The milky spots of the peritoneum and pleura: Structure, development and pathology

Biomedical Reviews

Volumn 15, Issue 1, 2004, Pages 47-66

  Michailova, Krassimira N ^a   Usunoff, Kamen G ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33845313098     PISSN: 1310392X     EISSN: None     Source Type: Journal    
DOI: 10.14748/bmr.v15.102     Document Type: Review

References (182)

1. von Recklinghausen F. Über Eiter-Bindegewebskoerperchen. Virchows Arch Pathol Anat 1863; 28: 157-166.
2. Liebermann-Meffert D, White H, editors. The Greater Omentum. Anatomy, Physiology, Pathology, Surgery, Historical Survay. Springer-Verlag, Berlin, 1983.
3. Ranvier L. Du developpement et de l'accroisement des vaisseaux sanguins. Arch Physiol Norm Pathol 1874; 6: 429-449.
4. Morrison R. Functions of the omentum. Br Med J 1906; 76-78.
5. Walker FC. The protective function of the greater omentum. Ann Roy Coll Surg Engl 1963; 33: 282-306.
6. Hamazaki Y. Comparative studies on the milky spots, "taches laiteuses" of various animals. Folia Anat. Jpn 1925; 3: 243-265.
7. Dux K. Role of the greater omentum in the immunological response of mice and rats to the intraperitoneal inoculation of Ehrlich ascites tumor. Arch Immunol Ther Exp 1969; 17: 425-432.
8. Takemori N, Hirai K, Onodera R, Saito N, Namiki M. Light and electron microscopic study of omental milky spots in New Zealand Black mice, with special reference to the extramedullary hematopoiesis. Anat Embryol 1994; 189: 215-226.
9. Hodel C. Ultrastructural studies on the absorption of protein markers by the greater omentum. Eur Surg Res 1970; 2: 435-449.
10. Watanabe K, Masubuchi S, Kageyama K. Ultrastructural localization of peroxidase in mononuclear phagocytes from the peritoneal cavity, blood, bone marrow and omentum, with a special reference to the origin of peritoneal macrophages. Recent Adv RES Res 1973; 11: 120-144.
11. Beelen RHJ, Fluitsma DM, Hoefsmit ECM. The cellular composition of omentum milky spots and the ultrastructure of milky spot macrophages and reticulum cells. J Reticuloendothel Soc 1980; 28: 585-599.
12. Beelen RHJ, Fluitsma DM, Hoefsmit ECM. Peroxidatic activity of mononuclear phagocytes developing in omentum milky spots. J Reticuloendothel Soc 1980; 28: 601-609.
13. Shimotsuma M, Takahashi T, Hagiwara A. Staining of macrophages in rat omental milky spots using Leucomethylene blue (Neurostain). J New Remedi Clinic 1988; 37: 1217-1222.
14. Aronson M, Shahar A. Formation of histiocytes by the omentum in vivo. Exp Cell Res 1965; 38: 133-143.
15. Zweifach BW, Lipovsky HH. Quantitative studies of macrocirculatory structure and function. III. Microvascular hemodynamics of cat mesentery and rabbit omentum. Circ Res 1977; 41: 380-390.
16. Trebichavsky I, Holub M, Jaroskova L, Mandel L, Kovaru F. Ontogeny of lymphatic structures in the pig omentum. Cell Tissue Res 1981; 215: 437-442.
17. Brandt A, Schnorr B. The vascular supply of the greater omentum in sheep and goat. Z Mikrosk-Anat Forsch 1983; 97: 427-440.
18. Seifert E. Zur Biologie des menschlichen grosses Netzes. Arch Clin Chir 1921; 116: 510-517.
19. Shimotsuma M, Shields JW, Simpson-Morgan MW, Sakuyama A, Shirasu M, Hagiwara A et al. Morpho-physiological function and role of omental milky spots as omentum-associated lymphoid tissue (OALT) in the peritoneal cavity. Lymphology 1993; 26: 90-101.
20. Dux K, Janik P, Szaniawska B. Kinetics of proliferation, cell differentiation, and IgM secretion in the omental lymphoid organ of B10/Sn mice following intraperitoneal immunization with sheep erythrocytes. Cell Immunol 1977; 32: 97-109.
21. Dux K, Rouse RV, Kyewski B. Composition of the lymphoid cell populations from omental milky spots during the immune response in C57BL/Ka mice. Eur J Immunol 1986; 16: 1029-1032.
