Cutaneous vasculitis update: Small vessel neutrophilic vasculitis syndromes

American Journal of Dermatopathology

Volumn 28, Issue 6, 2006, Pages 486-506

  Carlson, J Andrew ^a   Chen, Ko Ron ^b  

^a ALBANY MEDICAL COLLEGE   (United States)

^b SAISEIKAI CENTRAL HOSPITAL   (Japan)

Author keywords

Antineutrophil cytoplasmic antibodies; Direct immunofluorescence; Neutrophilic small and or medium sized vessel vasculitis; Primary and secondary systemic vasculitis

Indexed keywords

ALLOPURINOL; CEFACLOR; COLONY STIMULATING FACTOR; HYDRALAZINE; ISOTRETINOIN; METHOTREXATE; MINOCYCLINE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PENICILLAMINE; PHENYTOIN; PROPYLTHIOURACIL; TUMOR NECROSIS FACTOR ANTIBODY;

ANAPHYLACTOID PURPURA; BEHCET DISEASE; CHRONIC DISEASE; CHURG STRAUSS SYNDROME; CONNECTIVE TISSUE DISEASE; CRYOGLOBULINEMIA; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DRUG INDUCED DISEASE; ERYTHEMA; ERYTHEMA ELEVATUM DIUTINUM; GRANULOMA; HISTOLOGY; HUMAN; INFECTION; LEUKOCYTOCLASTIC VASCULITIS; MICROSCOPIC POLYANGIITIS; PARANEOPLASTIC SYNDROME; PRIORITY JOURNAL; PSEUDOTUMOR; REVIEW; SJOEGREN SYNDROME; SKIN BIOPSY; SYNDROME DELINEATION; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC VASCULITIS; URTICARIA; VASCULITIS; WEGENER GRANULOMATOSIS;

ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ARTHRITIS, RHEUMATOID; BIOPSY; CONNECTIVE TISSUE DISEASES; CRYOGLOBULINEMIA; DIAGNOSIS, DIFFERENTIAL; DRUG ERUPTIONS; HUMANS; INFECTION; LUPUS ERYTHEMATOSUS, SYSTEMIC; PARANEOPLASTIC SYNDROMES; PURPURA, SCHOENLEIN-HENOCH; SKIN; SKIN DISEASES, VASCULAR; URTICARIA; VASCULITIS; VASCULITIS, HYPERSENSITIVITY; WEGENER GRANULOMATOSIS;

EID: 33751377073     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.dad.0000246646.45651.a2     Document Type: Review

References (254)

