TNF induces distinct gene expression programs in microvascular and macrovascular human endothelial cells

Journal of Leukocyte Biology

Volumn 80, Issue 1, 2006, Pages 174-185

  Viemann, Dorothee ^a,b   Goebeler, Matthias ^c   Schmid, Sybille ^c   Nordhues, Ursula ^a   Klimmek, Kerstin ^a   Sorg, Clemens ^a   Roth, Johannes ^a,b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Gene regulation; Inflammation; Microarray

Indexed keywords

CHEMOKINE; CYTOKINE; OLIGONUCLEOTIDE; TUMOR NECROSIS FACTOR;

ARTICLE; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN; UNINDEXED SEQUENCE;

CHEMOKINES; CYTOKINES; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33751537126     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0905530     Document Type: Article

References (27)

1. Krishnaswamy, G., Kelley, J., Yerra, L., Smith, J. K., Chi, D. S. (1999) Human endothelium as a source of multifunctional cytokines: molecular regulation and possible role in human disease. J. Interferon Cytokine Res. 19, 91-104.
2. Mantovani, A., Garlanda, C., Introna, M., Vecchi, A. (1998) Regulation of endothelial cell function by pro- and anti-inflammatory cytokines. Transplant. Proc. 30, 4239-4243.
3. Peters, K., Unger, R. E., Brunner, J., Kirkpatrick, C. J. (2003) Molecular basis of endothelial dysfunction in sepsis. Cardiovasc. Res. 60, 49-57.
4. Lidington, E. A., Moyes, D. L., McCormack, A. M., Rose, M. L. (1999) A comparison of primary endothelial cells and endothelial cell lines for studies of immune interactions. Transpl. Immunol. 7, 239-246.
5. Kallmann, B. A., Wagner, S., Hummel, V., Buttmann, M., Bayas, A., Tonn, J. C., Rieckmann, P. (2002) Characteristic gene expression profile of primary human cerebral endothelial cells. FASEB J. 16, 589-591.
6. Chi, J. T., Chang, H. Y., Haraldsen, G., Jahnsen, F. L., Troyanskaya, O. G., Chang, D. S., Wang, Z., Rockson, S. G., van de Rijn, M., Botstein, D., Brown, P. O. (2003) Endothelial cell diversity revealed by global expression profiling. Proc. Natl. Acad. Sci. USA 100, 10623-10628.
7. Franzen, B., Duvefelt, K., Jonsson, C., Engelhardt, B., Ottervald, J., Wickman, M., Yang, Y., Schuppe-Koistinen, I. (2003) Gene and protein expression profiling of human cerebral endothelial cells activated with tumor necrosis factor-α. Brain Res. Mol. Brain Res. 115, 130-146.
8. Viemann, D., Goebeler, M., Schmid, S., Klimmek, K., Sorg, C., Ludwig, S., Roth, J. (2004) Transcriptional profiling of IKK2/NF-κ B- and p38 MAP kinase-dependent gene expression in TNF-α-stimulated primary human endothelial cells. Blood 103, 3365-3373.
9. Denk, A., Goebeler, M., Schmid, S., Berberich, I., Ritz, O., Lindemann, D., Ludwig, S., Wirth, T. (2001) Activation of NF-κ B via the Iκ B kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells. J. Biol. Chem. 276, 28451-28458.
10. Liu, W., Saint, D. A. (2002) A new quantitative method of real time reverse transcription polymerase chain reaction assay based on simulation of polymerase chain reaction kinetics. Anal. Biochem. 302, 52-59.
11. Goebeler, M., Gillitzer, R., Kilian, K., Utzel, K., Brocker, E. B., Rapp, U. R., Ludwig, S. (2001) Multiple signaling pathways regulate NF-κB-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells. Blood 97, 46-55.
12. Jacquot, S. (2000) CD27/CD70 interactions regulate T dependent B cell differentiation. Immunol. Res. 21, 23-30.
13. Butt, A. J., Dickson, K. A., McDougall, F., Baxter, R. C. (2003) Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo. J. Biol. Chem. 278, 29676-29685.
14. Pilewski, J. M., Liu, L., Henry, A. C., Knauer, A. V., Feghali-Bostwick, C. A. (2005) Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition. Am. J. Pathol. 166, 399-407.
15. Xu, Q., Yan, B., Li, S., Duan, C. (2004) Fibronectin binds insulin-like growth factor-binding protein 5 and abolishes its ligand-dependent action on cell migration. J. Biol. Chem. 279, 4269-4277.
16. Milner, C. M., Day, A. J. (2003) TSG-6: a multifunctional protein associated with inflammation. J. Cell Sci. 116, 1863-1873.
17. Nagase, H., Woessner Jr., J. F. (1999) Matrix metalloproteinases. J. Biol. Chem. 274, 21491-21494.
18. Law, S. F., Zhang, Y. Z., Klein-Szanto, A. J., Golemis, E. A. (1998) Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. Mol. Cell. Biol. 18, 3540-3551.
19. Suzuki, T., Nakamoto, T., Ogawa, S., Seo, S., Matsumura, T., Tachibana, K., Morimoto, C., Hirai, H. (2002) MICAL, a novel CasL interacting molecule, associates with vimentin. J. Biol. Chem. 277, 14933-14941.
20. Geiser, T., Dewald, B., Ehrengruber, M. U., Clark-Lewis, I., Baggiolini, M. (1993) The interleukin-8-related chemotactic cytokines GRO α, GRO β, and GRO γ activate human neutrophil and basophil leukocytes. J. Biol. Chem. 268, 15419-15424.
21. Van Damme, J., Wuyts, A., Froyen, G., Van Coillie, E., Struyf, S., Billiau, A., Proost, P., Wang, J. M., Opdenakker, G. (1997) Granulocyte chemotactic protein-2 and related CXC chemokines: from gene regulation to receptor usage. J. Leukoc. Biol. 62, 563-569.
22. Shang, X. Z., Issekutz, A. C. (1999) Enhancement of monocyte transendothelial migration by granulocyte-macrophage colony-stimulating factor: requirement for chemoattractant and CD11a/CD18 mechanisms. Eur. J. Immunol. 29, 3571-3582.
23. Cheng, S. S., Lai, J. J., Lukacs, N. W., Kunkel, S. L. (2001) Granulocyte-macrophage colony stimulating factor up-regulates CCR1 in human neutrophils. J. Immunol. 166, 1178-1184.
24. Umehara, H., Bloom, E. T., Okazaki, T., Nagano, Y., Yoshie, O., Imai, T. (2004) Fractalkine in vascular biology: from basic research to clinical disease. Arterioscler. Thromb. Vasc. Biol. 24, 34-40.
25. Willette, R. N., Gu, J. L., Lysko, P. G., Anderson, K. M., Minehart, H., Yue, T. (1999) BMP-2 gene expression and effects on human vascular smooth muscle cells. J. Vasc. Res. 36, 120-125.
26. Armengol, M. P., Cardoso-Schmidt, C. B., Fernandez, M., Ferrer, X., Pujol-Borrell, R., Juan, M. (2003) Chemokines determine local lymphoneogenesis and a reduction of circulating CXCR4+ T and CCR7 B and T lymphocytes in thyroid autoimmune diseases. J. Immunol. 170, 6320-6328.
27. Drayton, D. L., Chan, K., Lesslauer, W., Lee, J., Ying, X. Y., Ruddle, N. H. (2002) Lymphocyte traffic in lymphoid organ neogenesis: differential roles of Ltα and LTαβ. Adv. Exp. Med. Biol. 512, 43-48.