22. Beelen RHJ. The greater omentum: physiology and immunological concepts. Neth J Surg 1991; 43: 145-149.
23. Shimotsuma M, Takahashi T, Kawata M, Dux K. Cellular subsets of the milky spots in the human great omentum. Cell Tissue Res 1991; 264: 599-601.
24. Heel KA, Hall JC. Peritoneal defences and peritoneum-associated lymphoid tissue. Br J Surg 1996; 83: 1031-1036.
25. van Vugt E, Van Rijthoven EA, Kamperdijk EW, Beelen RH. Omental milky spots in the local immune response in the peritoneal cavity of rats. Anat Rec 1996; 244: 235-245.
26. Cui L, Johkura K, Liang Y, Teng R, Ogiwara N, Okouchi Y et al. Biodefence function of omental milky spots through cell adhesion molecules and leucocyte proliferation. Cell Tissue Res 2002; 310: 321-330.
27. Tanaka H. Comparative cytologic studies by means of an electron microscope on monocytes, subcutaneous histiocytes, reticulum cells in the lymph nodes and peritoneal macrophages. Annu Rep Inst Virus Res Kyoto Univ 1958; 1: 87-149.
28. Takemori N, Ito T. Response of omental milky spots to colloidal saccharated ferric oxide in the mouse: light and electron microscopic study. Hokkaido Igaku Zasshi 1981; 56: 199-216.
29. Cranshaw ML, Leak LV. Milky spots of the omentum: a source of peritoneal cells in the normal and stimulated animal. Arch Histol Cytol 1990; 53 (Suppl): 165-177.
30. Wijffels JF, Hendrickx RJ, Steenbergen JJ, Eestermans IL, Beelen RH. Milky spots in the mouse omentum may play an important role in the origin of peritoneal macrophages. Res Immunol 1992; 143: 401-409.
31. Takemori N, Hirai K, Onodera R, Saito N, Namiki M. Light and electrone microscope study of splenoportal milky spots in New Zealand black mice: comparison between splenoportal milky spots and aberrant spleens. J Anat 1995; 186: 287-299.
32. Dux K. Proliferative activity of macrophages in the greater omentum of the mouse in relation to the early postnatal development of the vascular structures. J Leukoc Biol 1986: 40: 445-448.
33. Shimotsuma M, Kawata M, Hagiwara A, Takahashi T. Milky spots in the human greater omentum. Macroscopic and histological identification. Acta Anat 1989; 136: 211-216.
34. Lenzi HL, Oliveira DN, Pelajo-Machado M, Borojevic R, Lenzi JA. Coelom-associated lymphomyeloid tissue (milky spots): site of lymphoid and myelomonocytic cell generation. Braz J Med Biol Res 1996; 29: 19-24.
35. Webb RL. Peritoneal reactions in the white rat, with especial reference to the mast cells. Am J Anat 1931; 49: 283-334.
36. Murata J. Studies on macrophages in the peritoneal cavity. Report II. The origin of macrophages in the peritoneal cavity. Int J Hematol 1955; 18: 49-62.
37. Bartoszewicz W, Dux K. Electron-microscopic examinations of omental milk spots of normal mice. Nowotwory 1968; 18: 225-235.
38. Hirai K, Takemori N, Onodera R, Watanabe S, Saito N, Namiki M. Extramedullary hematopoietic ability of mouse omentum: electron microscopic observation. J Clin Electron Microsc 1992; 25: 421-422.
39. Hirai K, Takemori N, Namiki M. Erythropoiesis in mouse omental milky spots induced by erythropoietin: light and electronmicroscopic study. Int J Exp Pathol 1994; 75: 375-383.
40. Dobbie JW. Pathogenesis of peritoneal fibrosingsyndromes (sclerosing peritonitis) in peritoneal dialysis. Perit Dial Int 1992; 12: 14-27.
41. Dobbie JW, Anderson JD, Hind C. Long-term effects of peritoneal dialysis on peritoneal morpholohy. Perit Dial Int 1994; 14 (Suppl 3): S16-S20.
42. Garosi G, Di Paolo N. Recent advances in peritoneal morphology: the milky spots in peritoneal dialysis. Adv Perit Dial 2001; 17: 25-28.
43. Garosi G, Di Paolo N. The rabbit model in evaluating the biocompatibility in peritoneal dialysis. Nephrol Dial Transplant 2001; 16: 664-665.
44. Hekking LHP, Zareie M, Driesprong BAJ, Faict D, Welten AGA, De Greeuw I, et al. Better preservation of peritoneal morphologic features and defense in rats after long-term exposure to a bicarbonate/lactate-buffered solution. J Am Soc Nephrol 2001; 12: 2775-2786.
