메뉴 건너뛰기




Volumn 8, Issue 6, 2006, Pages 451-456

Obesity and insulin resistance: Effects on cardiac structure, function, and substrate metabolism

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CANNABINOID RECEPTOR ANTAGONIST; DEXFENFLURAMINE; FATTY ACID; FENFLURAMINE; INSULIN; LEPTIN; NEUROHORMONE; PROTEIN KINASE B; ROSIGLITAZONE;

EID: 33751558777     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-006-0022-y     Document Type: Review
Times cited : (35)

References (50)
  • 1
    • 30044439080 scopus 로고    scopus 로고
    • Epidemiologic and economic consequences of the global epidemics of obesity and diabetes
    • Yach D, Stuckler D, Brownell KD: Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med 2006, 12:62-66.
    • (2006) Nat Med , vol.12 , pp. 62-66
    • Yach, D.1    Stuckler, D.2    Brownell, K.D.3
  • 2
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • Zimmet P, Alberti KG, Shaw J: Global and societal implications of the diabetes epidemic. Nature 2001, 414:782-787.
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3
  • 3
    • 0036681988 scopus 로고    scopus 로고
    • Obesity and the risk of heart failure
    • Kenchaiah S, Evans JC, Levy D, et al.: Obesity and the risk of heart failure. N Engl J Med 2002, 347:305-313.
    • (2002) N Engl J Med , vol.347 , pp. 305-313
    • Kenchaiah, S.1    Evans, J.C.2    Levy, D.3
  • 4
    • 0016251063 scopus 로고
    • Role of diabetes in congestive heart failure: The Framingham study
    • Kannel WB, Hjortland M, Castelli WP: Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol 1974, 34:29-34.
    • (1974) Am J Cardiol , vol.34 , pp. 29-34
    • Kannel, W.B.1    Hjortland, M.2    Castelli, W.P.3
  • 5
    • 0016283974 scopus 로고
    • Diabetic cardiomyopathy
    • Hamby R, Zoneraich S, Sherman L: Diabetic cardiomyopathy. JAMA 1974, 229:1749-1754.
    • (1974) JAMA , vol.229 , pp. 1749-1754
    • Hamby, R.1    Zoneraich, S.2    Sherman, L.3
  • 6
    • 85047677635 scopus 로고
    • The diabetic heart: Metabolic causes for the development of a cardiomyopathy
    • Rodrigues B, McNeill JH: The diabetic heart: metabolic causes for the development of a cardiomyopathy. Cardiovasc Res 1992, 26:913-922.
    • (1992) Cardiovasc Res , vol.26 , pp. 913-922
    • Rodrigues, B.1    McNeill, J.H.2
  • 7
    • 0037417725 scopus 로고    scopus 로고
    • A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
    • Finck BN, Han X, Courtois M, et al.: A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci U S A 2003, 100:1226-1231.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1226-1231
    • Finck, B.N.1    Han, X.2    Courtois, M.3
  • 8
    • 0020574355 scopus 로고
    • Disparate cardiovascular effects of obesity and arterial hypertension
    • Messerli FH, Sundgaard-Riise K, Reisin E, et al.: Disparate cardiovascular effects of obesity and arterial hypertension. Am J Med 1983, 74:808-812.
    • (1983) Am J Med , vol.74 , pp. 808-812
    • Messerli, F.H.1    Sundgaard-Riise, K.2    Reisin, E.3
  • 9
    • 0035064965 scopus 로고    scopus 로고
    • Obesity cardiomyopathy: Pathophysiology and evolution of the clinical syndrome
    • Alpert MA: Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome. Am J Med Sci 2001, 321:225-236.
    • (2001) Am J Med Sci , vol.321 , pp. 225-236
    • Alpert, M.A.1
  • 10
    • 1942420839 scopus 로고    scopus 로고
    • Alterations in left ventricular structure and function in young healthy obese women: Assessment by echocardiography and tissue Doppler imaging
    • Peterson LR, Waggoner AD, Schechtman KB, et al.: Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue Doppler imaging. J Am Coll Cardiol 2004, 43:1399-1404.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1399-1404
    • Peterson, L.R.1    Waggoner, A.D.2    Schechtman, K.B.3
  • 11
    • 0032840328 scopus 로고    scopus 로고
    • Patterns of body fat deposition in youth and their relation to left ventricular markers of adverse cardiovascular progonosis
    • Mensah GA, Treiber FA, Kapuku GK, et al.: Patterns of body fat deposition in youth and their relation to left ventricular markers of adverse cardiovascular progonosis. Am J Cardiol 1999, 84:583-588.
