Spinal delivery of p38: TNF-alpha inhibitors [11]

PLoS Medicine

Volumn 3, Issue 11, 2006, Pages 2168-

  Tobinick, Edward ^a  

^a Institute for Neurological Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETANERCEPT; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; ENZYME ACTIVATION; HUMAN; INFLAMMATION; LETTER; NEUROPATHIC PAIN; PAIN; SIGNAL TRANSDUCTION; ANIMAL; ARTHRITIS; DRUG ANTAGONISM; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; NOTE; PATHOPHYSIOLOGY;

ANIMALS; ARTHRITIS; INJECTIONS, SPINAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33845295416     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.0030511     Document Type: Letter

References (10)

1. Boyle DL, Jones TL, Hammaker D, Svensson CI, Rosengren S, et al. (2006) Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med 3: e338. doi:10.1371/journal.pmed.0030338
2. Schafers M, Svensson CI, Sommer C, Sorkin LS (2003) Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci 23: 2517-2521.
3. Culbert AA, Skaper SD, Howlett DR, Evans NA, Facci L, et al. (2006) MAPK-activated protein kinase 2 deficiency in microglia inhibits proinflammatory mediator release and resultant neurotoxicity: Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease. J Biol Chem 281: 23658-23667.
4. Takeuchi H, Jin S, Wang J, Zhang G, Kawanokuchi J, et al. (2006) Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J Biol Chem 281: 21362-21368.
5. Stellwagen D, Malenka RC (2006) Synaptic scaling mediated by glial TNFalpha. Nature 440: 1054-1059.
6. Sommer C, Schafers M, Marziniak M, Toyka KV (2001) Etanercept reduces hyperalgesia in experimental painful neuropathy. J Peripher Nerv Syst 6: 67-72.
7. Tobinick E, Gross H, Weinberger A, Cohen H (2006) TNF-alpha modulation for treatment of Alzheimer's disease: A 6-month pilot study. MedGenMed 8: 25.
8. Tobinick EL, Britschgi-Davoodifar S (2003) Perispinal TNF-alpha inhibition for discogenic pain. Swiss Med Wkly 133: 170-177.
9. Tobinick E (2006) The cerebrospinal venous system: Anatomy, physiology, and clinical implications. MedGenMed 8: 53.
10. Byrod G, Rydevik B, Johansson BR, Olmarker K (2000) Transport of epidurally applied horseradish peroxidase to the endoneurial space of dorsal root ganglia: A light and electron microscopic study. J Peripher Nerv Syst 5: 218-226.