Effect of antibacterial honey on the ocular flora in tear deficiency and meibomian gland disease

Cornea

Volumn 25, Issue 9, 2006, Pages 1012-1019

  Albietz, Julie M ^a,c   Lenton, Lee M ^b  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b River City ^*

^c Pine Rivers Eye Centre   (Australia)

Author keywords

Antibacterial honey; Aqueous tear deficiency; Dry eye; Meibomian gland disease

Indexed keywords

MEDIHONEY; NATURAL PRODUCT;

ADULT; AGED; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM ISOLATION; CHRONIC DISEASE; COLONY FORMING UNIT; CONTROLLED STUDY; DRY EYE; EYELID; FEMALE; HONEY; HUMAN; MAJOR CLINICAL STUDY; MEIBOMIAN GLAND; MEIBOMIAN GLAND DISEASE; OPEN STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE;

ADMINISTRATION, TOPICAL; ANTI-INFECTIVE AGENTS, LOCAL; BACTERIA; COLONY COUNT, MICROBIAL; CONJUNCTIVA; DRY EYE SYNDROMES; EYELID DISEASES; EYELIDS; FEMALE; HONEY; HUMANS; MALE; MEIBOMIAN GLANDS; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES; TEARS;

EID: 33845357144     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ico.0000225716.85382.7b     Document Type: Article

References (45)

