Catabolism of Adenine Nucleotides Favors Adenosine Production Following Exercise in Patients With Chronic Heart Failure

Journal of Cardiac Failure

Volumn 12, Issue 9, 2006, Pages 720-725

  Kinugawa, Toru ^a   Fujita, Masashi ^c   Ogino, Kazuhide ^a   Kato, Masahiko ^a   Osaki, Shuichi ^d   Igawa, Osamu ^a   Shigemasa, Chiaki ^a   Hisatome, Ichiro ^b   Kitakaze, Masafumi ^e  

^a TOTTORI UNIVERSITY   (Japan)

^b Institute of Regenerative Medicine and Biofunction   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d SAN IN ROSAI HOSPITAL   (Japan)

^e NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Adenosine; Ammonia; Heart failure; Purines

Indexed keywords

ADENINE NUCLEOTIDE DERIVATIVE; ADENOSINE; AMMONIA;

ADULT; AMMONIA BLOOD LEVEL; ARTICLE; BLOOD LEVEL; CARDIOVASCULAR RESPONSE; CATABOLISM; CONTROLLED STUDY; ERGOMETER; EXERCISE; EXERCISE TEST; EXPIRED AIR; FEMALE; GAS ANALYSIS; HEART FAILURE; HEART PROTECTION; HEART WORK; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ADENINE NUCLEOTIDES; ADENOSINE; AGED; AMMONIA; BLOOD PRESSURE; CARDIAC OUTPUT, LOW; CARDIOTONIC AGENTS; CHRONIC DISEASE; EXERCISE; FEMALE; HEART; HEART RATE; HUMANS; HYPOXANTHINE; LUNG; MALE; MIDDLE AGED; OXYGEN CONSUMPTION;

EID: 33845384111     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2006.08.215     Document Type: Article

References (22)

1. Hori M., and Kitakaze M. Adenosine, the heart, and coronary circulation. Hypertension 18 (1991) 565-574
2. Berne R.M. The role of adenosine in the regulation of coronary blood flow. Circ Res 47 (1980) 807-813
3. Kitakaze M., Node K., Komamura K., Minamino T., Kosaka H., Kuzuya T., et al. Intracoronary administration of adenosine triphosphate increases coronary blood flow and attenuates the severity of myocardial ischemic injury in dogs. Cardiovasc Drugs Ther 13 (1999) 407-414
4. Minamino T., Kitakaze M., Asanuma H., Tomiyama Y., Shiraga M., Sato H., et al. Endogenous adenosine inhibits P-selectin-dependent formation of coronary thromboemboli during hypoperfusion in dogs. J Clin Invest 101 (1998) 1643-1653
5. Fox I.H. Metabolic basis for disorders of purine nucleotide degradation. Metabolism 30 (1981) 616-634
6. Kinugawa T., Ogino K., Kato M., Kato T., Osaki S., Endo A., et al. Altered purine and glycogen metabolism in skeletal muscle during exercise in patients with heart failure. Metabolism 48 (1999) 484-488
7. Ogino K., Osaki S., Kitamura H., Noguchi N., Hisatome I., Matsumoto T., et al. Ammonia response to exercise in patients with congestive heart failure. Heart 75 (1996) 343-348
8. Funaya H., Kitakaze M., Node K., Minamino T., Komamura K., and Hori M. Plasma adenosine levels increase in patients with chronic heart failure. Circulation 95 (1997) 1363-1365
9. Sue D.Y., Wasserman K., Moricca R.B., and Casaburi R. Metabolic acidosis during exercise in patients with chronic obstructive pulmonary disease. Use of the V-slope method for anaerobic threshold determination. Chest 94 (1988) 931-938
10. Beaver W.L., Wasserman K., and Whipp B.J. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60 (1986) 2020-2027
11. Hisatome I., Kotake H., and Mashiba H. Determination of oxypurine and its clinical implication. Nippon Rinsho 48 Suppl (1989) 413-416
12. Costa F., Heusinkveld J., Ballog R., Davis S., and Biaggioni I. Estimation of skeletal muscle interstitial adenosine during forearm dynamic exercise in humans. Hypertension 35 (2000) 1124-1128
13. Lott M.E., Hogeman C.S., Vickery L., Kunselman A.R., Sinoway L.I., and MacLean D.A. Effects of dynamic exercise on mean blood velocity and muscle interstitial metabolite responses in humans. Am J Physiol Heart Circ Physiol 281 (2001) H1734-H1741
14. Gross M. Molecular biology of AMP deaminase deficiency. Pharm World Sci 16 (1994) 55-61
15. Sabina R.L., Swain J.L., Olanow C.W., Bradley W.G., Fishbein W.N., DiMauro S., et al. Myoadenylate deaminase deficiency. Functional and metabolic abnormalities associated with disruption of the purine nucleotide cycle. J Clin Invest 73 (1984) 720-730
16. Kalsi K.K., Yuen A.H., Rybakowska I.M., Johnson P.H., Slominska E., Birks E.J., et al. Decreased cardiac activity of AMP deaminase in subjects with the AMPD1 mutation-a potential mechanism of protection in heart failure. Cardiovasc Res 59 (2003) 678-684
17. Kitakaze M., Hori M., Morioka T., Minamino T., Takashima S., Okazaki Y., et al. Alpha 1-adrenoceptor activation increases ecto-5′-nucleotidase activity and adenosine release in rat cardiomyocytes by activating protein kinase C. Circulation 91 (1995) 2226-2234
18. Kinugawa T., Ogino K., Kitamura H., Miyakoda H., Saitoh M., Hasegawa J., et al. Response of sympathetic nervous system activity to exercise in patients with congestive heart failure. Eur J Clin Invest 21 (1991) 542-547
19. Zoref-Shani E., Kessler-Icekson G., Wasserman L., and Sperling O. Characterization of purine nucleotide metabolism in primary rat cardiomyocyte cultures. Biochim Biophys Acta 804 (1984) 161-168
20. Bowditch J., Nigdikar S., Brown A.K., and Dow J.W. 5′ Nucleotidase activity of isolated nature rat cardiac myocytes. Biochim Biophys Acta 845 (1985) 21-26
21. Kitakaze M., Minamino T., Node K., Koretsune Y., Komamura K., Funaya H., et al. Elevation of plasma adenosine levels may attenuate the severity of chronic heart failure. Cardiovasc Drugs Ther 12 (1998) 307-309
22. Loh E., Rebbeck T.R., Mahoney P.D., DeNofrio D., Swain J.L., and Holmes E.W. Common variant in AMPD1 gene predicts improved clinical outcome in patients with heart failure. Circulation 99 (1999) 1422-1425