Activity of HIV entry and fusion inhibitors expressed by the human vaginal colonizing probiotic Lactobacillus reuteri RC-14

Cellular Microbiology

Volumn 9, Issue 1, 2007, Pages 120-130

  Liu, Janice J ^a   Reid, Gregor ^b,c   Jiang, Yonghou ^a   Turner, Mark S ^d   Tsai, Che Chung ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; PROBIOTIC AGENT;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIUM CULTURE; CHROMOSOME INSERTION; CONTROLLED STUDY; GENE SEQUENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LACTOBACILLUS REUTERI; MOLECULAR CLONING; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RISK REDUCTION; SEQUENCE ANALYSIS; SEXUAL TRANSMISSION; VAGINA FLORA; VIRUS INHIBITION; VIRUS VIRULENCE;

ANIMALS; ARTIFICIAL GENE FUSION; BACTERIAL PROTEINS; FEMALE; GUINEA PIGS; HIV; HIV FUSION INHIBITORS; HIV INFECTIONS; HUMANS; LACTOBACILLUS FERMENTUM; LACTOBACILLUS REUTERI; LEUKOCYTES, MONONUCLEAR; MEMBRANE PROTEINS; PROBIOTICS; RECOMBINANT FUSION PROTEINS; VAGINA; VIRUS ATTACHMENT;

HUMAN IMMUNODEFICIENCY VIRUS 1; LACTOBACILLUS REUTERI;

EID: 33845408482     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2006.00772.x     Document Type: Article

References (28)