1. D'Cruz D, Cervera R, Olcay Aydintug A, et al. Systemic lupus erythematosus evolving into systemic vasculitis: a report of five cases. Br J Rheumatol. 1993;32:154-157.
2. Covic A, Mutica C, Ignat A, et al. [Retrospective study of 97 ANCA-positive patients: epidemiologic and clinical spectrum]. Rev Med Chir Soc Med Nat Iasi. 2004;108:305-310.
3. Carlson JA, Ng BT, Chen KR. Cutaneous Vasculitis Update: Diagnostic Criteria, Classification, Epidemiology, Etiology, Pathogenesis, Evaluation and Prognosis. Am J Dermatopathol. 2005;27:504-528.
4. Rao JK, Allen NB, Pincus T. Limitations of the 1990 American College of Rheumatology classification criteria in the diagnosis of vasculitis. Ann Intern Med. 1998;129:345-352.
5. Jennette JC, Falk RJ. Do vasculitis categorization systems really matter? Curr Rheumatol Rep. 2000;2:430-438.
6. Watts RA, Scott DG. Classification and epidemiology of the vasculitides. Baillieres Clin Rheumatol. 1997;11:191-217.
7. Gibson LE. Cutaneous vasculitis update. Dermatol Clin. 2001;19:603-615.
8. Jorizzo JL. Vasculitis Update 1999. American Society of Dermatopathology 36th Annual Meeting: La Jolla, CA; 5 November 1999.
9. Lane SE, Watts RA, Shepstone L, et al. Primary systemic vasculitis: clinical features and mortality. QJM. 2005;98:97-111.
10. Lane SE, Watts RA, Barker TH, Scott DG. Evaluation of the Sorensen diagnostic criteria in the classification of systemic vasculitis. Rheumatology (Oxford). 2002;41:1138-1141.
11. Sorensen SF, Slot O, Tvede N, et al. A prospective study of vasculitis patients collected in a five year period: evaluation of the Chapel Hill nomenclature. Ann Rheum Dis. 2000;59:478-482.
12. Watts RA, Jolliffe VA, Carruthers DM, et al. Effect of classification on the incidence of polyarteritis nodosa and microscopic polyangiitis. Arthritis Rheum. 1996;39:1208-1212.
13. Sais G, Vidaller A, Jucgla A, et al. Prognostic factors in leukocytoclastic vasculitis: a clinicopathologic study of 160 patients. Arch Dermatol. 1998;134:309-315.
14. Helander SD, De Castro FR, Gibson LE. Henoch-Schonlein purpura: clinicopathologic correlation of cutaneous vascular IgA deposits and the relationship to leukocytoclastic vasculitis. Acta Derm Venereol. 1995;75:125-129.
15. Barnadas MA, Perez E, Gich I, et al. Diagnostic, prognostic and pathogenic value of the direct immunofluorescence test in cutaneous leukocytoclastic vasculitis. Int J Dermatol. 2004;43:19-26.
16. Magro CM, Crowson AN. A clinical and histologic study of 37 cases of immunoglobulin A-associated vasculitis. Am J Dermatopathol. 1999;21:234-240.
17. Brons RH, de Jong MC, de Boer NK, et al. Detection of immune deposits in skin lesions of patients with Wegener's granulomatosis. Ann Rheum Dis. 2001;60:1097-1102.
18. Daoud MS, Gibson LE, DeRemee RA, et al. Cutaneous Wegener's granulomatosis: clinical, histopathologic, and immunopathologic features of thirty patients. J Am Acad Dermatol. 1994;31:605-612.
19. Sanchez NP, Van Hale HM, Su WP. Clinical and histopathologic spectrum of necrotizing vasculitis. Report of findings in 101 cases. Arch Dermatol. 1985;121:220-224.
20. Davis MD, Daoud MS, McEvoy MT, et al. Cutaneous manifestations of Churg-Strauss syndrome: a clinicopathologic correlation. J Am Acad Dermatol. 1997;37:199-203.
21. Chen KR, Toyohara A, Suzuki A, et al. Clinical and histopathological spectrum of cutaneous vasculitis in rheumatoid arthritis. Br J Dermatol. 2002;147:905-913.
