Exchange of P/V genes between two non-cytopathic simian virus 5 variants results in a recombinant virus that kills cells through death pathways that are sensitive to caspase inhibitors

Journal of General Virology

Volumn 87, Issue 12, 2006, Pages 3643-3648

  Dillon, Patrick J ^a   Wansley, Elizabeth K ^a,b   Young, Virginia A ^a   Alexander Miller, Martha A ^a   Parks, Griffith D ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9 INHIBITOR; GENE PRODUCT; VIRUS PROTEIN; VIRUS PROTEIN V;

APOPTOSIS; ARTICLE; CELL DEATH; CELL KILLING; CELL VIABILITY; CHIMERA; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SIMIAN PARAINFLUENZA VIRUS 5; VIRUS CELL INTERACTION; VIRUS GENE; VIRUS GENOME; VIRUS RECOMBINANT; VIRUS VIRULENCE;

APOPTOSIS; CASPASE 8; CASPASE 9; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CYTOPATHOGENIC EFFECT, VIRAL; ENZYME INHIBITORS; EPITHELIAL CELLS; HELA CELLS; HUMANS; PHOSPHOPROTEINS; RECOMBINATION, GENETIC; SIMIAN VIRUS 5; VIRAL PROTEINS; VIRAL STRUCTURAL PROTEINS;

PARAMYXOVIRIDAE; SIMIAN VIRUS 5;

EID: 33751403642     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.82242-0     Document Type: Article

References (31)

