Role of nitric oxide in the vasorelaxant and hypotensive effects of extracts and purified tannins from Geum japonicum

Journal of Ethnopharmacology

Volumn 109, Issue 1, 2007, Pages 128-133

  Xie, Yi Wu ^a   Xu, Hong Xi ^a   Dong, Hui ^a   Fiscus, Ronald R ^a   But, Paul P H ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Geum japonicum; Hypertension; Nitric oxide; Rosaceae; Tannin

Indexed keywords

5 DESGALLOYLLSTACHYURIN; ACETONE; ARGININE; BUTANOL; CASUARIIN; CYCLIC GMP; GEUM JAPONICUM EXTRACT; METHYLENE BLUE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; PENTA O GALLOYL BETA GLUCOSIDE; PHENYLEPHRINE; PLANT EXTRACT; TANNIN DERIVATIVE;

ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; BIOSYNTHESIS; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG POTENCY; DRUG PURIFICATION; DRUG SYNTHESIS; GEUM JAPONICUM; HYPERTENSION; HYPOTENSION; ISOLATED ORGAN; MALE; MEAN ARTERIAL PRESSURE; MEDICINAL PLANT; NONHUMAN; RAT; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GEUM; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHENYLEPHRINE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TANNINS; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

GEUM JAPONICUM; ROSACEAE;

EID: 33751405894     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2006.07.015     Document Type: Article

References (21)

1. Chan G.H., and Fiscus R.R. Severe impairment of CGRP-induced hypotension in vivo and vasorelaxation in vitro in elderly rats. European Journal of Pharmacology 434 (2002) 133-139
2. Chen X., Salwinski S., and Lee T.J.F. Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway. Clinical and Experimental Pharmacology and Physiology 24 (1997) 958-959
3. Chiesi M., and Schwaller R. Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin. Biochemical Pharmacology 49 (1995) 495-501
4. Dong H., Chen S.X., Kini R.M., and Xu H.X. Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. Journal of Natural Products 61 (1998) 1356-1360
5. Fiscus R.R., Zhou H.L., Wang X., Han C., Ali S., Joyce C.D., and Murad F. Calcitonin gene-related peptide (CGRP)-induced cyclic AMP, cyclic GMP and vasorelaxant responses in rat thoracic aorta are antagonized by blockers of endothelium-derived relaxant factor. Neuropeptides 20 (1991) 133-143
6. Fitzpatrick D.F., Hirschfield S.L., and Coffey R.G. Endothelium-dependent vasorelaxing activity of wine and other grape products. American Journal of Physiology 265 (1993) H774-H778
7. Flesch M., Schwarz A., and Bohm M. Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries. American Journal of Physiology 275 (1998) H1183-H1190
8. Haslam E. Natural polyphenols (vegetable tannins) as drugs: possible modes of action. Journal of Natural Products 59 (1996) 205-215
9. Hatano T., Edamatsu R., Hiramatsu M., Mori A., Fujita Y., Yasuhara T., Yoshida T., and Okuda T. Effects of the interaction of tannins with co-existing substances. VI. Effects of tannins and related polyphenols on superoxide anion radical, and on 1,1-diphenyl-2-picrylhydrazyl radical. Chemical and Pharmaceutical Bulletin 37 (1989) 2016-2021
10. Inokuchi J., Okabe H., Yamauchi T., Nagamatsu A., Nonaka G., and Nishioka I. Antihypertensive substance in seeds of Areca catechu L. Life Sciences 38 (1986) 1375-1382
11. Khanbabaee K., and van Ree T. Tannins: classification and definition. Natural Product Reports 18 (2001) 641-649
12. Kim H.Y., Chen X., and Gillis C.N. Ginsenosides protect pulmonary vascular endothelium against free radical-induced injury. Biochemical and Biophysical Research Communications 189 (1992) 670-676
13. Liu J.C., Hsu F.L., Tsai J.C., Chan P., Liu J.Y., Thomas G.N., Tomlinson B., Lo M.Y., and Lin J.Y. Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiotensin converting enzyme. Life Sciences 73 (2003) 1543-1555
14. Moncada S., Palmer R.M., and Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacological Reviews 43 (1991) 109-142
15. Nakagawa T., and Yokozawa T. Direct scavenging of nitric oxide and superoxide by green tea. Food and Chemical Toxicology 40 (2002) 1745-1750
16. Okuda T., Yoshida T., and Hatano T. Ellagitannins as active constituents of medicinal plants. Planta Medica 55 (1989) 117-122
17. Russell J.A., and Rohrbach M.S. Tannin induces endothelium-dependent contraction and relaxation of rabbit pulmonary artery. American Review of Respiratory Disease 139 (1989) 498-503
18. Singleton V.L. Naturally occurring food toxicants: phenolic substances of plant origin common in foods. Advances in Food Research 27 (1981) 149-242
19. Xie Y.W., Ming D.S., Xu H.X., Dong H., and But P.P.H. Vasorelaxing effects of Caesalpinia sappan: involvement of endogenous nitric oxide. Life Sciences 67 (2000) 1913-1918
20. Yoshida T., Okuda T., Memon M.U., and Shingu T. Tannins of rosaceous medicinal plants. Part 2. Gemins A, B and C, new dimeric ellagitannins from Geum japonicum. Journal of the Chemical Society, Perkin Transactions 1 (1985) 315-321
21. Zhang X., Xie Y.W., Nasjletti A., Xu X., Wolin M.S., and Hintze T.H. ACE inhibitors promote nitric oxide accumulation to modulate myocardial oxygen consumption. Circulation 95 (1997) 176-182