22. Stone JH, Nousari HC. "Essential" cutaneous vasculitis: what every rheumatologist should know about vasculitis of the skin. Curr Opin Rheumatol. 2001;13:23-34.
23. Resnick AH, Esterly NB. Vasculitis in children. Int J Dermatol. 1985;24:139-146.
24. Ratnam KV, Boon YH, Pang BK. Idiopathic hypersensitivity vasculitis: clinicopathologic correlation of 61 cases. Int J Dermatol. 1995;34:786-789.
25. Watts RA, Jolliffe VA, Grattan CE, et al. Cutaneous vasculitis in a defined population-clinical and epidemiological associations. J Rheumatol. 1998;25:920-924.
26. Dammacco F, Sansonno D, Piccoli C, et al. The cryoglobulins: an overview. Eur J Clin Invest. 2001;31:628-638.
27. Chen KR. Cutaneous polyarteritis nodosa: a clinical and histopathological study of 20 cases. J Dermatol. 1989;16:429-442.
28. Minkowitz G, Smoller BR, McNutt NS. Benign cutaneous polyarteritis nodosa. Relationship to systemic polyarteritis nodosa and to hepatitis B infection. Arch Dermatol. 1991;127:1520-1523.
29. Sais G, Vidaller A, Servitje O, et al. Leukocytoclastic vasculitis and common variable immunodeficiency: successful treatment with intravenous immune globulin. J Allergy Clin Immunol. 1996;98:232-233.
30. Mehregan DR, Hall MJ, Gibson LE. Urticarial vasculitis: a histopathologic and clinical review of 72 cases. J Am Acad Dermatol. 1992;26:441-448.
31. Davis MD, Daoud MS, Kirby B, et al. Clinicopathologic correlation of hypocomplementemic and normocomplementemic urticarial vasculitis. J Am Acad Dermatol. 1998;38:899-905.
32. Lotti T, Ghersetich I, Comacchi C, et al. Cutaneous small-vessel vasculitis. J Am Acad Dermatol. 1998;39:667-687.
33. Garcia-Porrua C, Llorca J, Gonzalez-Louzao C, et al. Hypersensitivity vasculitis in adults: a benign disease usually limited to skin. Clin Exp Rheumatol. 2001;19:85-88.
34. Kelly RI, Opie J, Nixon R. Golfer's vasculitis. Australas J Dermatol. 2005;46:11-14.
35. Prins M, Veraart JC, Vermeulen AH, et al. Leucocytoclastic vasculitis induced by prolonged exercise. Br J Dermatol. 1996;134:915-918.
36. Falk RJ, Jennette JC. ANCA small-vessel vasculitis. J Am Soc Nephrol. 1997;8:314-322.
37. Ioannidou DJ, Krasagakis K, Daphnis EK, et al. Cutaneous small vessel vasculitis: an entity with frequent renal involvement. Arch Dermatol. 2002;138:412-414.
38. Jones RR, Bhogal B, Dash A, et al. Urticaria and vasculitis: a continuum of histological and immunopathological changes. Br J Dermatol. 1983;108:695-703.
39. Wisnieski JJ. Urticarial vasculitis. Curr Opin Rheumatol. 2000;12:24-31.
40. Davis MD, Brewer JD. Urticarial vasculitis and hypocomplementemic urticarial vasculitis syndrome. Immunol Allergy Clin North Am. 2004;24:183-213.
41. Black AK. Urticarial vasculitis. Clin Dermatol. 1999;17:565-569.
42. Monroe EW. Urticarial vasculitis: an updated review. J Am Acad Dermatol. 1981;5:88-95.
43. Sanchez NP, Winkelmann RK, Schroeter AL, et al. The clinical and histopathologic spectrums of urticarial vasculitis: study of forty cases. J Am Acad Dermatol. 1982;7:599-605.
44. Blanco R, Martinez-Taboada VM, Rodriguez-Valverde V, et al. Henoch-Schonlein purpura in adulthood and childhood: two different expressions of the same syndrome. Arthritis Rheum. 1997;40:859-864.
45. Saulsbury FT. Henoch-Schonlein purpura. Curr Opin Rheumatol. 2001;13:35-40.
46. Piette WW, Stone MS. A cutaneous sign of IgA-associated small dermal vessel leukocytoclastic vasculitis in adults (Henoch-Schonlein purpura). Arch Dermatol. 1989;125:53-56.
