The human basonuclin 2 gene has the potential to generate nearly 90,000 mRNA isoforms encoding over 2000 different proteins

Genomics

Volumn 89, Issue 1, 2007, Pages 44-58

  Vanhoutteghem, Amandine ^a   Djian, Philippe ^a  

^a CNRS   (France)

Author keywords

Alternative splicing; Basonuclin 2; Zinc fingers

Indexed keywords

AMINO ACID; BASONUCLIN; BASONUCLIN 2; MESSENGER RNA; METHIONINE; PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CODON; CONTROLLED STUDY; EXON; GENE FUNCTION; HELA CELL; HUMAN; NUCLEOTIDE SEQUENCE; POLYADENYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROCESSING; RNA SPLICING; RNA TRANSCRIPTION; RNA TRANSLATION; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION TERMINATION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CPG ISLANDS; DNA-BINDING PROTEINS; EXONS; HELA CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; POLYADENYLATION; PROMOTER REGIONS (GENETICS); PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; SPECIES SPECIFICITY; TATA BOX; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 33845189397     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2006.07.006     Document Type: Article

References (30)

1. Romano R.-A., Li H., Tummala R., and Maul R. Identification of basonuclin2, a DNA-binding zinc-finger protein expressed in germ tissues and skin keratinocytes. Genomics 83 (2004) 821-833
2. Vanhoutteghem A., and Djian P. Basonuclin 2: an extremely conserved homolog of the zinc finger protein basonuclin. Proc. Natl. Acad. Sci. USA 101 (2004) 3468-3473
3. Tseng H., and Green H. Basonuclin: a keratinocyte protein with multiple paired zinc fingers. Proc. Natl. Acad. Sci. USA 89 (1992) 10311-10315
4. Vanhoutteghem A., and Djian P. Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions. Proc. Natl. Acad. Sci. USA 103 (2006) 12423-12428
5. Kimura K., et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome Res. 16 (2006) 55-65
6. Pugh B.F., and Tjian R. Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell 61 (1990) 1187-1197
7. Pugh B.F., and Tjian R. Transcription from a TATA-less promoter requires a multisubunit TFIID complex. Genes Dev. 5 (1991) 1933-1945
8. Smale S.T., and Kadonaga J.T. The RNA polymerase II core promoter. Annu. Rev. Biochem. 72 (2003) 449-479
9. Teumer J., Tseng H., and Green H. The human basonuclin gene. Gene 188 (1997) 1-7
10. Bird A. CpG islands as gene markers in the vertebrate nucleus. Trends Genet. 3 (1987) 342-347
11. Gardiner-Garden M., and Frommer M. CpG islands in vertebrate genomes. J. Mol. Biol. 196 (1987) 261-282
12. Bestor T.H., Gundersen G., Kolsto A.-B., and Prydz H. CpG islands in mammalian gene promoters are inherently resistant to de novo methylation. Genet. Anal. Techn. Appl. 9 (1992) 48-53
13. Britten R.J. Evidence that most human Alu sequences were inserted in a process that ceased about 30 million years ago. Proc. Natl. Acad. Sci. USA 91 (1994) 6148-6150
14. Yang Z.-h., Gallicano G.I., Yu Q.-C., and Fuchs E. An unexpected localization of basonuclin in the centrosome, mitochondria, and acrosome of developing spermatids. J. Cell Biol. 137 (1997) 657-669
15. Schmucker D., et al. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 101 (2000) 671-684
16. Ullrich B., Ushkaryov Y.A., and Südhof T. Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Neuron 14 (1995) 497-507
17. Rowen L., et al. Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity. Genomics 79 (2002) 587-597
18. Maniatis T., and Tasic B. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature 418 (2002) 236-243
19. Yeo G.W., Van Nostr E.V., Holste D., Poggio T., and Burge C.B. Identification and analysis of alternative splicing events conserved in human and mouse. Proc. Natl. Acad. Sci. USA 102 (2005) 2850-2855
20. Modrek B., and Lee C.J. Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss. Nat. Genet. 34 (2003) 177-180
21. Sorek R., Shamir R., and Ast G. How prevalent is functional alternative splicing in the human genome?. Trends Genet. 20 (2004) 68-71
22. Lewis B.P., Green R.E., and Brenner S.E. Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc. Natl. Acad. Sci. USA 100 (2003) 189-192
23. Smyth I.M., et al. Genomic anatomy of the Tyrp1 (brown) deletion complex. Proc. Natl. Acad. Sci. USA 103 (2006) 3704-3709
24. Brett D., Pospisil H., Valcarcel J., Reich J., and Bork P. Alternative splicing and genome complexity. Nat. Genet. 30 (2002) 29-30
25. Venter J.C., et al. The sequence of the human genome. Science 291 (2001) 1304-1351
26. International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature 431 (2004) 931-945
27. Rheinwald J.G., and Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 6 (1975) 331-334
28. Allen-Hoffmann B.L., and Rheinwald J.G. Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture. Proc. Natl. Acad. Sci. USA 81 (1984) 7802-7806
29. Simon M., and Green H. Participation of membrane-associated proteins in the formation of the cross-linked envelope of the keratinocyte. Cell 36 (1984) 827-834
30. Vanhoutteghem A., Londero T., Ghinea N., and Djian P. Serial cultivation of chicken keratinocytes, a composite cell type that accumulates lipids and synthesizes a novel b-keratin. Differentiation 72 (2004) 123-137