45. Zareie M, Hekking LH, Driesprong BA, ter Wee PM, Beelen RH, van den Born J. Accumulation of omental mast cells during peritoneal dialysis. Perit Dial Int 2001; 21 (Suppl 3): S373-S376.
46. Zareie M, Hekking LHP, Welten AGA, Driesprong BAJ, Schadee-Eestermans IL, Faict D et al. Contribution of lactate buffer, glucose and glucose degradation products to peritoneal injury in vivo. Nephrol Dial Transplant 2003; 18: 2629-2637.
47. Muscatello G. Über den Bau und das Aufsaugungsvermögen des Peritonaeum. Anatomische und experimentelle Untersuchungen. Virchows Arch Pathol Anat 1905;142: 327-357.
48. De Renzi E, Boeri G. Das Netz als Schutzorgan. Berl Klin Wochenschr 1903; 40: 773-775.
49. Fisher E. Das Lymphgefässystem des grossen Netzes. Langenbecks Arch Klin Chir 1934; 180: 68-70.
50. Fisher E. Über den Ursprung der Lymphgefaesse und den Begriff der sog. Lymphgefässe Perivasculären. Zbl Chir 1934; 234: 706-715.
51. Milian G. La mobilite defensive de l'epiploon. Gaz Hop (Paris) 1899; 72: 681-686.
52. Seifert E. Zur Funktion des grossen Netzes. Eine experimentelle Studie, zugleich ein Beitrag zur Kenntnis vom Schicksal fernkoerniger Stoffe in der Peritonealhoehle. Brun's Beitr Klin Chir 1920; 119: 249-287.
53. Carr I. The fine structure of the cells of the mouse peritoneum. Z Zellforsch 1967; 80: 543-555.
54. Borisov AV. Lymphatic capillaries and blood vessels of milky spots in the human greater omentum. Fed Proc 1964; 23: 150-154.
55. Lang J. Über die Gefässe und die Zellen der Milchflecken. Z Zellforsch 1965; 66: 1-27.
56. Intaglietta M, Zweifach BW. Geometrical model of the microvasculature of rabbit omentum from in vivo measurements. Circ Res 1971; 28: 593-600.
57. Intaglietta M, Zweifach BW. Microcirculatory basis of fluid exchange. Adv Biol Med Phys 1974; 15: 111-159.
58. Dux K. Anatomy of the greater omentum and lesser omentum in the mouse with some physiological implications. In: Goldsmith H, editor. The Omentum. Research and Clinical Applications. Springer-Verlag, Berlin, 1990; 19-43.
59. Takemori N. Morphological studies of the omental milk spots in the mouse: Light and electron microscopy. Hokkaido Igaku Zasshi 1979; 54: 265-283.
60. Kanazawa K. Exchanges through the pleura. Cells and particles. In: Chretien J et al, editors. The Pleura in Health and Disease. Dekker, New York, 1985; 195-231.
61. Marchand F. Über Clasmatocyten, Mastzellen und Phagocyten des Netzes. Verh Dtsch Path Ges 1901; 4: 121-131.
62. Takemori N. Histogenesis of the omental milky spot of the mouse. Hokkaido Igaku Zasshi 1980; 55: 409-418.
63. Casparis HR. Lymphatics of the omentum. Anat Rec 1918; 15: 93-99.
64. Simer PH. On the morphology of the omentum, with especial reference to its lymphatics. Am J Anat 1934; 54: 203-228.
65. Simer PH. Omental lymphatics in man. Anat Rec 1935; 63: 253-262.
66. Webb RL, Simer PH. The relation of lymph vessels to omental milky spots. Anat Rec 1942; 83: 437-447.
67. Zweifach BW, Schmid-Schoenbein GW. Pressure and flow reactions in the lymphatic system. In: Johnston MG, editor. Experimental Biology of the Lymphatic Circulation. Elsevier, Amsterdam, 1985; 46-79.
68. Kanazawa K, Roe FJC, Yamamoto T. Milky spots (taches laiteuses) as structures which trap asbestos in mesothelial layers and their significance in the pathogenesis of mesothelial neoplasia. Int J Cancer 1979; 23: 858-865.
69. Maximow A. Über des Mesothel (Deckzellen der seroesen Haute) und die Zellen der serösen Exsudate. Untersuchungen an entzündeten Gewebe und an Gewebskulturen. Arch Exp Zellforsch 1927; 4: 1-42.
70. Felix MD. Observation on the surface cells of the mouse omentum as studied with the phasecontrast and electron microscopes. J Nat Cancer Inst 1961; 27: 713-745.
