Inhibition kinetics of the gastric H,K-ATPase by K-competitive inhibitor SCH28080 as a tool for investigating the luminal ion pathway

Annals of the New York Academy of Sciences

Volumn 986, Issue , 2003, Pages 111-115

  Vagin, Olga ^a,b   Munson, Keith ^a   Denevich, Svetlana ^a   Sachs, George ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

H,K ATPase; Inhibition kinetics; SCH28080

Indexed keywords

8 BENZYLOXY 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 ACETONITRILE; AMINO ACID; ASPARTIC ACID; GLUTAMIC ACID; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; ISOLEUCINE; LEUCINE; LYSINE; OUABAIN; POTASSIUM ION; PROLINE; THREONINE; TYROSINE;

BINDING AFFINITY; BINDING COMPETITION; CONFERENCE PAPER; DRUG SENSITIVITY; ENZYME BINDING; ENZYME STRUCTURE; INHIBITION KINETICS; ION TRANSPORT; MUTATIONAL ANALYSIS; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; STOMACH;

STROPHANTHUS GRATUS;

EID: 0038579549     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb07147.x     Document Type: Conference Paper

References (5)

1. MUNSON, K.B., N. LAMBRECHT & G. SACHS. 2000. Effects of mutations in M4 of the gastric H+,K+-ATPase on inhibition kinetics of SCH28080. Biochemistry 39: 2997-3004.
2. ASANO, S., S. MATSUDA, S. HOSHINA, et al. 1999. Chimeric gastric H+,K+-ATPase inhibitable with both ouabain and SCH 28080. J. Biol. Chem. 274: 6848-6854.
3. FARLEY, R.A., S. SCHREIBER, S.G. WANG & G. SCHEINER-BOBIS. 2001. A hybrid between Na+,K+-ATPase and H+,K+-ATPase is sensitive to palytoxin, ouabain, and SCH 28080. J. Biol. Chem. 276: 2608-2615.
4. MUNSON, K.B., C. GUTIERREZ, V.N. BALAJI, et al. 1991. Identification of an extracytoplasmic region of H+,K(+)-ATPase labeled by a K(+)-competitive photoaffinity inhibitor. J. Biol. Chem. 266: 18976-18988.
5. HERSEY, S.J., L. STEINER, J. MENDLEIN, et al. 1988. SCH28080 prevents omeprazole inhibition of the gastric H+/K+-ATPase. Biochim. Biophys. Acta 956: 49-57.