Synthesis and anti-HIV-1 activity of novel MKC-442 analogues containing alkenyl chains or reactive functionalities in the 6-benzyl group

Monatshefte fur Chemie

Volumn 137, Issue 12, 2006, Pages 1557-1570

  Aly, Youssef L ^a,c   Pedersen, Erik B ^a   La Colla, Paolo ^b   Loddo, Roberta ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c TANTA UNIVERSITY   (Egypt)

Author keywords

Bioorganic chemistry; Drug research; HIV 1; MKC 442; Non nucleoside

Indexed keywords

EID: 33845399019     PISSN: 00269247     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00706-006-0548-3     Document Type: Article

References (23)

1. De Clercq E (1998) Antiviral Res 38: 153
2. Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA (1992) Science 256: 1783
3. Ren J, Esnouf R, Garman E, Somers D, Ross C, Kirby I, Keeling J, Darby G, Jones Y, Stuart D, Stammers D (1995) Nat Struct Biol 2: 293
4. Ding J, Das K, Tantillo C, Zhang W, Clark ADJ, Jessen S, Lu X, Hsiou Y, Jacobo-Molina A, Andries K, Pauwels R, Moereels H, Koymans L, Janssen PAJ, Smith RHJ, Kroeger Koepke R, Michejda CJ, Hughes SH, Arnold E (1995) Structure 3: 365
5. Esnouf R, Ren J, Ross C, Jones Y, Stammers D, Stuart D (1995) Nat Sruct Biol 2: 303
6. http://www.aidsmeds.com/drugs/coactinon.htm
7. (a) Mai A, Artico M, Sbardella G, Massa S, Novellino E, Greco G, Loi AG, Tramontano E, Marongiu ME, La Colla P (1999) J Med Chem 42: 619;
8. (b) Mai A, Artico M, Sbardella G, Quartarone S, Massa S, Loi AG, De Montis A, Scintu F, Putzolu M, La Colla P (1997) J Med Chem 40: 1447
9. Mai A, Artico M, Ragno R, Sbardella G, Massa S, Musiu C, Mura M, Marturana F, Cadeddu A, Maga G, La Colla P (2005) Bio Med Chem 13: 2065
10. For recent reviews on anti-HIV agents, see: (a) Pedersen OS, Pedersen EB (2000) Synthesis 479;
11. (b) Pedersen OS, Pedersen EB (1999) Antiviral Chem Chemother 10: 285;
12. (c) De Clercq E (1998) Collect Czech Chem Commun 63: 449;
13. (d) Artico M (1996) 11 Farmaco 51: 305;
14. (e) De Clercq E (2005) current Opinion in Microbiology 8: 552;
15. (f) De Clercq E (2004) Chem Biodiversity 1: 44
16. Petersen L, Pedersen EB, Nielsen C (2001) Synthesis 559
17. Petersen L, Hansen TH, Khalifa NM, Jørgensen PT, Pedersen EB, Nielsen C (2002) Montatsh Chem 133: 1031
18. Breault GA, Oldfield J, Tucker H, Warner PW (1996) WO 9611902A1, CA 125: 114673
19. Danel K, Larsen E, Pedersen EB (1995) Synthesis 934
20. Johnson TB, Ambelang JC (1938) J Am Soc 60: 2941
21. Vorbrüggen H, Krolikiewiecz K, Bennua B (1981) Chem Ber 114: 1234
22. Pauwels R, Balzarini J, Baba M, Snoeck R, Schols D, Hederwijn P, Desmyster J, De Clercq E (1988) J Virol Methods 20: 309
23. The information in this document is provided as is and no guarantee or warranty is given that the information is fit for any particular purpose. The user thereof uses the information as its sole risk and liability