The expression of insulin signal transduction molecules and islet α cell insulin resistance

National Medical Journal of China

Volumn 86, Issue 36, 2006, Pages 2542-2546

  Du, Rui Qin ^a   Li, Hong Liang ^a   Yang, Wen Ying ^a   Xiao, Jian Zhong ^a   Lou, Da Jun ^a   Wang, Bing ^a   Bai, Xiu Ping ^a   Pan, Lin ^a  

^a CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

Author keywords

Free fatty acids; Insulin resistance; Islet cells

Indexed keywords

FATTY ACID; GLUCAGON; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; STREPTOZOCIN; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CLAMP; CONTROLLED STUDY; CORRELATION ANALYSIS; EXPERIMENTAL MODEL; FEEDING; GENE DELETION; GENE EXPRESSION; GLUCOSE INFUSION; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID DIET; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; RANDOMIZATION; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOOD GLUCOSE; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION; GLUCAGON; GLUCOSE CLAMP TECHNIQUE; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, INSULIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

EID: 33751415720     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Aiaujo ER, Amaral ME, Souza CT, et al. Blockade of IRS-1 in isolated rat pancreatic islets improves glucose-induced insulin secretion. FEBS Lett,2002,531:437-432.
2. Kaneko K, Shirotani T, Araki E, et al. Insulin inhibits glucagon secretion by the activation of PI3-kinase in ln-RI-G9 cells. Diabetes Res Clin Pract,1999,44:83-92.
3. Chinese source. 2005,3:196-198.
4. Chinese source. 2005,44:601-605.
5. Reaven GM, Chen Y, Golay A, et al. Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab,1987,64:106-110.
6. Mitrako A, Kelley D, Mokan M, et al. Role of reduceds suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med,1992,326:22-29.
7. Larsson H, Ahren B. Glucose intolerance is predicted by low insulin secretion and high glucagon secretion:outcome of a prospective study in postmenopausal caucasian women. Diabetologia, 2000, 43: 194-202.
8. Larsson H, Ahren B. Islet disfunction in insulin resistance involves impaired insulin secretion and increased glucagon secretion in postmenopausal women with impaired glucose tolerance. Diabetes Care,2000,23:650-657.
9. Li J, Li X, Luo M, et al. Evidence for insulin resistance of pancreatic α cells. Diabetologia,2004,47:(Suppl 1) A169.
10. Rhodes CJ. Type 2 diabetes a matter of beta-cell life and death? Science,2005,307:380-384.
11. Jing H, Reziwanggu A, Jianguo C, et al. The short-term effect of fatty acids on glucagon secretion is influenced by their chain length, spatial configuration, and degree of unsaturation: studies in vitro. Meta Clin Exp,2005,54:1329-1336.