1. Gethin G. Is there enough clinical evidence to use honey to manage wounds? J Wound Care. 2004;13:275-278.
2. Molan P. The role of honey in the management of wounds. J Wound Care. 1999;8:415-418.
3. Al-Waili NS. Investigating the antimicrobial activity of natural honey and its effects on the pathogenic bacterial infections of surgical wounds and conjunctiva. J Med Food. 2004;7:210-222.
4. Mansour AM. Corneal oedema treated with honey. Clin Experiment Ophthalmol. 2002;30:149-150.
5. Mozherenkov VP, Miniaeva TG. The use of products from bee raising in ophthalmology and otorhinolaryngology (Russian). Med Sestra. 1991;50:47-51.
6. Popescu MP, Palos E, Popescu F. Efficacy of combined biological therapy with bee products in localized palpebral and conjunctival eye lesions with reference to the clinico-functional changes. (Russian). Rev Oftalmol. 1985;29:53-61.
7. Dougherty JM, McCulley JP. Bacterial lipases and chronic blepharitis. Invest Ophthalmol Vis Sci. 1986;27:486-491.
8. Bowman RW, Dougherty JM, McCulley JP. Chronic blepharitis and dry eyes. Int Ophthalmol Clin. 1987;27:27-35.
9. Groden LR, Murphy B, Rodnite J, et al. Lid flora in blepharitis. Cornea. 1991;10:50-53.
10. Houang E, Lam D, Fan D, et al. Microbial keratitis in Hong Kong: relationship to climate, environment and contact-lens disinfection. Trans R Soc Trop Med Hyg. 2001;95:361-367.
11. Huang SC, Wu SC, Wu WC, et al. Microbial keratitis - a late complication of penetrating keratoplasty. Trans R Soc Trop Med Hyg. 2000;94:315-317.
12. Scott IU, Flynn HW Jr, Feuer W, et al. Endophthalmitis associated with microbial keratitis. Ophthalmology. 1996;103:1864-1870.
13. Blair S, Carter DA. Honey and drug resistant pathogens. Paper presented at: Joint Scientific Meeting of the Australian Society for Microbiology; July 2000; Cairns, Queensland, Australia.
14. George N, Sturgess R, Foagagali J, et al. Honey Vantimicrobial agents au naturel. Paper presented at: Australian Infection Control Association Third Biennial Conference; June 2004; Hobart, Australia.
15. Fleiszig SM, Efron N. Microbial flora in eyes of current and former contact lens wearers. J Clin Microbiol. 1992;30:1156-1161.
16. Rubio EF. Climatic influence on conjunctival bacteria of patients undergoing cataract surgery. Eye. 2004;18:778-784.
17. Lemp MA. Report on the National Eye Institute/Industry Workshop on Clinical Trials in Dry Eyes. CLAO J. 1995;21:221-232.
18. McMonnies CW. Key questions in a dry eye history. J Am Optom Assoc. 1986;57:512-517.
19. Bron AJ. The Doyne Lecture: reflections on the tears. Eye. 1997;11:583-602.
20. Hykin PG, Bron AJ. Age related morphological changes in the lid margin and meibomian gland anatomy. Cornea. 1992;11:334-342.
21. Thiel HJ, Schumacher U. Normal flora of the human conjunctiva: examination of 135 persons of various ages. (German). Klin Monatsbl Augenheilkd. 1994;205:348-357.
22. Postmes TAE, van den Bogaard, Hazen M. The sterilization of honey with cobalt 60 gamma radiation: a study of honey spiked with spores of Clostridium botulinum and Bacillus subtilis. Experimenta. 1995;51:986-989.
23. Granato PA. Pathogenic and indigenous microorganisms of humans. In: Murray P, ed. Manual of Clinical Microbiology. Vol. 1, 6th ed. American Society for Microbiology, Washington, D.C., 1995:14-15.
24. Groden LR, Murphy B, Rodnite J, et al. Lid flora in blepharitis. Cornea. 1991;10:50-53.
25. Gritz DC, Scott TJ, Sedó SF. Ocular flora of patients with AIDS compared with those of HIV-negative patients. Cornea. 1997;16:400-405.
26. Ta CN, Shine WE, McCulley JP, et al. Effects of minocycline on the ocular flora of patients with acne rosacea or seborrheic blepharitis. Cornea. 2003;22:545-548.
27. Seal DV, McGill JI, Mackie IA, et al. Bacteriology and tear protein profiles of the dry eye. Br J Ophthalmol. 1986;70:122-125.
28. Kiratli H, Irkec M, Orhan M. Tear lactoferrin levels in chronic meibomitis associated with acne rosacea. Eur J Ophthalmol. 2000;10:11-14.
29. Seamone CD, Jackson WB. Immunology of the external eye. In: Tasman W, Jaeger EA, eds. Clinical Ophthalmology. Philadelphia, PA: Lippincott-Raven; 1997:1-52.
30. Pflugfelder SC, Tseng SC, Sanabria O, et al. Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea. 1998;17:38-56.
31. Shimazaki J, Goto E, Ono M, et al. Meibomian gland dysfunction in patients with Sjogren syndrome. Ophthalmology. 1998;105:1485-1488.
32. Stern ME, Beurerman RW, Fox RI, et al. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998;17:584-589.
33. Ohashi Y, Ishida R, Kojima T, et al. Abnormal protein profiles in tears with dry eye syndrome. Am J Ophthalmol. 2003;136:291-299.
34. McCulley JP, Dougherty JM. Bacterial aspects of chronic blepharitis. Trans Ophthalmol Soc U K. 1986;105:314-318.
35. Mahajan VM. Acute bacterial infections of the eye: their aetiology and treatment. Br J Ophthalmol. 1983;67:191-194.
36. Molan PC. The antibacterial activity of honey. 1. The nature of the antibacterial activity. Bee World. 1992;73:5-28.
37. Bang LM, Buntting C, Molan P. The effect of dilution on the rate of hydrogen peroxide production in honey and its implications for wound healing. J Alternat Complement Med. 2003;9:267-273.
38. Riley MV, Wilson G. Topical hydrogen peroxide and the safety of ocular tissues. CLAO J. 1993;19:186-190.
39. Molan PC. The antibacterial activity of honey. 2. Variation in the potency of the antibacterial activity. Bee World. 1992;73:59-76.
40. Wilkinson JM, Cavanagh HMA. Antibacterial activity of 13 honeys against Escherichia coli and Pseudomonas aeruginosa. J Med Food. 2005;8:100-103.
41. Davis C. Antimicrobial Properties of Australian Honeys - Final Report. A report by the Rural Industries Research and Development Corporation, Centre for Food Technology; Brisbane, Australia, July 1997.
42. Allen KL, Molan PC, Reid GM. A survey of the antibacterial activity of some New Zealand honeys. J Pharm Pharmacol. 1991;42:817-822.
43. Tonks AJ, Cooper RA, Jones KP, et al. Honey stimulates inflammatory cytokine production from monocytes. Cytokine. 2003;21:242-247.
44. Ermis SS, Aktepe OC, Inan UU, et al. Effect of topical dexamethasone and ciprofloxacin on bacterial flora of healthy conjunctiva. Eye. 2004;18:249-252.
45. Mino de Kaspar H, Shriver EM, Nguyen EV, et al. Risk factors for antibiotic-resistant conjunctival bacterial flora in patient undergoing intraocular surgery. Graefes Arch Clin Exp Ophthalmol. 2003;241:730-733.