    • (1999) Am J Cardiol , vol.84 , pp. 583-588
    • Mensah, G.A.1    Treiber, F.A.2    Kapuku, G.K.3
  • 12
    • 0026748322 scopus 로고
    • Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension
    • Ganau A, Devereux RB, Roman MJ, et al.: Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol 1992, 19:1550-1558.
    • (1992) J Am Coll Cardiol , vol.19 , pp. 1550-1558
    • Ganau, A.1    Devereux, R.B.2    Roman, M.J.3
  • 13
    • 0028827534 scopus 로고
    • Relation of duration of morbid obesity to left ventricular mass, systolic function, and diastolic filling, and effect of weight loss
    • Alpert MA, Lambert CR, Panayiotou H, et al. Relation of duration of morbid obesity to left ventricular mass, systolic function, and diastolic filling, and effect of weight loss. Am J Cardiol 1995, 76:1194-1197.
    • (1995) Am J Cardiol , vol.76 , pp. 1194-1197
    • Alpert, M.A.1    Lambert, C.R.2    Panayiotou, H.3
  • 14
    • 8544283794 scopus 로고    scopus 로고
    • Alterations of left ventricular myocardial characteristics associated with obesity
    • Wong CY, O'Moore-Sullivan T, Leano R, et al.: Alterations of left ventricular myocardial characteristics associated with obesity. Circulation 2004, 110:3081-3087.
    • (2004) Circulation , vol.110 , pp. 3081-3087
    • Wong, C.Y.1    O'Moore-Sullivan, T.2    Leano, R.3
  • 15
    • 0031043376 scopus 로고    scopus 로고
    • Cardiopulmonary pathology in patients with sleep apnea/obesity hypoventilation syndrome
    • Ahmed Q, Chung-Park M, Tomashefski JF Jr: Cardiopulmonary pathology in patients with sleep apnea/obesity hypoventilation syndrome. Hum Patbol 1997, 28:264-269.
    • (1997) Hum Patbol , vol.28 , pp. 264-269
    • Ahmed, Q.1    Chung-Park, M.2    Tomashefski Jr, J.F.3
  • 16
    • 0242288653 scopus 로고    scopus 로고
    • Adiposity contributes to differences in left ventricular structure and diastolic function with age in healthy men
    • Gates PE, Gentile CL, Seals DR, Christou DD: Adiposity contributes to differences in left ventricular structure and diastolic function with age in healthy men. J Clin Endocrinol Metab 2003, 88:4884-4890.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4884-4890
    • Gates, P.E.1    Gentile, C.L.2    Seals, D.R.3    Christou, D.D.4
  • 17
    • 0023129491 scopus 로고
    • Cardiac mechanics and function in obese normotensive persons with normal coronary arteries
    • Carabello BA, Gittens L: Cardiac mechanics and function in obese normotensive persons with normal coronary arteries. Am J Cardiol 1987, 59:469-473.
    • (1987) Am J Cardiol , vol.59 , pp. 469-473
    • Carabello, B.A.1    Gittens, L.2
  • 18
    • 0035889569 scopus 로고    scopus 로고
    • Relation of various degrees of body mass index in patients with systemic hypertension to left ventricular mass, cardiac output, and peripheral resistance (The Hypertension Genetic Epidemiology Network Study)
    • Palmieri V, de Simone G, Arnett DK, et al.: Relation of various degrees of body mass index in patients with systemic hypertension to left ventricular mass, cardiac output, and peripheral resistance (The Hypertension Genetic Epidemiology Network Study). Am J Cardiol 2001, 88:1163-1168.
    • (2001) Am J Cardiol , vol.88 , pp. 1163-1168
    • Palmieri, V.1    de Simone, G.2    Arnett, D.K.3
  • 19
    • 0035852666 scopus 로고    scopus 로고
    • Relations of stroke volume and cardiac output to body composition: The strong heart study
    • Collis T, Devereux RB, Roman MJ, et al.: Relations of stroke volume and cardiac output to body composition: the strong heart study. Circulation 2001, 103:820-825.
    • (2001) Circulation , vol.103 , pp. 820-825
    • Collis, T.1    Devereux, R.B.2    Roman, M.J.3
  • 20
    • 0036192939 scopus 로고    scopus 로고
    • Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression
    • Belke DD, Betuing S, Tuttle MJ, et al.: Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest 2002, 109:629-639.