71. Orenstein JM, Shelton E. Surface topography of leucocytes in situ: Cells of mouse peritoneal milky spots. Exp Mol Pathol 1976; 24: 415-423.
72. Mironov VA, Gusev SA, Baradi AF. Mesothelial stomata overlying omental milky spots: scanning electron microscopic study. Cell Tissue Res 1979; 201: 327-330.
73. Shimotsuma M, Hagiwara A, Takahashi T, Kawata M, Shields JW. Surface structure and cell zonation in human omental milky spots. Lymphology 1990; 23: 207-208.
74. Michailova KN. Postinflammatory changes of the diaphragmatic stomata. Ann Anat 2001; 183; 309-317.
75. Michailova K, Wassilev W, Wedel T. Scanning and transmission electron microscopic study of visceral and parietal peritoneal regions in the rat. Anat Anz 1999; 181: 253-260.
76. Koten JW, Otter W. Are omental milky spots an intestinal thymus? Lancet 1991; 338: 1189-1190.
77. Yildirim A, Akkus M, Nergiz Y, Yuruker S. Immunohistochemical analysis of CD31, CD36, and CD44 antigens in human omentum. Saudi Med J 2004; 25: 308-312.
78. Young LC, Watkins S, Wilhelm, DL. The mast cell: distribution and maturation in the peritoneal cavity of the adult rat. Pathology 1975; 7: 307-318.
79. Young LC, Watkins S, Wilhelm DL. The mast cell: II. Distribution and maturation in the peritoneal cavity of the adult rat. Pathology 1977; 9: 221-232.
80. Beelen RHJ, Eestermans IL, Dopp EA, Dijkstra CD. Immunological characteristics of milky spots in the omentum of rats. Adv Exp Med Biol 1988; 237: 745-750.
81. Krist LF, Eestermans IL, Steenbergen JJ, Hoefsmit EC, Cuesta MA, Meyer S et al. Cellular composition of milky spots in the human greater omentum: an immunochemical and ultrastructural study. Anat Rec 1995; 241: 163-174.
82. Hagiwara A, Takahashi T. A new drug-delivery-system of anticancer agents: Activating carbon particles adsorbing anticancer agents. In Vivo 1987; 1: 241-252.
83. Shimotsuma M, Simpson-Morgan MW. Omental milky spots. Lancet 1991; 338: 1596.
84. Shimotsuma M, Shirasu M, Hagiwara A, Takahashi T, Shields JW. Omental milky spots and the local immune response. Lancet 1992; 339: 1232.
85. Imai Y, Kasajima T, Matsuda M. Electron microscopic study on the peritoneal macrophage and milky spot in omentum. Recent Adv RES Res 1971; 11: 54-84.
86. Watanabe K, Masubucchi S, Kageyama K. Ultrastructural localization of peroxidase in mononuclear phagocytes from the peritoneal cavity, blood, bone marrow and omentum with a special reference to the origin of peritoneal macrophages. Recent Adv RES Res 1973; 11: 120-144.
87. Daems WT, de Bakker JM. Do resident macrophages proliferate? Immunobiology 1982; 161: 204-211.
88. Zhu H, Naito M, Umezu H, Moriyama H, Takatsuka H, Takahashi K et al. Macrophage differentiation and expression of macrophage colony-stimulating factor in murine milky spots and omentum after macrophage elimination. J Leukoc Biol 1997; 61: 436-444.
89. Portis B. Role of omentum of rabbits, dogs and guinea-pigs in antibody production. J Infect Dis 1924; 34: 159-185.
90. Dux K, Rouse RV, Kyewski B. Composition of the lymphoid cell populations from omental milky spots during the immune response in C57BL/Ka mice. Eur J Immunol 1986; 16: 1029-1032.
91. Hajdu I, Holub M, Trebichavsky I. The sequence of appearance of antibodies in mouse omentum plasma cells. Exp Cell Res 1972; 75: 219-230.
92. Mandache E, Moldoveanu E, Negoescu A. Lymphatic follicle-like structures in the stimulated omental milky spots. Morphol Embryol 1987; 33: 285-299.
93. Raveche ES, Laskin CA, Rubin C, Tjio JH, Steinberg AD. Comparison of stem-cell recovery in autoimmune and normal strains. Cell Immunol 1983; 79: 56-67.
94. Pond CM. Physiological specialization of adipose tissue. Prog Lipid Res 1999; 38: 225-248.
95. Pond CM. Adipose tissue: quartermaster to the lymph node garrisons. Biologist (London) 2000; 47: 147-150.
96. Pond CM. Adipose tissue, the anatomists' Cinderella, goes to the ball at last, and meets some influentialpartners. Postgrad Med J 2000; 76: 671-673.