47. Saulsbury FT. Henoch-Schonlein purpura in children. Report of 100 patients and reviewof the literature. Medicine (Baltimore). 1999;78:395-409.
48. Masuda M, Nakanishi K, Yoshizawa N, et al. Group A streptococcal antigen in the glomeruli of children with Henoch-Schonlein nephritis. Am J Kidney Dis. 2003;41:366-370.
49. Novak J, Szekanecz Z, Sebesi J, et al. Elevated levels of anti-Helicobacter pylori antibodies in Henoch-Schonlein purpura. Autoimmunity. 2003;36:307-311.
50. Yang YH, Wang SJ, Chuang YH, et al. The level of IgA antibodies to human umbilical vein endothelial cells can be enhanced by TNF-alpha treatment in children with Henoch-Schonlein purpura. Clin Exp Immunol. 2002;130:352-357.
51. Ozaltin F, Bakkaloglu A, Ozen S, et al. The significance of IgA class of antineutrophil cytoplasmic antibodies (ANCA) in childhood Henoch-Schonlein purpura. Clin Rheumatol. 2004.
52. Rovel-Guitera P, Diemert MC, Charuel JL, et al. IgA antineutrophil cytoplasmic antibodies in cutaneous vasculitis. Br J Dermatol. 2000;143:99-103.
53. Burden AD, Tillman DM, Foley P, et al. IgA class anticardiolipin antibodies in cutaneous leukocytoclastic vasculitis. J Am Acad Dermatol. 1996;35:411-415.
54. Tancrede-Bohin E, Ochonisky S, Vignon-Pennamen MD, et al. Schonlein-Henoch purpura in adult patients. Predictive factors for IgA glomerulonephritis in a retrospective study of 57 cases. Arch Dermatol. 1997;133:438-442.
55. Van Hale HM, Gibson LE, Schroeter AL. Henoch-Schonlein vasculitis: direct immunofluorescence study of uninvolved skin. J Am Acad Dermatol. 1986;15:665-670.
56. Michel BA, Hunder GG, Bloch DA, et al. Hypersensitivity vasculitis and Henoch-Schonlein purpura: a comparison between the 2 disorders. J Rheumatol. 1992;19:721-728.
57. Sais G, Vidaller A. Role of direct immunofluorescence test in cutaneous leukocytoclastic vasculitis. Int J Dermatol. 2005;44:970-971.
58. Goldstein AR, White RH, Akuse R, et al. Long-term follow-up of childhood Henoch-Schonlein nephritis. Lancet. 1992;339:280-282.
59. Thervet E, Pillebout E, Guillevin L. Outcome after childhood Henoch-Schonlein purpura. Lancet. 2003;361:81.
60. Davin JC, Weening JJ. Diagnosis of Henoch-Schonlein purpura: renal or skin biopsy? Pediatr Nephrol. 2003;18:1201-1203.
61. Kawasaki Y, Suzuki J, Sakai N, et al. Clinical and pathological features of children with Henoch-Schoenlein purpura nephritis: risk factors associated with poor prognosis. Clin Nephrol. 2003;60:153-160.
62. Legrain V, Lejean S, Taieb A, et al. Infantile acute hemorrhagic edema of the skin: study of ten cases. J Am Acad Dermatol. 1991;24:17-22.
63. Goraya JS, Kaur S. Acute infantile hemorrhagic edema and Henoch-Schonlein purpura: is IgA the missing link? J Am Acad Dermatol. 2002;47:801.
64. Shah D, Goraya JS, Poddar B, et al. Acute infantile hemorrhagic edema and Henoch-Schonlein purpura overlap in a child. Pediatr Dermatol. 2002;19:92-93.
65. ten Holder SM, Joy MS, Falk RJ. Cutaneous and systemic manifestations of drug-induced vasculitis. Ann Pharmacother. 2002;36:130-147.
66. Jarrett SJ, Cunnane G, Conaghan PG, et al. Anti-tumor necrosis factor-alpha therapy-induced vasculitis: case series. J Rheumatol. 2003;30:2287-2291.
67. den Broeder AA, van den Hoogen FH, van de Putte LB. Isolated digital vasculitis in a patient with rheumatoid arthritis: good response to tumour necrosis factor alpha blocking treatment. Ann Rheum Dis. 2001;60:538-539.
68. Booth A, Harper L, Hammad T, et al. Prospective study of TNFalpha blockade with infliximab in anti-neutrophil cytoplasmic antibody-associated systemic vasculitis. J Am Soc Nephrol. 2004;15:717-721.
