Antibiotics and anaerobes of gut origin

Current Opinion in Microbiology

Volumn 6, Issue 5, 2003, Pages 457-461

  Vedantam, Gayatri ^a,b   Hecht, David W ^a,b  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b HINES VA HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CARBAPENEM DERIVATIVE; CEFOTETAN; CEFOXITIN; CEPHALOSPORIN; CHLORAMPHENICOL; CLINDAMYCIN; ERTAPENEM; IMIPENEM; MEROPENEM; METRONIDAZOLE; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; QUINOLONE DERIVATIVE; STREPTOMYCIN; SULTAMICILLIN; TETRACYCLINE DERIVATIVE; TIMENTIN; TROVAFLOXACIN;

AEROBIC BACTERIUM; ANAEROBIC BACTERIUM; ANTIBIOTIC RESISTANCE; BACTERIAL INFECTION; BACTEROIDES FRAGILIS; CLOSTRIDIUM BUTYRICUM; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM PERFRINGENS; DNA TRANSFER; DRUG MECHANISM; FUSOBACTERIUM; INTESTINE CANCER; INTESTINE DIVERTICULOSIS; INTESTINE FLORA; INTESTINE PERFORATION; INTESTINE SURGERY; OPPORTUNISTIC INFECTION; PREVOTELLA; REVIEW;

BACTERIA (MICROORGANISMS); BACTEROIDES; BACTEROIDES FRAGILIS; CLOSTRIDIUM; CLOSTRIDIUM BUTYRICUM; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM PERFRINGENS; FUSOBACTERIUM; PREVOTELLA;

EID: 0242323602     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mib.2003.09.006     Document Type: Review

References (28)