97. Pond CM, Mattacks CA. Interactions between adipose tissue around lymph nodes and lymphoid cells in vitro. J Lipid Res 1995; 36: 2219-2231.
98. Pond CM. Paracrine interactions of mammalian adipose tissue. J Exp Zoolog Part A Comp Exp Biol 2003; 295: 99-110.
99. Pond CM. Paracrine relationships between adipose and lymphoid tissues: implications for the mechanism of HIV-associated adipose redistribution syndrome. Trends Immunol 2003; 24: 13-18.
100. Mattacks CA, Pond CM. Interactions of noradrenalin and tumour necrosis factor alpha, interleukin 4 and interleukin 6 in the control of lipolysis from adipocytes around lymph nodes. Cytokine 1999; 11: 334-346.
101. Edvinsson L, Hakanson R, Steen S, Sundler F, Uddman R, Wahlesteadt C. Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide. Regul Peptides 1985; 12: 67-79.
102. Krist LF, Eestermans IL, Steinbusch HW, Cuesta MA, Meyer S, Beelen RHJ. An ultrastructural study of dopamine-immunoreactive nerve fibresinmilkyspotsofthe human greater omentum. Neurosci Lett 1994; 168: 143-146.
103. Amenta F, Ricchi A, Tayebati SK, Zaccheo D. The peripheral dopaminergic system: morphological analysis, functional and clinical implications. Ital J Anat Embryol 2002; 107: 145-167.
104. Takemori N. Milky spots on the parietal peritoneum over the pancreas in the mouse. Hokkaido Igaku Zasshi 1979; 54: 379-385.
105. Fujiwara H, Kubota T, Amaike H, Inada S, Takashima K, Atsuji K, et al. Functional analysis of peritoneal lymphoid tissues by GFP expression in mice - possible application for targeting gene therapy against peritoneal dissemination. Gan To Kagaku Ryoho 2002; 29: 2322-2324.
106. Kampmeier OF. Concerning certain mesothelial thickenings and vascular plexuses of the mediastinal pleura, associated with histiocyte and fat-cell production, in the human newborn. Anat Rec 1928; 39: 201-208.
107. Pereira AS, Aguas AP, Oliveira MJ, Cabral JM, Grande NR. Experimental modulation of the reactivity of pleural milky spots (Kampmeier's foci) by Freund's adjuvants, betamethasone and mycobacterial infection. J Anat 1994; 185: 471-479.
108. Mixter RL. On macrophagal foci ("milky spots") in the pleura of different mammals, including man. Am J Anat 1941; 69: 159-186.
109. Inoue N, Otsuki Y. Lymphocyte subpopulations in mediastinal milky spots of mice: light and elec-tron-microscopic immunohistochemical observations. Arch Histol Cytol 1992; 55: 89-96.
110. Pereira AS, Grande NR. Particle clearance from the canine pleural space into thoracic lymph nodes: an experimental study. Lymphology 1992; 25: 120-128.
111. Boutin C, Dumortier P, Rey F, Viallat JR, De Vuyst P. Black spots concentrate oncogenic asbestos fibersintheparietal pleura. Thoracoscopic and mineralogic study. Am J Respir Crit Care Med 1996; 153: 444-449.
112. Aharinejad S, Franz P, Firbas W. The milky spots on the chest wall in newborns. Acta Anat 1990; 138: 341-347.
113. Li YY, Li JC. Ultrastructure and three-dimensional study of the lymphatic stomata in the costal pleura of the rabbit. Microsc Res Tech 2003; 62: 240-246.
114. Nakatani T, Shinohara H, Fukuo Y, Morisawa S, Matsuda T. Pericardium of rodents: pores connect the pericardial and pleural cavities. Anat Rec 1988; 220: 132-137.
115. Fukuo Y, Nakatani T, Shinohara H, Matsuda T. The mouse pericardium: it allows passage of particulate matter from the pleural to the pericardial cavity. Anat Rec 1988; 222: 1-5.
116. Takada K, Otsuki Y, Magari S. Lymphatics and pre-lymphatics of the rabbit pericardium and epicardium with special emphasis on particulate absorption and milky spot-like structures. Lympology 1991; 24: 116-124.
117. Maximow A. Bindegewebe und blutbildende Gewebe. In: von Moellendorf, editor. Handbuch der mikroskopishen Anatomie des Menschen, Vol II. Springer, Berlin, 1924; 289-309.
