Functional dyspepsia and irritable bowel syndrome: Is there a common pathophysiological basis?

American Journal of Gastroenterology

Volumn 92, Issue 6, 1997, Pages 954-959

  Holtmann, Gerald ^a   Goebell, Harald ^b   Talley, Nicholas J ^b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; DYSPEPSIA; FEMALE; HUMAN; INTESTINE MOTILITY; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; MANOMETRY; MECHANORECEPTOR; PAIN THRESHOLD; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ADULT; AGE FACTORS; CASE-CONTROL STUDIES; COLONIC DISEASES, FUNCTIONAL; DIGESTION; DUODENUM; DYSPEPSIA; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL MOTILITY; HUMANS; INTESTINE, SMALL; MALE; MECHANORECEPTORS; PEPTIC ULCER; PERISTALSIS; PRESSURE; REPRODUCIBILITY OF RESULTS; SENSORY THRESHOLDS; SEX FACTORS;

EID: 0030976434     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Talley NJ, Colin-Jones D, Koch KL, et al. Functional dyspepsia: A classification with guidelines for diagnosis and management. Gastroenterol Int 1991;4:145-60.
2. Drossman DA, Thompson WG, Talley NJ, et al. Identification of sub-groups of functional gastrointestinal disorders. Gastroenterol Int 1990;3:159-72.
3. George AA, Tsuchiyose M, Dooley CP. Sensitivity of the gastric mucosa to acid and duodenal contents in patients with nonulcer dyspepsia. Gastroenterology 1991;101:3-6.
4. Lemann M, Dederding JP, Flourie B, et al. Abnormal perception of visceral pain in response to gastric distension in chronic idiopathic dyspepsia: The irritable stomach syndrome. Dig Dis Sci 1991;36: 1249-54.
5. Bradette M, Pare P, Douville P, et al. Visceral perception in health and functional dyspepsia: Crossover study of gastric distension with placebo and domperidone. Dig Dis Sci 1991;36:52-8.
6. Mearin F, Cucala M, Azpiroz F, et al. The origin of symptoms on the brain-gut axis in functional dyspepsia. Gastroenterology 1991;101: 999-1006.
7. Coffin B, Azpiroz F, Guarner F, et al. Selective gastric hypersensitivity and reflex hyporeactivity in functional dyspepsia. Gastroenterology 1994;107:1345-51.
8. Greydanus MP, Vassallo M, Camilleri M, et al. Neurohormonal factors in functional dyspepsia: Insights on pathophysiological mechanisms. Gastroenterology 1991;100:1311-8.
9. Ritchie J. Pain from distension of the pelvic colon by inflating a ballon in the irritable bowel syndrom. Gut 1973;14:125-32.
10. Whitehead WE, Holtkotter B, Enck P, et al. Tolerance of rectosigmoid distension in irritable bowel syndrome. Gastroenterology 1990;90: 1187-92.
11. Accarino AM, Azpiroz F, Malagelada JR. Selective dysfunction of mechanosensitive intestinal afferents in irritable bowel syndrome. Gastroenterology 1995;108:636-43.
12. Talley NJ, Phillips SF, Bruce B, et al. Multisystem complaints in patients with the irritable bowel syndrome and functional dyspepsia. Eur J Gastroenterol Hepatol 1991;3:71-7.
13. Drossman DA, Li Z, Andruzzi E, et al. Householder survey of functional gastrointestinal disorders: Prevalence, sociodemography, and health impact. Dig Dis Sci 1993;38:1569-80.
14. Agreus L, Svärdsudd K, Nyren O, et al. Irritable bowel syndrome and dyspepsia in the general population: Overlap and lack of stability over time. Gastroenterology 1995;109:671-80.
15. Talley NJ. Spectrum of chronic dyspepsia in the presence of the irritable bowel syndrome. Scand J Gastroenterol [Suppl] 1991;182:7-10.
16. Holtmann G, Goebell H, Holtmann M, et al. Dyspepsia in healthy blood donors: Pattern of symptoms and association with Helicobacter pylori. Dig Dis Sci 1994;39:1090-8.
