Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration

Journal of Mass Spectrometry

Volumn 41, Issue 11, 2006, Pages 1430-1441

  Tong, Wei ^a   Chowdhury, Swapan K ^a   Su, Ai Duen ^a   Feng, Wenqing ^a   Ghosal, Anima ^a   Alton, Kevin B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Lonafarnib; Metabolite identification; Stable isotope; TOF; Unstable metabolite

Indexed keywords

DEHYDROGENATION; DRUG PRODUCTS; ION SOURCES; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE;

LONAFARNIB; STABLE ISOTOPE INCORPORATION;

METABOLITES;

ALKALI; COMPLEMENTARY DNA; CYTOCHROME P450 3A4; DRUG METABOLITE; LONAFARNIB; POTASSIUM ION; SODIUM ION;

ACCURACY; ARTICLE; DRUG IDENTIFICATION; DRUG INDUSTRY; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCUBATION TIME; ION TRAP MASS SPECTROMETRY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON TRANSPORT; QUADRUPOLE MASS SPECTROMETRY; TEMPERATURE MEASUREMENT; TIME OF FLIGHT MASS SPECTROMETRY;

CARBON ISOTOPES; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DRUG STABILITY; HUMANS; IONS; ISOTOPE LABELING; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PIPERIDINES; PYRIDINES; TEMPERATURE;

EID: 33845306266     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1114     Document Type: Article

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