118. Takemori N, Ito T. Sex difference in the mouse milk spots, with special reference to its development and formation. Hokkaido Igaku Zasshi 1979; 54: 285-289.
119. Krist LF, Koenen H, Calame W, van der Harten JJ, van der Linden JC, Eestermans IL et al. Ontogeny of milky spots in the human greater omentum: an immunochemical study. Anat Rec 1997; 249: 399-404.
120. Shimotsuma M, Simpson-Morgan MW, Takahashi T, Hagiwara A. Ontogeny of milky spots in the fetal lamb omentum. Arch Histol Cytol 1994; 57: 291-299.
121. Kremli SM, Mamontov SG. Morphological features of milky spots of the rat omentum in inflammation. Biull Eksp Biol Med 1990; 109: 616-619.
122. Shimotsuma M, Simpson-Morgan MW, Takahashi T, Hagiwara A. Activation of omental milky spot macrophages by intraperitoneal administration of a streptococcal preparation, OK-432. Cancer Res 1992; 52: 5400-5402.
123. Fukatsu K, Saito H, Han I, Yasuhara H, Lin MT, Inoue T et al. The greater omentum is the primary site of neutrophil exudation in peritonitis. J Am Coll Surg 1996; 183: 450-456.
124. Broche F, Tellado JM. Defense mechanisms of the peritoneal cavity. Curr Opin Crit Care 2001; 7: 105-116.
125. Marchand F. Aeltere und neuere Beobachtungen zur Histologie des Omentum. Haematologica 1924; 5: 304-348.
126. Fasske E. Über die Criokaryocyten im aktiven Mesenchym. Virchows Arch Pathol Anat 1962; 335: 63-71.
127. Fritsch H. Zur Frage der ringkernigen Zellen in den "Taches laiteuses" des Mesenterium der Maus. Z Zellforsch 1963; 59: 224-238.
128. Fritsch H, Ule G. Zur Feinstruktur der Cricokaryozyten. Z Zellforsch 1963; 60: 392-398.
129. Baillif RN. Reaction of the rat omentum to injection of particulate matter. Soc Exp Biol Med 1941; 47: 409-414.
130. Seifert E. Studien am Omentum majus des Menschen. Langebecks Arch Klin Chir 1923; 123: 608-683.
131. Cappell DF. Intravital and supravital staining. IV. The cellular reactions following mild irritation of the peritoneum in normal and vitally stained animals, with special reference to the origin and nature of the mononuclear cells. J Path Bact 1930; 33: 429-452.
132. Weinberg DF, Baldo-Correa E, Lenzi HL, Borojevic R. Schistosoma mansoni: peritoneal plasmacytogenesis and polyploid transformation of mesenteric milky spots in infected mice. Exp Parasitol 1992; 74: 408-416.
133. van Vugt E, Verdaasdonk MA, Beelen RH, Kamperdijk EW. Induction of an increased number of dendritic cells in the peritoneal cavity of rats by intraperitoneal administration of Bacillus Calmette-Guerin. Immunobiology 1992; 186: 230-240.
134. Doherty NS, Griffiths RJ, Hakkinen JP, Scampoli DN, Milici AJ. Post-capillary venules in the "milky spots" of the greater omentum are the major site of plasma protein and leukocyte extravasation in rodent models of peritonitis. Inflamm Res 1995; 44: 169-177.
135. Pinho MF, Hurtado SP, El-Cheikh MC, Rossi MI, Dutra HS, Borojevic R. Myelopoiesis in the omentum of normal mice and during abdominal inflammatory processes. Cell Tissue Res 2002; 308: 87-96.
136. Haslett C. Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am J Respir Crit Care Med 1999; 160: S5-S11.
137. Bellingan GJ, Caldwell H, Howie SE, Dransfield I, Haslett C. In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes. J Immunol 1996; 157: 2577-2585.
138. Bellingan GJ, Xu P, Cooksley H, Cauldwell H, Shock A, Bottoms S et al. Adhesion molecule-dependent machanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J Exp Med 2002; 196: 1515-1521.
139. Gotloib L, Shostak A, Vajsbrot V, Kuschnier R. The cytochemical profile of visceral mesothelium under the influence of lactated-hyperosmolar peritoneal dialysis solutions. Nephron 1995; 69: 466-471.
140. Krediet RT, Zweers MM, van der Wal AC, Struijk DG. Neoangiogenesis in the peritoneal membrane. Perit Dial Int 2000; 20 (Suppl 2): S19-S25.
