Syntheses of [14C]BAY 59-7939 and its radiolabeled metabolite M-4

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 49, Issue 11, 2006, Pages 929-934

  Pleiss, U ^a   Seidel, D ^a   Grosser, R ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Amide formation; Carbon 14 synthesis; Factor Xa inhibitor

Indexed keywords

METABOLITES;

ABSORPTION DISTRIBUTION METABOLISM AND EXCRETIONS; AMIDE FORMATION; CARBON 14; CARBON-14 SYNTHESIS; CARBOXAMIDES; CLINICAL DEVELOPMENT; DRUG ABSORPTION; FACTOR XA INHIBITOR; RADIOCHEMICAL YIELD;

AMINO ACIDS;

4 [4 [5 (AMINOMETHYL) 2 OXO 1,3 OXAZOLIDIN 3 YL]PHENYL]MOR PHOLIN 3 ONE; 5 CHLOROTHIOPHENE 5 CARBOXYLIC ACID; AMIDE; BENZENE DERIVATIVE; CARBON 14; CARBOXYLIC ACID DERIVATIVE; DRUG METABOLITE; GLYCINE; OXAZOLIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; RIVAROXABAN; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ABSORPTION; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; EXPERIMENTAL MODEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; THROMBOEMBOLISM;

EID: 33751511222     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1103     Document Type: Article

References (5)

1. Mann KG, Brummel K, Butenas S. J Thromb Haemost 2003; 1: 1504-1514.
2. Perzborn EP, Strassburger J, Wilmen A, Pohlmann J, Roehrig S, Schlemmer K-H, Straub A. J Thromb Haemost 2005; 3: 514-521.
3. Roehrig S, Straub A, Pohlmann J, Lampe T, Pernerstorfer J, Schlemmer K-H, Reinemer P, Perzborn EP. J Med Chem 2005; 48: 5900-5908.
4. Aitken RA, Bibby MC, Bielefeldt F, Double JA, Laws AL. Arch Pharm 1998; 331(12): 405-411.
5. Lange W, Boemer B, Grosser R, Arlt D. European Patent, no. EP 0379917, 13.01.1990.