Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase

Biochemical and Biophysical Research Communications

Volumn 352, Issue 1, 2007, Pages 259-263

  Abe, Ikuro ^a,b   Abe, Tsuyoshi ^a   Lou, Weiwei ^a   Masuoka, Takayoshi ^a   Noguchi, Hiroshi ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Active site; Biosynthesis; Site directed mutagenesis; Squalene epoxidase; Substrate specificity

Indexed keywords

SQUALENE DERIVATIVE; SQUALENE MONOOXYGENASE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; PRIORITY JOURNAL; PROTEIN FOLDING; SITE DIRECTED MUTAGENESIS; STATISTICAL SIGNIFICANCE; STEREOCHEMISTRY; WILD TYPE;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; HUMANS; KINETICS; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SQUALENE MONOOXYGENASE;

EID: 33751427434     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.11.014     Document Type: Article

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