141. Yanez-Mo M, Lara-Pezzi E, Selgas R, Ramirez-Hueska M, Dominguez-Jimenez C, Jimenez-Heffernan JA. Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Engl J Med 2003; 348: 403-413.
142. Visser CE, Brouwer-Steenbergen JJE, Betjes MGH, Meijer S, Arisz L, Hoefsmit ECM et al. Interleukin-8 production by human mesothelial cells after direct stimulation with staphilococci. Infect Immun 1995; 63: 4206-4209.
143. Visser CE, Brouwer-Steenbergen JJE, Schadee-Eestermans IL, Meijer S, Krediet RT, Beelen RHJ. Ingestion of Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli by human peritoneal mesothelial cells. Infect Immun 1996; 64: 3425-3428.
144. Coles GA, Lewis SL, Williams JD. Host defence and effects of solutions on peritoneal cells. In: Gokal R, Nolph KD, editors. Textbook of Peritoneal Dialysis. Kluwer Academic Publishers, Dordrecht, The Netherlands, 1994; 503-528.
145. Topley N, Mackenzie RK, Williams JD. Macrophages and mesothelial cells in bacterial peritonitis. Immunobiology 1996; 195: 563-573.
146. Visser CE, Tekstra J, Brouwer-Steenbergen JJ, Tuk CW, Boorsma DM, Sampat-Sardjoepersad SC et al. Chemokines produced by mesothelial cells: huGRO-alpha, IP-10, MCP-1 and RANTES. Clin Exp Immunol 1998; 112: 270-275.
147. Mercer-Jones MA, Shrotri MS, Heinzelmann M, Peyton JC, Cheadle WG. Regulation of early peritoneal neutrophil migration by macrophage inflammatory proteins-2 and mast cells in experimental peritonitis. J Leukoc Biol 1999; 65: 249-55.
148. Skurzak H, Dux K. Immunofluorescent studies of milky spots of rats inoculated with Ehrlich ascites tumor cells. Nowotwory 1971; 21: 103-106.
149. Green J, Williams AE. The relationship between inflammatory responses and WBP1 tumor cell attachement to the rat omentum. Eur J Cancer 1978; 14: 1153-1155.
150. Koerten HK. The Formation of Asbestos Bodies and Similar Structures by Macrophage Exocytotic Activity. PhD Thesis. Drukkerij NEFLI B. V., Haarlem, The Netherlands, 1989.
151. Dodson RF, O'Sullivan MF, Huang J, Holliday DB, Hammar SP. Asbestos in extrapulmonary sites: omentum and mesentery. Chest 2000; 117: 486-493.
152. Mutsaers SE. The mesothelial cell. Int J Biochem Cell Biol 2004; 36: 9-16.
153. Tobai S. Electronmicroscopic studies on the invasion and intravasation of Yoshida sarcoma cells in the omentum. Fukushima I Med Sci 1981; 31: 31-46.
154. Shimotsuma M, Itoh M, Sasabe T. Role of omental milky spots in peritoneal metastases of carcinoma. Oncologia 1991; 24: 80-85.
155. Lawrence RJ, Loizidou, M, Cooper AJ, Alexander P, Taylor I. Importance of the omentum in the development of intra-abdominal metastases. Br J Surg 1991; 78: 117-119.
156. Murphy P, Alexander P, Senior PV, Fleming J, Kirkham N, Taylor I. Mechansisms of organ selective tumour growth by blood-borne cancer cells. Br J Cancer 1988; 57: 19-31.
157. Goldsmith HS, Griffin AL, Kupfermann A, Catsimpoolas N. Lipid angiogenic factor from the omentum. JAMA 1984; 252: 2034-2036.
158. Goldsmith HS, McIntosh T, Vezina RM, Colton T. Vasoactive neurochemical identified in omentum: A preliminary report. Br J Neurosurg 1987; 1: 359-364.
159. Hagiwara A, Takajashi T, Sawai K, Taniguchi H, Shimotsuma M, Okano S et al. Milky spots as the implantation site for malignant cells in peritoneal dissemination in mice. Cancer Res 1993; 53: 687-692.
160. Tsujimoto H, Takahashi T, Hagiwara A, Shimotsuma M, Sakakura C, Osaki K, et al. Site-specific implantation in the milky spots of malignant cells in peritoneal dissemination: immunohistochemical observation in mice inoculated intraperitoneally with bromodeoxyuridine-labelled cells. Br J Cancer 1995; 71: 468-472.