17. Holtmann G, Goebell H, Talley NJ. Dyspepsia in consulters and non-consulters: Prevalence, health-care seeking behaviour and risk factors. Eur J Gastroenterol Hepatol 1994;6:917-24.
18. Talley NJ, Zinsmeister AR, Schleck CD, et al. Dyspepsia and dyspepsia subgroups: A population-based study. Gastroenterology 1992;102: 1259-68.
19. Camilleri M, Malagelada JR, Kao PC, et al. Gastric and autonomie responses to stress in functional dyspepsia. Dig Dis Sci 1986;31:1169-77.
20. Talley NJ, Phillips SF, Melton LJI, et al. A patient questionnaire to identify bowel disease. Ann Intern Med 1989;111:671-4.
21. Holtmann G, Neufang-Hüber J, Talley NJ, Goebell H, and Members of the dyspepsia study group: Patterns of symptoms in functional dyspepsia: Predictors of a response to treatment. Gastroenterology 1996; 110:A680.
22. Thompson WG, Heaton KW. Functional bowel disorders in apparently healthy people. Gastroenterology 1980;79:283-8.
23. Colin-Jones DG, Bloom B, Bodemar G, et al. Management of dyspepsia: Report of a working party. Lancet 1988;1:576-9.
24. Thompson WG, Dotevall G, Drossman DA, et al. Irritable bowel syndrome: Guidelines for the diagnosis. Gastroenterol Int 1989;2: 92-5.
25. Holtmann G, Gschossmann J, Guerra G, et al. Perception of gastric distension: Influence of mode of distension on perception thresholds and gastric compliance. Dig Dis Sci 1995;40:2673-7.
26. Holtmann G, Goebell H, Talley NJ. Impaired small intestinal peristaltic reflexes and sensory thresholds are independent functional disturbances in patients with chronic unexplained dyspepsia. Am J Gastroenterol 1996;91:485-91.
27. Holtmann G, Talley NJ, Goebell H. Association between H. pylori, duodenal mechanosensory thresholds and small intestinal motility in chronic unexplained dyspepsia. Dig Dis Sci 1996;41:1285-91.
28. Gardner M, Altman DG. Calculating confidence intervals for proportions and their differences. In: Gardner M, Altman DG, eds. Statistics with confidence: Confidence intervals and statistical guidelines. London: BMJ, 1991:28-33.
29. Fleiss JL. Statistical methods for rates and proportions, 2nd ed. London: Wiley, 1982:56-82.
30. Kruskal WH, Wallis WA. Use of ranks in one-criterion variance analysis. J Am Stat Assoc 1952;47:583-621.
31. SAS Institute IncSAS/STAT User's Guide, Release 603. Cary, NC: SAS Institute Inc. 1988.
32. Van Zanten SJOV, Cleary C, Talley NJ, et al. Drug treatment of functional dyspepsia: A systematic analysis of trial methodology with recommendations for design of future trials. Am J Gastroenterol 1996; 91:660-73.
33. Whitehead WE, Crowell MD, Bosmajian L, et al. Existence of irritable bowel syndrome supported by factor analysis of symptoms in two community samples. Gastroenterology 1990;98:336-40.
34. Kellow JE, Eckersley CM, Jones MP. Enhanced perception of physiological intestinal motility in the irritable bowel syndrome. Gastroenterology 1991;101:1621-7.
35. Trimble KC, Farouk R, Pryde A, et al. Heightened visceral sensaton in functional gastrointestinal disease is not site-specific: Evidence for a generalized disorder of gut sensitivity. Dig Dis Sci 1995;40:1607-13.
36. Lembo T, Munakata J, Mertz H, et al. Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome. Gastroenterology 1994;107:1686-96.
37. Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 1994;107:271-93.
38. Kendall GPM, Thompson DG, Day SJ. Motor responses of the small intestine to intraluminal distension in normal volunteers and a patient with visceral neuropathy. Gut 1987;28:714-20.