1. Alander, M., Satokari, R., Korpela, R., Saxelin, M., Vilpponen-Salmela, T., Mattila-Sandholm, T., and von Wright, A. (1999) Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption. Appl Environ Microbiol 65: 351-354.
2. Allaway, G.P., Davis-Bruno, K.L., Beaudry, G.A., Garcia, E.B., Wong, E.L., Ryder, A.M., et.al. (1995) Expression and characterization of CD4-IgG2, a novel heterotetramer that neutralizes primary HIV type 1 isolates. AIDS Res Hum Retroviruses 11: 533-539.
3. Aquaro, S., Menten, P., Struyf, S., Proost, P., Van Damme, J., De Clercq, E., and Schols, D. (2001) The LD78beta isoform of MIP-1alpha is the most potent CC-chemokine in inhibiting CCR5-dependent human immunodeficiency virus type 1 replication in human macrophages. J Virol 75: 4402-4406.
4. Cadieux, P., Burton, J., Gardiner, G., Braunstein, I., Bruce, A.W., Kang, C.Y., and Reid, G. (2002) Lactobacillus strains and vaginal ecology. JAMA 287: 1940-1941.
5. Chang, T.L., Chang, C.H., Simpson, D.A., Xu, Q., Martin, P.K., Lagenaur, L.A., et.al. (2003) Inhibition of HIV infectivity by a natural human isolate of Lactobacillus jensenii engineered to express functional two-domain CD4. Proc Natl Acad Sci USA 100: 11672-11677.
6. Conway, B. (2000) T-1249 trimeris. Curr Opin Anti-Infect Invest Drugs 2: 317-322.
7. Doleyres, Y., Beck, P., Vollenweider, S., and Lacroix, C. (2005) Production of 3-ydroxypropionaldehyde using a two-step process with Lactobacillus reuteri. Appl Microbiol Biotechnol 68: 467-474.
8. Eron, J.J., Gulick, R.M., Bartlett, J.A., Merigan, T., Arduino, R., Kilby, J., et.al. (2004) Short-term safety and antiretroviral activity of T-1249, a second-generation fusion inhibitor of HIV. J Infect Dis 189: 1075-1083.
9. Gan, B.S., Kim, J., Reid, G., Cadieux, P., and Howard, J.C. (2002) Lactobacillus fermentum RC-14 inhibits Staphylococcus aureus infection of surgical implants in rats. J Infect Dis 185: 1369-1372.
10. Jacobson, J.M., Israel, R.J., Lowy, I., Ostrow, N.A., Vassilatos, L.S., Barish, M., et.al. (2004) Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542. Antimicrob Agents Chemother 48: 423-429.
11. LaBranche, C.C., Galasso, G., Moore, J.P., Bolognesi, D.P., Hirsch, M.S., and Hammer, S.M. (2001) HIV fusion and its inhibition. Expert Opin Invest Drugs 9: 371-382.
12. Laughton, J.M., Devillardm, E., Heinrichs, D.E., Reid, G., and McCormick, J.K. (2006) Inhibition of expression of a staphylococcal superantigen-like protein by a secreted signalling factor from Lactobacillus reuteri. Microbiology 152: 1155-1167.
13. Medaglini, D., Pozzi, G., King, T.P., and Fischetti, V.A. (1995) Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization. Proc Natl Acad Sci USA 92: 6868-6872.
14. Medaglini, D., Rush, C.M., Sestini, P., and Pozzi, G. (1997) Commensal bacteria as vectors for mucosal vaccines against sexually transmitted diseases: Vaginal colonization with recombinant streptococci induces local and systemic antibodies in mice. Vaccine 15: 1330-1337.
15. Menten, P., Struyf, S., Schutyser, E., Wuyts, A., De Clercq, E., Schols, D., et.al. (1999) The LD78b isoform of MIP-1a is the most potent CCR5 agonist and HIV-1-inhibiting chemokine. J Clin Invest 104: R1-R5.
16. Morelli, L., Zonenenschain, D., Del Piano, M., and Cognein, P. (2004) Utilization of the intestinal tract as a delivery system for urogenital probiotics. J Clin Gastroenterol 38: S107-S110.
17. Nibbs, R.J., Yang, J., Landau, N.R., Mao, J.H., and Graham, G.J. (1999) LD78b, a non-allelic variant of human MIP-1a (LD78a), has enhanced receptor interactions and potent HIV suppressive activity. J Biol Chem 274: 17478-17483.
18. Pozzi, G., Oggioni, M.R., Manganelli, R., and Fischetti, V.A. (1992) Expression of M6 protein gene of Streptococcus pyogenes in Streptococcus gordonii after chromosomal integration and transcriptional fusion. Res Microbiol 143: 449-457.
19. Pusch, O., Boden, D., Hannify, S., Lee, F., Tucker, L.D., Boyd, M.R., et.al. (2005) Bioengineering lactic acid bacteria to secrete the HIV-1 virucide cyanovirin. J Acquir Immune Defic Syndr 15: 512-520.
20. Rao, S., Hu, S., McHugh, L., Lueders, K., Henry, K., Zhao, Q., et.al. (2005) Toward a live microbial microbicide for HIV: Commensal bacteria secreting an HIV fusion inhibitor peptide. Proc Natl Acad Sci USA 102: 11993-11998.
21. Reid, G., Charbonneau, D., Erb, J., Kochanowski, B., Beuerman, D., Poehner, R., and Bruce, A.W. (2003) Oral use of Lactobacillus rhamnosus GR-1 and L.fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women. FEMS Immunol Med Microbiol 35: 131-134.
22. Reimann, K.A., Li, J.T., Voss, G., Lekutis, C., Tenner-Racz, K., Racz, P., et.al. (1996) An env gene derived from a primary human immunodeficiency virus type 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys. J Virol 70: 3198-3206.
23. Turner, M.S., Woodberry, T., Hafner, L.M., and Giffard, P.M. (1999) The bspA locus of Lactobacillus fermentum BR11 encodes an 1-cystine uptake system. J Bacteriol 181: 2192-2198.
24. Turner, M.S., Hafner, L.M., Walsh, T., and Giffard, P.M. (2003) Peptide surface display and secretion using two LPXTG-containing surface proteins from Lactobacillus fermentum BR11. Appl Environ Microbiol 69: 5855-5863.
25. Turner, M.S., Hafner, L.M., Walsh, T., and Giffard, P.M. (2004) Identification and characterization of the novel LysM domain-containing surface protein Sep from Lactobacillus fermentum BR11 and its use as a peptide fusion partner in Lactobacillus and Lactococcus. Appl Environ Microbiol 70: 3673-3680.
26. Veazey, R.S., Klasse, P.J., Schader, S.M., Hu, Q., Ketas, T.J., Lu, M., et.al. (2005) Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor. Nature 438: 99-102.
27. Xu, Q., Lagenaur, L., Liu, X., Simpson, D., Essenmacher, K., Parker, C., et.al. (2005) Vaginal lactobacilli for mucosal delivery of the anti-HIV microbicide, cyanovirin (CV-N). Retrovirology 2: S87.
28. Zhu, P., Olson, W.C., and Roux, K.H. (2001) Structural flexibility and functional valence of CD4-IgG2 (PRO 542): Potential for cross-linking human immunodeficiency virus type 1 envelope spikes. J Virol 75: 6682-6686.