1. Duerden BI: Virulence factors in anaerobes. Clin Infect Dis 1994, 18:S253-S259.
2. Hecht DW, Finegold S: Perotinitis and intra-abdominal abscess. In Infections of the Gastrointestinal Tract, edn 2. Edited by Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL. Philadelphia: Lipincott, Williams and Wilkins; 2003:317-349.
3. Hecht DW, Vedantam G, Osmolski JR: Antibiotic resistance among anaerobes: What does it mean? Anaerobe 1999, 5:421-429.
4. Nguyen MH, Yu VL, Morris AJ, McDermott L, Wagener MW, Harrell L, Snydman DR: Antimicrobial resistance and clinical outcome of Bacteroides bacteremia: findings of a multicenter prospective observational trial. Clin Infect Dis 2000, 30:870-876.
5. th. Approved, M11-A5. 2001.
6. Snydman DR, Jacobus NV, McDermott LA, Ruthazer R, Goldstein E, Finegold S, Harrell L, Hecht DW, Jenkins S, Pierson C et al.: In vitro activities of newer quinolones against Bacteroides group organisms. Antimicrob Agents Chemother 2002, 46:3276-3279. This paper reports the rapid rise in minimum inhibitory concentrations and resistance for many recently introduced quinolone antibiotics.
7. Snydman DR, Jacobus NV, McDermott LA, Ruthazer R, Goldstein EJ, Finegold SM, Harrell LJ, Hecht DW, Jenkins SG, Pierson C et al.: National survey on the susceptibility of Bacteroides fragilis Group: report and analysis of trends for 1997-2000. Clin Infect Dis 2002, 35:S126-S134.
8. Scott KP: The role of conjugative transposons in spreading antibiotic resistance between bacteria that inhabit the gastrointestinal tract. Cell Mol Life Sci 2002, 59:2071-2082. This paper reports that anaerobic bacteria of the human gastrointestinal tract can serve as reservoirs of antibiotic resistance genes, many of which are carried by mobile genetic elements. Evidence that gene transfer may occur between these reservoirs and various pathogenic bacteria is also presented.
9. Salyers AA: Beware the commensals: Their role in antibiotic resistance spread may be greater then we think. ASM News. 1999.
10. Rasmussen J, Gluzman Y, Tally FP: Escherichia coli chromosomal mutations that permit direct cloning of the Bacteroides fragilis metallo-β-lactamase gene, ccrA. Mol Microbiol 1991, 5:1211-1219.
11. Cuchural GJ, Tally FP, Jacobus NV, Cleary TJ, Finegold SM, Hills GB, Iannini PB, O'Keefe JP, Pierson CL: Comparative activities of newer beta-lactam agents against members of the Bacteroides fragilis group. Antimicrob Agents Chemother 1990, 34:479-480.
12. Wexler HM: Outer-membrane pore-forming proteins in Gram-negative anaerobic bacteria. Clin Infect Dis 2002, 35:S65-S71.
13. Speer BS, Bedzyk L, Salyers AA: Evidence that a novel tetracycline resistance gene found on two Bacteroides transposons encodes an NADP-requiring oxidoreductase. J Bacteriol 1991, 173:176-183.
14. Rasmussen BA, Bush K, Tally FP: Antimicrobial resistance in anaerobes. Clin Infect Dis 1997, 24(Suppl 1):S110-S120.
15. Higgins PG, Fluit AC, Schmitz FJ: Fluoroquinolones: structure and target sites. Curr Drug Targets 2003, 4:181-190.
16. Hooper DC: Emerging mechanisms of fluoroquinolone resistance. Clin Infect Dis 2001, 7:337-341.
17. Tran JH, Jacoby GA: Mechanism of plasmid-mediated quinolone resistance. Proc Natl Acad Sci USA 2002, 99:5638-5642.
18. Martinez-Martinez L, Pascual A, Jacoby GA: Quinolone resistance from a transferable plasmid. Lancet 1998, 351:797-799.
19. Whittle G, Shoemaker NB, Salyers AA: The role of Bacteroides conjugative transposons in the dissemination of antibiotic resistance genes. Cell Mol Life Sci 2002, 59:2044-2054. This paper reports that members of the genus Bacteroides harbor a plethora of mobile genetic elements and provides an updated list of these elements. Extensive information on the class of elements known as conjugative transposons is also presented.
20. Smith CJ, Tribble GD, Bayley DP: Genetic elements of Bacteroides species: a moving story. Plasmid 1998, 40:12-29.
21. Whittle G, Hund BD, Shoemaker NB, Salyers AA: Characterization of the 13-kilobase ermF region of the Bacteroides conjugative transposon CTnDOT. Appl Environ Microbiol 2001, 67:3488-3495.
22. Vedantam G, Hecht DW: Isolation and characterization of BTF-37: chromosomal DNA captured from Bacteroides fragilis that confers self-transferability and expresses a pilus-like structure in Bacteroides spp. and Escherichia coli 1. J Bacteriol 2002, 184:728-738. This paper is the first to describe an antibiotic inducible conjugation apparatus, including a cell-surface structure that appears to be involved in cell-cell attachment during conjugation.
23. Salyers AA, Shoemaker NB, Li LY, Stevens AM: Conjugative transposons: an unusual and diverse set of integrated gene transfer elements. Microbiol Rev 1995, 59:579-590.
24. Stevens AM, Shoemaker NB, Li LY, Salyers AA: Tetracycline regulation of genes on Bacteroides conjugative transposons. J Bacteriol 1993, 175:6134-6141.
25. Valentine PJ, Shoemaker NB, Salyers AA: Mobilization of Bacteroides plasmids by Bacteroides conjugal elements. J Bacteriol 1988, 170:1319-1324.
26. Shoemaker NB, Vlamakis H, Hayes K, Salyers AA: Evidence for extensive resistance gene transfer among Bacteroides spp. and among Bacteroides and other genera in the human colon. Appl Environ Microbiol 2001, 67:561-568.
27. Nikolich MP, Hong G, Shoemaker NB, Salyers AA: Evidence for natural horizontal transfer of tetQ between bacteria that normally colonize humans and bacteria that normally colonize livestock. Appl Environ Microbiol 1994, 60:3255-3260.
28. Wang Y, Wang GR, Shelby A, Shoemaker NB, Salyers AA: A newly discovered Bacteroides conjugative transposon, CTnGERM1, contains genes also found in Gram-positive bacteria. Appl Environ Microbiol 2003, 69:4595-4603.