Ring substituent effects on biological activity of vinyl sulfones as inhibitors of HIV-1

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 2, 2007, Pages 1127-1137

  Meadows, D Christopher ^a,c   Sanchez, Tino ^b   Neamati, Nouri ^b   North, Thomas W ^c   Gervay Hague, Jacquelyn ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

HIV integrase; HIV 1; Vinyl sulfones

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BIS(2 METHANESULFONYLETHYL)BENZENE; BIS(2 METHANESULFONYLVINYL)BENZENE; BIS(BETA 1 INDOLE 5 STYRENESULFONYL)METHANE; BIS(BETA 2,4,5 TRIMETHOXYSTYRENESULFONYL)METHANE; BIS(BETA 3,4 METHOXY 6 NITROSTYRENESULFONYL)METHANE; BIS(BETA 3,4,5 TRIFLUOROSTYRENESULFONYL)METHANE; BIS(BETA 4 CARBOXYSTYRENESULFONYL)METHANE; BIS(BETA 6 BROMO 3,4 DIMETHOXYSTYRENESULFONYL)METHANE; BIS[1 BENZYLOXY 2 (2 METHANESULFONYLVINYL)BENZENE]; BIS[1 BROMO 5 (2 METHANESULFONYLVINYL) 2,3 DIMETHOXYBENZENE]; BIS[1,2 BENZYLOXY 5 (2 ETHANESULFONYLVINYL)BENZENE]; BIS[1,2,3 BENZYLOXY(2 ETHANESULFONYLVINYL)BENZENE]; BIS[1,4 DICHLORO 2 (2 METHANESULFONYLVINYL)BENZENE]; BIS[2 (3,4 DIHYDROXYPHENYL)ETHYLSULFONYL]METHANE; BIS[2 (3,4,5 TRIFLUOROPHENYL)ETHYLSULFONYL]METHANE; BIS[2 BROMO 6 (2 METHANESULFONYLVINYL)PYRIDINE]; BIS[4 BROMO 2 (2 METHANESULFONYLVINYL) 1 METHOXYBENZENE]; BIS[6 (2 METHANESULFONYLVINYL) 2,3 DIHYDROBENZO[1,4]DIOXINE]; SULFONE DERIVATIVE;

ADDITION REACTION; ANTIVIRAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SAFETY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON TRANSPORT; HUMAN IMMUNODEFICIENCY VIRUS 1; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; IMMUNOASSAY; INDICATORS AND REAGENTS; MASS SPECTROMETRY; OLIGONUCLEOTIDES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; VINYL COMPOUNDS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33845338808     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.017     Document Type: Article

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