Characterization of an etoposide-glutathione conjugate derived from metabolic activation by human cytochrome P450

Current Drug Metabolism

Volumn 7, Issue 8, 2006, Pages 897-911

  Zheng, Naiyu ^a,b   Pang, Shaokun ^a,c   Oe, Tomoyuki ^a   Felix, Carolyn A ^a   Wehrli, Suzanne ^a   Blair, Ian A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c Takeda San Diego Inc   (United States)

Author keywords

Cytochrome P450; Etoposide catechol; Etoposide metabolism; Etoposide quinone; Glutathione conjugate; Human liver microsomes; Mass spectrometry; NMR spectroscopy

Indexed keywords

CYTOCHROME P450; DRUG METABOLITE; ETOPOSIDE; ETOPOSIDE CATECHOL; ETOPOSIDE DERIVATIVE; ETOPOSIDE QUINONE; ETOPOSIDE SIMIQUINONE; GLUTATHIONE; QUINONE DERIVATIVE; RECOMBINANT ENZYME;

CHEMICAL REACTION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DETERMINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER MICROSOME; MASS SPECTROMETRY; METABOLIC ACTIVATION; MICHAEL ADDITION; NUCLEAR MAGNETIC RESONANCE; REVIEW;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ETOPOSIDE; GLUTATHIONE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSOMES, LIVER;

EID: 33845347814     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920006779010638     Document Type: Review

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