Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels

Genesis (United States)

Volumn 44, Issue 11, 2006, Pages 556-564

  Liu, Kai ^a   Hipkens, Susan ^a   Yang, Tao ^a   Abraham, Robert ^a   Zhang, Wei ^a   Chopra, Nagesh ^a   Knollmann, Bjorn ^a   Magnuson, Mark A ^a   Roden, Dan M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cassette exchange; Heart; Mouse; Sodium channel; Transgenesis

Indexed keywords

COMPLEMENTARY DNA; CRE RECOMBINASE; ISOPROTEIN; RECOMBINASE; SODIUM CHANNEL; THYMIDINE KINASE; VOLTAGE GATED SODIUM CHANNEL;

ACTION POTENTIAL; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; ELECTROPORATION; EMBRYO; EXON; FEMALE; GENE; GENE CASSETTE; GENE FUNCTION; GENE TARGETING; GENE VARIANT; GENETIC RECOMBINATION; HEART; HEART RATE; HOMOLOGOUS RECOMBINATION; HOMOZYGOTE; HUMAN; IN VITRO STUDY; LOXP SITE; MALE; METHODOLOGY; MOUSE; NONHUMAN; ORTHOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN VARIANT; QRS COMPLEX; RECOMBINASE MEDIATED CASSETTE EXCHANGE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RNA TRANSLATION; SCN5A GENE; SODIUM CURRENT; THYMIDINE KINASE GENE; TRANSGENE; TRANSGENIC MOUSE; TRANSGENICS; TRANSLATION INITIATION;

ANIMALIA; MURINAE;

EID: 33751584566     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20247     Document Type: Article

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