    • (2002) J Clin Invest , vol.109 , pp. 629-639
    • Belke, D.D.1    Betuing, S.2    Tuttle, M.J.3
  • 21
    • 0037020157 scopus 로고    scopus 로고
    • Akt signaling mediates postnatal heart growth in response to insulin and nutritional status
    • Shiojima I, Yefremashvili M, Luo Z, et al.: Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem 2002, 277:37670-37677.
    • (2002) J Biol Chem , vol.277 , pp. 37670-37677
    • Shiojima, I.1    Yefremashvili, M.2    Luo, Z.3
  • 22
    • 0027425259 scopus 로고
    • Insulin resistance is an important determinant of left ventricular mass in the obese
    • Sasson Z, Rasooly Y, Bhesania T, Rasooly I: Insulin resistance is an important determinant of left ventricular mass in the obese. Circulation 1993, 88(4 Pt 1):1431-1436.
    • (1993) Circulation , vol.88 , Issue.4 PART 1 , pp. 1431-1436
    • Sasson, Z.1    Rasooly, Y.2    Bhesania, T.3    Rasooly, I.4
  • 23
    • 0345269255 scopus 로고    scopus 로고
    • Relationship between plasma insulin and left ventricular mass in normotensive participants of the Gubbio Study
    • Vaccaro O, Cardoni O, Cuomo V, et al.: Relationship between plasma insulin and left ventricular mass in normotensive participants of the Gubbio Study. Clin Endocrinol (Oxf) 2003, 58:316-322.
    • (2003) Clin Endocrinol (Oxf) , vol.58 , pp. 316-322
    • Vaccaro, O.1    Cardoni, O.2    Cuomo, V.3
  • 24
    • 22744449914 scopus 로고    scopus 로고
    • Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism
    • Liao Y, Takashima S, Maeda N, et al.: Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc Res 2005, 67:705-713.
    • (2005) Cardiovasc Res , vol.67 , pp. 705-713
    • Liao, Y.1    Takashima, S.2    Maeda, N.3
  • 25
    • 33645814147 scopus 로고    scopus 로고
    • Adiponectin and risk of congestive heart failure
    • Ingelsson E, Riserus U, Berne C, et al.: Adiponectin and risk of congestive heart failure. JAMA 2006, 295:1772-1774.
    • (2006) JAMA , vol.295 , pp. 1772-1774
    • Ingelsson, E.1    Riserus, U.2    Berne, C.3
  • 26
    • 0029992124 scopus 로고    scopus 로고
    • Characterization and regulation of angiotensin II receptors in rat adipose tissue. Angiotensin receptors in adipose tissue
    • Cassis LA, Fettinger MJ, Roe AL, et al.: Characterization and regulation of angiotensin II receptors in rat adipose tissue. Angiotensin receptors in adipose tissue. Adv Exp Med Biol 1996, 396:39-47.
    • (1996) Adv Exp Med Biol , vol.396 , pp. 39-47
    • Cassis, L.A.1    Fettinger, M.J.2    Roe, A.L.3
  • 27
    • 0023681544 scopus 로고
    • Location and regulation of rat angiotensinogen messenger RNA
    • Cassis LA, Saye J, Peach MJ: Location and regulation of rat angiotensinogen messenger RNA. Hypertension 1988, 11:591-596.
    • (1988) Hypertension , vol.11 , pp. 591-596
    • Cassis, L.A.1    Saye, J.2    Peach, M.J.3
  • 28
    • 4644280707 scopus 로고    scopus 로고
    • The global epidemic of obesity: Are we becoming more sympathetic?
    • Davy KP: The global epidemic of obesity: are we becoming more sympathetic? Curr Hypertens Rep 2004, 6:241-246.
    • (2004) Curr Hypertens Rep , vol.6 , pp. 241-246
    • Davy, K.P.1
  • 29
    • 2442492971 scopus 로고    scopus 로고
    • Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women
    • Peterson LR, Herrero P, Schechtman KB, et al.: Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 2004, 109:2191-2196.
    • (2004) Circulation , vol.109 , pp. 2191-2196
    • Peterson, L.R.1    Herrero, P.2    Schechtman, K.B.3
  • 30
    • 0034652225 scopus 로고    scopus 로고
    • Lipotoxic heart disease in obese rats: Implications for human obesity
    • Zhou YT, Grayburn P, Karim A, et al.: Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci U S A 2000, 97:1784-1789.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1784-1789
    • Zhou, Y.T.1    Grayburn, P.2    Karim, A.3
  • 31
    • 0037315085 scopus 로고    scopus 로고
    • Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice
    • Aasum E, Hafstad AD, Severson DL, Larsen TS: Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. Diabetes 2003, 52:434-441.
