, Tosetti C, Paternico A, et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 1996;110:1036-42.
44. Lorena SL, Tinois E, Brunetto SQ, et al. Gastric emptying and intragastric distribution of a solid meal in functional dyspepsia: Influence of gender and anxiety. J Clin Gastroenterol 2004;38:230-6.
45. Stanghellini V, Corinaldesi R, Tosetti C. Relevance of gastrointestinal motor disturbances in functional dyspepsia. Baillieres Clin Gastroenterol 1998;12:533-44.
46. Kellow JE, Delvaux M, Azpiroz F, et al. Principles of applied neurogastroenterology: Physiology/motility-sensation. Gut 1999;45(suppl 2):II17-24.
47. Quartero AO, de Wit NJ, Lodder AC, et al. Disturbed solid-phase gastric emptying in functional dyspepsia: A meta-analysis. Dig Dis Sci 1998;43:2028-33.
48. Mones J, Carrio I, Calabuig R, et al. Influence of the menstrual cycle and of menopause on the gastric emptying rate of solids in female volunteers. Eur J Nucl Med 1993;20:600-2.
49. Caballero-Plasencia AM, Valenzuela-Barranco M, Martin-Ruiz JL, et al. Are there changes in gastric emptying during the menstrual cycle? Scand J Gastroenterol 1999;34:772-6.
50. Gill RC, Murphy PD, Hooper HR, et al. Effect of the menstrual cycle on gastric emptying. Digestion 1987;36:168-74.
51. Parkman HP, Harris AD, Miller MA, et al. Influence of age, gender, and menstrual cycle on the normal electrogastrogram. Am J Gastroenterol 1996;91:127-33.
52. Mearadji B, Penning C, Vu MK, et al. Influence of gender on proximal gastric motor and sensory function. Am J Gastroenterol 2001;96:2066-73.
53. Su YC, Wang WM, Wang SY, et al. The association between Helicobacter pylori infection and functional dyspepsia in patients with irritable bowel syndrome. Am J Gastroenterol 2000;95:1900-5.
54. Moayyedi P, Deeks J, Talley NJ, et al. An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: Resolving the discrepancy between systematic reviews. Am J Gastroenterol 2003;98:2621-6.
55. Tack J, Demedts I, Dehondt G, et al. Clinical and pathophysiological characteristics of acute-onset functional dyspepsia. Gastroenterology 2002;122:1738-47.
56. O'Sullivan M, Clayton N, Breslin NP, et al. Increased mast cells in the irritable bowel syndrome. Neurogastroenterol Motil 2000;12:449-57.
57. Feinle-Bisset C, Vozzo R, Horowitz M, et al. Diet, food intake, and disturbed physiology in the pathogenesis of symptoms in functional dyspepsia. Am J Gastroenterol 2004;99:170-81.
58. Agreus L. Natural history of dyspepsia. Gut 2002;50(suppl 4):iv2-9.
59. Agreus L, Svardsudd K, Nyren O, et al. Irritable bowel syndrome and dyspepsia in the general population: Overlap and lack of stability over time. Gastroenterology 1995;109:671-80.
60. Colin-Jones DG. The management of dyspepsia. Scand J Gastroenterol Suppl 1988;155:96-100.
61. Drossman DA, Thompson WG, Talley NJ. Identification of subgroups of functional gastrointestinal disorders. Gastroenterol Int 1990;3:159-72.
62. Talley NJ, Stanghellini V, Heading RC, et al. Functional gastroduodenal disorders. Gut 1999;45(suppl 2):II37-42.
63. Holtmann G, Stanghellini V, Talley NJ. Nomenclature of dyspepsia, dyspepsia subgroups and functional dyspepsia: Clarifying the concepts. Baillieres Clin Gastroenterol 1998;12:417-33.
64. Talley NJ, Zinsmeister AR, Schleck CD, et al. Dyspepsia and dyspepsia subgroups: A population-based study. Gastroenterology 1992;102:1259-68.
65. Talley NJ, Weaver AL, Tesmer DL, et al. Lack of discriminant value of dyspepsia subgroups in patients referred for upper endoscopy. Gastroenterology 1993;105:1378-86.
66. Stanghellini V, Tosetti C, Paternico A, et al. Predominant symptoms identify different subgroups in functional dyspepsia. Am J Gastroenterol 1999;94:2080-5.