161. Tsujimoto H, Hagiwara A, Shimotsuma M, Sakakura C, Osaki K, Sasaki S, et al. Role of milky spots as selective implantation sites for malignant cells in peritoneal dissemination in mice. J Cancer Res Clin Oncol 1996; 122: 590-595.
162. Krist LF, Kerremans M, Broekhuis-Fluitsma DM, Eestermans IL, Meyer S, Beelen RHJ. Milky spots in the greater omentum are predominant sites of local tumour cell proliferation and accumulation in the peritoneal cavity. Cancer Immunol Immunother 1998; 47: 205-212.
163. Sampson JA. The origin and significance of newly formed lymph vessels in carcinomatous peritoneal implants. Am J Pathol 1936; 12: 432-467.
164. Shipley PG, Cunningham RS. Studies on absorption from serous cavities. Am J Phys Med 1916; 40: 75-81.
165. Cunningham RS. Studies on absorption from serous cavities. Am J Phys Med 1920; 21: 488-494.
166. Wilkie DPD. Some functions and surgical uses of the omentum. Br Med J 1911; 2: 103-1106.
167. Birbeck MSC, Wheatley DN. An electron microscopic study of the invasion of ascites tumor cells into the abdominal wall. Cancer Res 1965; 25: 490-497.
168. Terranova VP, Hujanen ES, Martin GR. Basement membrane and the invasive activity of metastatic tumor cells. J Natl Cancer Inst 1986; 77: 311-316.
169. Lopes Cardozo AM, Gupta A, Koppe MJ, Meijer S, van Leeuwen PA et al. Metastatic pattern of CC531 colon carcinoma cells in the abdominal cavity: an experimental model of peritoneal carcinomatosis in rats. Eur J Surg Oncol 2001; 27: 359-363.
170. Yamamura S, Onda M, Uchida E. Two types of peritoneal dissemination of pancreatic cancer cells in a hamster model. Nippon Ika Daigaku Zasshi 1999; 66: 253-261.
171. Bast RC, Berek JS, Obrist R. Intraperitoneal immunotherapy of human ovarian carcinoma with Corynebacterium parvum. Cancer Res 1983; 43: 1395-1401.
172. Torisu M, Katano M, Kimura Y, Itoh H, Takesue M. New approach to management of malignant ascites with a streptococcal preparation, OK-432. I. Improvement of host immunity and prolongation of survival. Surgery 1983; 93: 357-364.
173. Eggermont AMM, Sugarbaker PH. Immunogenecity of the tumor determines the outcome of immunotherapy with interleukin-2, ABPP, and cyclophosphamide of micro-and macrometastatic intraperitoneal tumor. Cancer Detect Prev 1990; 14: 483-490.
174. Eggermont AMM, Sugarbaker PH. Intraperitoneal chemotherapy and immunotherapy. Onkologie 1991; 14: 123-136.
175. Hwu P, Freedman RS. The immunotherapy of patients with ovarian cancer. J Immunother 2002; 25: 189-201.
176. Shimotsuma M, Shirasu M, Hagiwara A, Takahashi T. Role of omentum-associated lymphoid tissue in the progression of peritoneal carcinomatosis. Cancer Treat Res 1996; 82: 147-154.
177. Melichar B, Freedman RS. Immunology of the peritoneal cavity: relevance for host-tumor relation. Int J Gynecol Cancer 2002; 12: 3-17.
178. Rasmussen LT, Seljelid R. Novel immunomodulators with pronounced in vivo effects caused by stimulation of cytokine release. J Cell Biochem 1991; 46: 60-68.
179. Dullens HF, Rademakers LH, Doffemont M, van Veen PT, Bulder R, Den Otter W. Involvement of the omental lymphoid organ in the induction of peritoneal immunity against tumor cells. Invasion Metastasis 1993; 13: 267-276.
180. Koenen HJ, Smit MJ, Simmelink MM, Schuurman B, Beelen RHJ, Meijer S. Effect of intraperitoneal administration of granulocyte/macrophage-colony- stimulating factor in rats on omental milky-spot composition and tumoricidal activity in vivo and in vitro. Cancer Immunol Immunother 1996; 42: 310-316.
181. Odaka M, Sterman DH, Wiewrodt R, Zhang Y, Kiefer M, Amin KM, et al. Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon -beta gene therapy is attributable to induction of systemic immunity. Cancer Res 2001; 61: 6201-6212.
182. Odaka M, Wiewrodt R, DeLong P, Tanaka T, Zhang Y, Kaiser L, et al. Analysis of the immunologic response generated by Ad.IFN-beta during successful intraperitoneal tumor gene therapy. Mol Ther 2002; 6: 210-218.