Exploring the uses of RNAi - Gene knockdown and the nobel prize

New England Journal of Medicine

Volumn 355, Issue 23, 2006, Pages 2391-2393

  Bernards, René ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; COMPLEMENTARY RNA; DOUBLE STRANDED RNA; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

AWARDS AND PRIZES; CAENORHABDITIS ELEGANS; CLINICAL TRIAL; DRUG TARGETING; GENE EXPRESSION; GENE SEQUENCE; GENE SILENCING; GENE TARGETING; HUMAN; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; SHORT SURVEY;

ANIMALS; DRUG DESIGN; DRUG RESISTANCE; GENE SILENCING; HISTORY, 21ST CENTURY; INTERFERONS; NOBEL PRIZE; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC; UNITED STATES;

EID: 33845412934     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMp068242     Document Type: Short Survey

References (4)

1. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806-11.
2. Ngo VN, Davis RE, Lamy L, et al. A loss-of-function RNA interference screen for molecular targets in cancer. Nature 2006;441:106-10.
3. Rottmann S, Wang Y, Nasoff M, Deveraux QL, Quon KCA. A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function. Proc Natl Acad Sci U S A 2005;102:15195-200.
4. Morris KV. Therapeutic potential of siRNA-mediated transcriptional gene silencing. Biotechniques 2006;Suppl:7-13.