1. Andrejeva, J., Childs, K. S., Young, D. F., Carlos, R. S., Stock N., Goodbourn, S. & Randall, R. E. (2004). The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter. Proc Natl Acad Sci U S A 101, 17264-17269.
2. Arimilli, S., Alexander-Miller, M. A. & Parks, G. D. (2006). A simian virus 5 (SV5) P/V mutant is less cytopathic than wild-type SV5 in human dendritic cells and is a more effective activator of dendritic cell maturation and function. J Virol 80, 3416-3427.
3. Barber, G. (2001). Host defense, viruses and apoptosis. Cell Death Differ 8, 113-126.
4. Bitzer, M., Prinz, F., Bauer, M., Spiegel, M., Neubert, W. J. Gregor, M., Schulze-Osthoff, K. & Lauer, U. (1999). Sendai virus infection induces apoptosis through activation of caspase-8 (FLICE) and caspase-3 (CPP32). J Virol 73, 702-708.
5. Chatziandreou, N., Young, D., Andrejeva, J., Goodbourn, S. & Randall, R. E. (2002). Differences in interferon sensitivity and biological properties of two related isolates of simian virus 5; a model for virus persistence. Virology 293, 234-242.
6. Choppin, P. W. (1964). Multiplication of a myxovirus (SV5) with minimal cytopathic effects and without interference. Virology 23, 224-233.
7. Esolen, L. M., Park, S. W., Hardwick, J. M. & Griffin, D. E. (1995). Apoptosis as a cause of death in measles virus-infected cells. J Virol 69, 3955-3958.
8. Garcin, D., Taylor, G., Tanebayashi, K., Compans, R. & Kolakofsky, D. (1998). The short Sendai virus leader region controls induction of programmed cell death. Virology 243, 340-353.
9. He, B., Paterson, R. G., Ward, C. D. & Lamb, R. A. (1997). Recovery of infectious SV5 from cloned DNA and expression of a foreign gene. Virology 237, 249-260.
10. He, B., Lin, G. Y., Durbin, J. E., Durbin, R. K. & Lamb, R. A. (2001). The SH integral membrane protein of the paramyxovirus simian virus 5 is required to block apoptosis in MDBK cells. J Virol 75, 4068-4079.
11. He, B., Paterson, R. G., Stock, N., Durbin, J. E., Durbin, R. K., Goodbourn, S., Randall, R. E. & Lamb, R. A. (2002). Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: the multifunctional V protein blocks both interferon-β induction and interferon signaling. Virology 303, 15-32.
12. Iseni, F., Garcin, D., Nishio, M., Kedersha, N., Anderson, P. & Kolakofsky, D. (2002). Sendai virus trailer RNA binds TIAR, a cellular protein involved in virus-induced apoptosis. EMBO J 21, 5141-5150.
13. Kopecky, S. A. & Lyles, D. S. (2003). Contrasting effects of matrix protein on apoptosis in HeLa and BHK cells infected with vesicular stomatitis virus are due to inhibition of host gene expression. J Virol 77, 4658-4669.
14. Kopecky, S. A., Willingham, M. C. & Lyles, D. S. (2001). Matrix protein and another viral component contribute to induction of apoptosis in cells infected with vesicular stomatitis virus. J Virol 75, 12169-12181.
15. Kotelkin, A., Prikhod'ko, E. A., Cohen, J. I., Collins, P. L. & Bukreyev, A. (2003). Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand. J Virol 77, 9156-9172.
16. Koyama, A. H., Irie, H., Kato, A., Nagai, Y. & Adachi, A. (2003). Virus multiplication and induction of apoptosis by Sendai virus: role of the C proteins. Microbes Infect 5, 373-378.
17. Lamb, R. A. & Kolakofsky, D. (1996). Paramyxoviridae: the viruses and their replication. In Fields Virology, 3rd edn, pp. 1177-1204. Edited by B. N. Fields, D. M. Knipe & P. M. Howley. Philadelphia, PA: Lippincott-Raven.
18. Lin, Y., Bright, A. C., Rothermel, T. A. & He, B. (2003). Induction of apoptosis by paramyxovirus simian virus 5 lacking a small hydrophobic gene. J Virol 77, 3371-3383.
19. Ludwig, S., Pleschka, S., Planz, O. & Wolff, T. (2006). Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells. Cell Microbiol 8, 375-386.
20. Lyles, D. S. (2000). Cytopathogenesis and inhibition of host gene expression by RNA viruses. Microbiol Mol Biol Rev 64, 709-724.
21. Parks, G. D., Young, V. A., Koumenis, C., Wansley, E. K., Layer, J. L. & Cooke, K. M. (2002). Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus. Virology 293, 192-203.
22. Precious, B., Young, D. F., Bermingham, A., Fearns, R., Ryan, M. & Randall, R. E. (1995). Inducible expression of the P, V, and NP genes of the paramyxovirus simian virus 5 in cell lines and an examination of NP-P and NP-V interactions. J Virol 69, 8001-8010.
23. Randall, R. E. & Bermingham, A. (1996). NP:P and NP:V interactions of the paramyxovirus simian virus 5 examined using a novel protein: protein capture assay. Virology 224, 121-129.
24. Roulston, A., Marcellus, R. C. & Branton, P. E. (1999). Viruses and apoptosis. Annu Rev Microbiol 53, 577-628.
25. Sun, M., Rothermel, T. A., Shuman, L., Aligo, J. A., Xu, S., Lin, Y., Lamb, R. A. & He, B. (2004). Conserved cysteine-rich domain of paramyxovirus simian virus 5 V protein plays an important role in blocking apoptosis. J Virol 78, 5068-5078.
26. Wansley, E. K. & Parks, G. D. (2002). Naturally occurring substitutions in the P/V gene convert the noncytopathic paramyxovirus simian virus 5 into a virus that induces alpha/beta interferon synthesis and cell death. J Virol 76, 10109-10121.
27. Wansley, E. K., Grayson, J. M. & Parks, G. D. (2003). Apoptosis induction and interferon signaling but not IFN-β promoter induction by an SV5 P/V mutant are rescued by coinfection with wild-type SV5. Virology 316, 41-54.
28. Wiegand, M., Bossow, S. & Neubert, W. J. (2005). Sendai virus trailer RNA simultaneously blocks two apoptosis-inducing mechanisms in a cell type-dependent manner. J Gen Virol 86, 2305-2314.
29. Young, D. F., Didcock, L., Goodbourn, S. & Randall, R. E. (2000). Paramyxoviruses use distinct virus-specific mechanisms to circumvent the interferon response. Virology 269, 383-390.
30. Young, V. A., Dillon, P. J. & Parks, G. D. (2006). Variants of the paramyxovirus simian virus 5 with accelerated or delayed viral gene expression activate proinflammatory cytokine synthesis. Virology 350, 90-102.
31. Zorn, U., Dallmann, I., Grosse, J., Kirchner, H., Poliwoda, H. & Atzpodien, J. (1994). Induction of cytokines and cytotoxicity against tumor cells by Newcastle disease virus. Cancer Biother 9, 225-235.