67. Ahlawat SK, Richard Locke G, Weaver AL, et al. Dyspepsia consulters and patterns of management: A population-based study. Aliment Pharmacol Ther 2005;22:251-9.
68. Drossman DA, Creed FH, Olden KW, et al. Psychosocial aspects of the functional gastrointestinal disorders. Gut 1999;45(suppl 2):II25-30.
69. Drossman DA, McKee DC, Sandler RS, et al. Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome. Gastroenterology 1988;95:701-8.
70. Talley NJ, Boyce P, Jones M. Dyspepsia and health care seeking in a community: How important are psychological factors? Dig Dis Sci 1998;43:1016-22.
71. Furne JK, Levitt MD. Factors influencing frequency of flatus emission by healthy subjects. Dig Dis Sci 1996;41:1631-5.
72. Chang L, Toner BB, Fukudo S, et al. Gender, age, society, culture, and the patient's perspective in the functional gastrointestinal disorders. Gastroenterology 2006;130:1435-46.
73. Lydiard RB. Increased prevalence of functional gastrointestinal disorders in panic disorder: Clinical and theoretical implications. CNS Spectr 2005;10:899-908.
74. Koloski NA, Talley NJ, Boyce PM. A history of abuse in community subjects with irritable bowel syndrome and functional dyspepsia: The role of other psychosocial variables. Digestion 2005;72:86-96.
75. Drossman DA, Leserman J, Nachman G, et al. Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Ann Intern Med 1990;113:828-33.
76. Talley NJ, Fett SL, Zinsmeister AR, et al. Gastrointestinal tract symptoms and self-reported abuse: A population-based study. Gastroenterology 1994;107:1040-9.
77. Perona M, Benasayag R, Perello A, et al. Prevalence of functional gastrointestinal disorders in women who report domestic violence to the police. Clin Gastroenterol Hepatol 2005;3:436-41.
78. Fass R, Fullerton S, Naliboff B, et al. Sexual dysfunction in patients with irritable bowel syndrome and non-ulcer dyspepsia. Digestion 1998;59:79-85.
79. Varmus H. NIH guidelines on the inclusion of women and minorities as subjects in clinical research. Fed Regist 1994;59:14508-13.
80. Miller MA. Gender-based differences in the toxicity of pharmaceuticals - the Food and Drug Administration's perspective. Int J Toxicol 2001;20:149-52.
81. Lin M, Gerson LB, Lascar R, et al. Features of gastroesophageal reflux disease in women. Am J Gastroenterol 2004;99:1442-7.
82. http://www.clinicaltrials.gov/ct/gui/show/NCT00171457.
83. Gulten T, Tokyay N, Demiray M, et al. The role of triple therapy, age, gender and smoking on the genotoxic effects of Helicobacter pylori infection. J Int Med Res 2002;30:380-5.
84. Jackson JL, O'Malley PG, Tomkins G, et al. Treatment of functional gastrointestinal disorders with antidepressant medications: A meta-analysis. Am J Med 2000;108:65-72.
85. Kornstein SG, Schatzberg AF, Thase ME, et al. Gender differences in treatment response to sertraline versus imipramine in chronic depression. Am J Psychiatry 2000;157:1445-52.
86. Thase ME, Entsuah R, Cantillon M, et al. Relative antidepressant efficacy of venlafaxine and SSRIs: Sex-age interactions. J Womens Health (Larchmt) 2005;14:609-16.
87. Lewis-Hall FC, Wilson MG, Tepner RG, et al. Fluoxetine vs. tricyclic antidepressants inwomen with major depressive disorder. J Womens Health 1997;6:337-43.
88. Parker G, Parker K, Austin MP, et al. Gender differences in response to differing antidepressant drug classes: Two negative studies. Psychol Med 2003;33:1473-7.
89. Fisher RS, Parkman HP. Management of nonulcer dyspepsia. N Engl J Med 1998;339:1376-81.
90. Ahlawat SK, Cuddihy MT, Locke GR 3rd. Gender-related differences in dyspepsia: A qualitative systematic review. Gend Med 2006;3:31-42.
91. Colameco S, Becker LA, Simpson M. Sex bias in the assessment of patient complaints. J Fam Pract 1983;16:1117-21.