    • (2003) Diabetes , vol.52 , pp. 434-441
    • Aasum, E.1    Hafstad, A.D.2    Severson, D.L.3    Larsen, T.S.4
  • 32
    • 0035133716 scopus 로고    scopus 로고
    • Myocardial fatty acid oxidation in patients with impaired glucose tolerance
    • Knuuti J, Takala TO, Nagren K, et al.: Myocardial fatty acid oxidation in patients with impaired glucose tolerance. Diabetologia 2001, 44:184-187.
    • (2001) Diabetologia , vol.44 , pp. 184-187
    • Knuuti, J.1    Takala, T.O.2    Nagren, K.3
  • 33
    • 0344848623 scopus 로고    scopus 로고
    • Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: Studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid
    • Turpeinen AK, Takala TO, Nuutila P, et al.: Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid. Diabetes 1999, 48:1245-1250.
    • (1999) Diabetes , vol.48 , pp. 1245-1250
    • Turpeinen, A.K.1    Takala, T.O.2    Nuutila, P.3
  • 34
    • 0030951483 scopus 로고    scopus 로고
    • Uusitupa MI: Abnormal myocardial kinetics of 123I-heptadecanoic acid in subjects with impaired glucose tolerance
    • Turpeinen AK, Kuikka JT, Vanninen E, Uusitupa MI: Abnormal myocardial kinetics of 123I-heptadecanoic acid in subjects with impaired glucose tolerance. Diabetologia 1997, 40:541-549.
    • (1997) Diabetologia , vol.40 , pp. 541-549
    • Turpeinen, A.K.1    Kuikka, J.T.2    Vanninen, E.3
  • 35
    • 0035061419 scopus 로고    scopus 로고
    • A novel mouse model of lipotoxic cardiomyopathy
    • Chiu HC, Kovacs A, Ford DA, et al.: A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest 2001, 107:813-822.
    • (2001) J Clin Invest , vol.107 , pp. 813-822
    • Chiu, H.C.1    Kovacs, A.2    Ford, D.A.3
  • 36
    • 0037453056 scopus 로고    scopus 로고
    • Triglyceride accumulation protects against fatty acid-induced lipotoxicity
    • Listenberger LL, Han X, Lewis SE, et al.: Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A 2003, 100:3077-3082.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3077-3082
    • Listenberger, L.L.1    Han, X.2    Lewis, S.E.3
  • 37
    • 19944429129 scopus 로고    scopus 로고
    • Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression
    • Blendea MC, Jacobs D, Stump CS, et al.: Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression. Am J Physiol Endocrinol Metab 2005, 288:E353-E359.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Blendea, M.C.1    Jacobs, D.2    Stump, C.S.3
  • 38
    • 13444268937 scopus 로고    scopus 로고
    • Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
    • Chiu HC, Kovacs A, Blanton RM, et al.: Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res 2005, 96:225-233.
    • (2005) Circ Res , vol.96 , pp. 225-233
    • Chiu, H.C.1    Kovacs, A.2    Blanton, R.M.3
  • 39
    • 33646036717 scopus 로고    scopus 로고
    • Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice
    • Lee Y, Naseem RH, Park BH, et al.: Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice. Biochem Biophys Res Commun 2006, 344:446-452.
    • (2006) Biochem Biophys Res Commun , vol.344 , pp. 446-452
    • Lee, Y.1    Naseem, R.H.2    Park, B.H.3
  • 40
    • 0031572160 scopus 로고    scopus 로고
    • Cardiac morphology and left ventricular function in normotensive morbidly obese patients with and without congestive heart failure, and effect of weight loss
    • Alpert MA, Terry BE, Mulekar M, et al.: Cardiac morphology and left ventricular function in normotensive morbidly obese patients with and without congestive heart failure, and effect of weight loss. Am J Cardiol 1997, 80:736-740.
    • (1997) Am J Cardiol , vol.80 , pp. 736-740
    • Alpert, M.A.1    Terry, B.E.2    Mulekar, M.3
  • 41
    • 0032196819 scopus 로고    scopus 로고
    • Effects of obesity and weight loss on cardiac function and valvular performance
    • Karason K, Wallentin I, Larsson B, Sjostrom L: Effects of obesity and weight loss on cardiac function and valvular performance. Obes Res 1998, 6:422-429.
