Plasma cobalamin and folate and their metabolic markers methylmalonic acid and total homocysteine among Egyptian children before and after nutritional supplementation with the probiotic bacteria Lactobacillus acidophilus in yoghurt matrix

International Journal of Food Sciences and Nutrition

Volumn 57, Issue 7-8, 2006, Pages 470-480

  Mohammad, Mahmoud A ^a   Molloy, Anne ^b   Scott, John ^b   Hussein, Laila ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Egyptian children; Folate; Homocysteine; Lactobacillus acidophilus; Nutritional intervention; Urinary methylmalonic acid; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HEMOGLOBIN; HOMOCYSTEINE; METHYLMALONIC ACID; PROBIOTIC AGENT; YOGHURT;

ANEMIA; ARTICLE; BLOOD SAMPLING; CHILD NUTRITION; CLINICAL ARTICLE; CLINICAL TRIAL; COLONY FORMING UNIT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DIET SUPPLEMENTATION; EGYPT; FEMALE; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; FOOD INTAKE; HEMOGLOBIN DETERMINATION; HUMAN; LACTOBACILLUS ACIDOPHILUS; MALE; NUTRIENT CONTENT; NUTRIENT SUPPLY; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; NUTRITIONAL VALUE; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SCHOOL CHILD; URINALYSIS; VITAMIN BLOOD LEVEL;

CHI-SQUARE DISTRIBUTION; CHILD; DIETARY SUPPLEMENTS; EGYPT; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; LACTOBACILLUS ACIDOPHILUS; MALE; METHYLMALONIC ACID; PROBIOTICS; TREATMENT OUTCOME; VITAMIN B 12; VITAMIN B 12 DEFICIENCY; YOGURT;

LACTOBACILLUS ACIDOPHILUS;

EID: 33845379920     PISSN: 09637486     EISSN: 14653478     Source Type: Journal    
DOI: 10.1080/09637480600968735     Document Type: Article

References (40)