    • (1998) Obes Res , vol.6 , pp. 422-429
    • Karason, K.1    Wallentin, I.2    Larsson, B.3    Sjostrom, L.4
  • 42
    • 0034802253 scopus 로고    scopus 로고
    • Left ventricular function and cardiopulmonary performance following surgical treatment of morbid obesity
    • Kanoupakis E, Michaloudis D, Fraidakis O, et al.: Left ventricular function and cardiopulmonary performance following surgical treatment of morbid obesity. Obes Surg 2001, 11:552-558.
    • (2001) Obes Surg , vol.11 , pp. 552-558
    • Kanoupakis, E.1    Michaloudis, D.2    Fraidakis, O.3
  • 43
    • 0033062820 scopus 로고    scopus 로고
    • A weight reduction and weight maintenance program with long-lasting improvement in left ventricular mass and blood pressure
    • Himeno E, Nishino K, Okazaki T, et al.: A weight reduction and weight maintenance program with long-lasting improvement in left ventricular mass and blood pressure. Am J Hypertens 1999, 12:682-690.
    • (1999) Am J Hypertens , vol.12 , pp. 682-690
    • Himeno, E.1    Nishino, K.2    Okazaki, T.3
  • 44
    • 0036777034 scopus 로고    scopus 로고
    • Dietary weight loss decreases serum angiotensin-converting enzyme activity in obese adults
    • Harp JB, Henry SA, DiGirolamo M: Dietary weight loss decreases serum angiotensin-converting enzyme activity in obese adults. Obes Res 2002, 10:985-990.
    • (2002) Obes Res , vol.10 , pp. 985-990
    • Harp, J.B.1    Henry, S.A.2    DiGirolamo, M.3
  • 45
    • 20444504384 scopus 로고    scopus 로고
    • Effects of weight loss after gastric bypass on right and left ventricular function assessed by tissue Doppler imaging
    • Willens HJ, Chakko SC, Byers P, et al.: Effects of weight loss after gastric bypass on right and left ventricular function assessed by tissue Doppler imaging. Am J Cardiol 2005, 95:1521-1524.
    • (2005) Am J Cardiol , vol.95 , pp. 1521-1524
    • Willens, H.J.1    Chakko, S.C.2    Byers, P.3
  • 46
    • 33751573397 scopus 로고    scopus 로고
    • Moderate weight loss decreases myocardial oxygen consumption and cardiac work in obese men and women
    • [abstract]
    • Peterson LR, Mohammed BS, Avidan M, et al.: Moderate weight loss decreases myocardial oxygen consumption and cardiac work in obese men and women [abstract]. J Am Coll Cardiol 2006, 47:105A.
    • (2006) J Am Coll Cardiol , vol.47
    • Peterson, L.R.1    Mohammed, B.S.2    Avidan, M.3
  • 48
    • 0018358145 scopus 로고
    • Reversibility of cardiovascular changes in extreme obesity. Effects of weight reduction through jejunoileostomy
    • Backman L, Freyschuss U, Hallberg D, Melcher A: Reversibility of cardiovascular changes in extreme obesity. Effects of weight reduction through jejunoileostomy. Acta Med Scand 1979, 205:367-373.
    • (1979) Acta Med Scand , vol.205 , pp. 367-373
    • Backman, L.1    Freyschuss, U.2    Hallberg, D.3    Melcher, A.4
  • 49
    • 10244225267 scopus 로고    scopus 로고
    • Enhancement of insulin-stimulated myocardial glucose uptake in patients with type 2 diabetes treated with rosiglitazone
    • Hallsten K, Virtanen KA, Lonngvist F, et al.: Enhancement of insulin-stimulated myocardial glucose uptake in patients with type 2 diabetes treated with rosiglitazone. Diabet Med 2004, 21:1280-1287.
    • (2004) Diabet Med , vol.21 , pp. 1280-1287
    • Hallsten, K.1    Virtanen, K.A.2    Lonngvist, F.3
  • 50
    • 0013772629 scopus 로고
    • Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles
    • Randle PJ, Newsholme EA, Garland PB: Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochem J 1964, 93:652-665.
    • (1964) Biochem J , vol.93 , pp. 652-665
    • Randle, P.J.1    Newsholme, E.A.2    Garland, P.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.