1. Abdel-Aziz S, Hussein L, 2005. Evaluation of vitamin B12 status in Egypt IV: Food consumption patterns among lactating mothers and their impact on the intake of the vitamin. Int J Food Sci Nutr 56: 455-462.
2. Allen, RH and Stabler, SP and Savage, DG and Lindenbaum, J. (1990) Diagnosis of cobalamin deficiency. I. Usefulness of serum methylmalonic acid and total homocysteine concentrations Am J Hematol, 34, pp. 90-98.
3. Allen, RH and Stabler, SP and Savage, DG and Lindenbaum, J. (1993) Metabolic abnormalities in cobalamin (vitamin-B12) and folate deficiency FASEB J, 7, pp. 1344-1353.
4. Barness, LA and Young, D and Mellman, WJ and Kahn, SB and Williams, WJ. (1963) Methylmalonate excretion in a patient with pernicious anemia N Engl J Med, 268, pp. 144-146.
5. Bjorke Monsen, AL and Ueland, PM. (2003) Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence Am J Clin Nutr, 78, pp. 7-21.
6. Crittenden, RG and Martinez, NR and Playne, MJ. (2003) Synthesis and utilization of folate by yoghurt starter cultures and probiotic bacteria Int J Food Microbiol, 80, pp. 217-222.
7. De Laet, C and Wautrecht, J-C and Brasseur, D and Dramaix, M and Boeynaems, J-M and Decuyper, J and Kahn, A. (1999) Plasma homocysteine concentrations in a Belgian school-age population Am J Clin Nutr, 69, pp. 968-972.
8. Dietary Reference Intakes. (1998) Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B 6, folate, vitamin B 12, pantothenic acid, biotin, and choline. Washington DC: National Academy Press.
9. Donaldson, MS. (2000) Metabolic vitamin B-12 status on a mostly raw vegan diet with follow-up using tablets, nutritional yeast or probiotic supplements Ann Nutr Metabolism, 44, pp. 229-234.
10. Elmadfa, I and Heinzle, C and Majchrzak, D and Foissy, H. (2001) Influence of a probiotic yoghurt on the status of vitamins B1, B2 and B6 in the healthy adult human Ann Nutr Metab, 45, pp. 13-18.
11. FAO/WHO. (2002) Folate and folic acid. In Human vitamin and mineral requirements. Report of a Joint FAO/WHO Expert Consultation. (pp. 53-63). Rome: FAO.
12. Frosst, P and Blom, HJ and Milos, R and (1995) A candidate genetic risk factor for vascular disease: A common mutation in methylene-tetrahydrofolate reductase Nat Genet, 10, pp. 111-113.
13. Herbert, V and Drivas, G and Manusselis, C and Mackler, M and Eng, J and Schwartz, E. (1984) Are colon bacteria a major source of cobalamin analogues in human tissues? 24-h human stool contains only about 5 μg of cobalamin but about 100 μg of apparent analogues (and 200 μg) folate Trans Assoc Am Phys, 97, pp. 161-171.
14. Herbert, V. (1994) Staging vitamin B-12 (cobalamin) status in vegetarians Am J Clin Nutr, 59, pp. 1213S-1222S.
15. Herrmann, W and Schorr, H and Purschwitz, K and Rassoul, F and Richter, V. (2001) Total homocysteine, vitamin B12 and total antioxidant status in vegetarians Clin Chem, 47, pp. 1094-1101.
16. Hjelt, K and Paerregaard, A and Krasilnikoff, PA. (1992) Giardiasis: Haematological status and the absorption of vitamin B12 and folic acid Acta Paediatr, 81, pp. 29-34.
17. 12 Proc R Soc, A266, pp. 475.
18. Hokin, BD and Butler, T. (1999) Cyanocobalamin (vitamin B-12) status in Seventh-day Adventist ministers in Australia Am J Clin Nutr, 79, pp. 576S-578S.
19. Holleland, G and Schneede, J and Ueland, PM and Lund, PK and Refsum, H and Sandberg, S. (1999) Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies Clin Chem, 45, pp. 189-198.
20. Husek, P. (1995) Simultaneous profile analysis of plasma amino and organic acids by capillary gas chromatography J Chromatogr B Biomed Appl, 669, pp. 352-357.
21. Jacob, RA. (2000) Folate, DNA methylation and gene expression: Factors of nature and nurture Am J Clin Nutr, 72, pp. 903-904.
22. Kelleher, BP and O'Broin, SD. (1991) Microbiological assay for vitamin B12 performed in 96-well microtitre plates J Clin Pathol, 44, pp. 592-595.
23. Krause, LJ and Forsberg, CW and O'Connor, DL. (1996) Feeding human milk to rats increases Bifidobacterium in the cecum and colon which correlates with enhanced folate status J Nutr, 126, pp. 1505-1511.
24. Lourens-Hattingh, A and Viljoen, BC. (2001) Yogurt as probiotic carrier food Int Dairy J, 11, pp. 1-17.
25. Lucock, MD and Priestnal, M and Daskalakis, I and Schorah, CJ and Wild, J and Levene, MI. (1995) Nonenzymatic degradation and salvage of dietary folate: Physicochemical factors likely to influence bioavailability Biochem Mol Med, 55, pp. 43-53.
26. 12 Am J Clin Nutr, 34, pp. 1611-1616.
27. Molloy, AM and Scott, JM. (1997) Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method Methods Enzymol, 281, pp. 43-53.
28. 12 analogues Br J Haematol, 62, pp. 7-12.
29. Neuhouser, ML and Beresford, SA. (2001) Folic acid: Are current fortification levels adequate? Nutrition, 17, pp. 868-872.
30. O'Broin, S and Kelleher, B. (1992) Microbiological assay on microtitre plates of folate in serum and red cells J Clin Pathol, 45, pp. 344-347.
31. Refsum, H and Ueland, PM and Nygard, O and Vollset, SE. (1998) Homocysteine and cardiovascular disease Ann Rev Med, 49, pp. 31-62.
32. Refsum, H and Smith, D and Ueland, PM and Nexo, E and Clarke, R and McPartlin, J and Johnston, C and Engbaek, F and Schneede, J and McPartlin, C and Scott, J. (2004) Facts and recommendations about total homocysteine determinations: An expert opinion Clin Chem, 50, pp. 3-32.
33. Sepehr, E and Peace, RW and Storey, KB and Jee, P and Lampi, BJ and Brooks, SPJ. (2003) Folate derived from cecal bacterial fermentation does not increase liver folate sotores in 28-d folate depleted male Sprague Dawley rats J Nutr, 133, pp. 1347-1354.
34. Speck, ML. (1978) Enumeration of viable Lactobacillus acidophilus organisms in dairy products J Food Protection, 41, pp. 135-137.
35. Stabler, SP and Marcell, PD and Podell, ER and Allen, RH and Savage, DG and Lindenbaum, J. (1988) Elevation of total homocysteine in the serum of patients with cobalamin of folate deficiency detected by capillary gas chromatography-mass spectrometry J Clin Invest, 81, pp. 466-474.
36. Sybesma, WM and Starrenburg, L and Tijsseling, MHN and Hoefnagel Hugenholtz, J. (2003) Effects of growth conditions on folate production by lactic acid bacteria Appl Environ Microbiol, 69, pp. 4542-4548.
37. Verhoef, P and Stampfer, MJ and Buring, JE and Gaziano, JM and Allen, RH and Stabler, SP and Reynolds, RD and Kok, FJ and Hennekens, CH and Willett, WC. (1996) Homocysteine metabolism and risk of myocardial infarction: Relation with vitamins B6, B12 and folate Am J Epidemiol, 143, pp. 845-859.
38. Wegkamp, A and Starrenburg, M and de Vos, W and Hugenholtz, J and Sybesma, W. (2004) Transformation of folate-consuming Lactobacillus gasseri into a folate producer Appl Environ Microbiol, 70, pp. 3146-3148.
39. Welcch, GN and Loscalzo, J. (1998) Homocysteine and atherothrombosis N Engl J Med, 338, pp. 1042-1050.
40. Woltersdorf, WW and Bowron, A and Day, AP and Scott, J and Stansbie, D. (1999) Abbott IMx homocysteine assay: Significant interference by 3-deazaadenosine Ann Clin Biochem, 36, pp. 533.