69. Mullick F, McSllister H, Wagner B, et al. Drug Related Vasculitis. Human Pathol. 1979;10:313-325.
70. Carlson JA, Mihm MC, Jr, LeBoit PE. Cutaneous lymphocytic vasculitis: a definition, a review, and a proposed classification. Semin Diagn Pathol. 1996;13:72-90.
71. Cuellar ML. Drug-induced vasculitis. Curr Rheumatol Rep. 2002;4:55-59.
72. Bahrami S, Malone JC, Webb KG, et al. Tissue eosinophilia as an indicator of drug-induced cutaneous small-vessel vasculitis. Arch Dermatol. 2006;142:155-161.
73. Somer T, Finegold SM. Vasculitides associated with infections, immunization, and antimicrobial drugs. Clin Infect Dis. 1995;20:1010-1036.
74. Guillevin L. Virus-associated vasculitides. Rheumatology (Oxford). 1999;38:588-590.
75. Rodriguez-Pla A, Stone JH. Vasculitis and systemic infections. Curr Opin Rheumatol. 2006;18:39-47.
76. Cohen P, Guillevin L. [Vasculitis associated with viral infections.]. Presse Med. 2004;33:1371-1384.
77. Aram G, Rohwedder A, Nazeer T, et al. Varicella-Zoster-Virus Folliculitis Promoted Clonal Cutaneous Lymphoid Hyperplasia. Am J Dermatopathol. 2005;27:411-417.
78. Garcia-Porrua C, Gonzalez-Gay MA. Bacterial infection presenting as cutaneous vasculitis in adults. Clin Exp Rheumatol. 1999;17:471-473.
79. Magro CM, Crowson AN. The cutaneous neutrophilic vascular injury syndromes: a review. Semin Diagn Pathol. 2001;18:47-58.
80. Plaut ME. Staphylococcal septicemia and pustular purpura. Report of cases. Arch Dermatol. 1969;99:82-85.
81. Chan HL. Bacterial infections of the skin. II: cutaneous clues to systemic infections. Ann Acad Med Singapore. 1983;12:98-102.
82. Ackerman AB, Miller RC, Shapiro L. Gonococcemia and Its Cutaneous Manifestations. Arch Dermatol. 1965;91:227-232.
83. Ackerman AB. Hemorrhagic bullae in gonococcemia. N Engl J Med. 1970;282:793-794.
84. Hill WR, Kinney TD. The cutaneous lesions in acute meningococcemia. A clinical and pathologic study. JAMA. 1947;134:513-518.
85. Shapiro L, Teisch JA, Brownstein MH. Dermatohistopathology of chronic gonococcal sepsis. Arch Dermatol. 1973;107:403-406.
86. Abu-Nassar H, Hill N, Fred HL, et al. Cutaneous Manifestations of Gonococcemia. A Review of 14 Cases. Arch Intern Med. 1963;112:731-737.
87. Scherer R, Braun-Falco O. Alternative pathway complement activation: A possible mechanism inducing skin lesions in benign gonococcal species. Br J Dermatol. 1976;95:303-309.
88. Sotto MN, Langer B, Hoshino-Shimizu S, et al. Pathogenesis of cutaneous lesions in acute meningococcemia in humans: light, immunofluorescent, and electron microscopic studies of skin biopsy specimens. J Infect Dis. 1976;133:506-514.
89. Fortin PR. Vasculitides associated with malignancy. Curr Opin Rheumatol. 1996;8:30-33.
90. Hutson TE, Hoffman GS. Temporal concurrence of vasculitis and cancer: a report of 12 cases. Arthritis Care Res. 2000;13:417-423.
91. Gonzalez-Gay MA, Garcia-Porrua C, Salvarani C, et al. Cutaneous vasculitis and cancer: a clinical approach. Clin Exp Rheumatol. 2000;18:305-307.
92. Wooten MD, Jasin HE. Vasculitis and lymphoproliferative diseases. Semin Arthritis Rheum. 1996;26:564-574.
93. Bachmeyer C, Wetterwald E, Aractingi S. Cutaneous vasculitis in the course of hematologic malignancies. Dermatology. 2005;210:8-14.
94. Jones D, Dorfman DM, Barnhill RL, et al. Leukemic vasculitis: a feature of leukemia cutis in some patients. Am J Clin Pathol. 1997;107:637-642.
95. Hunger RE, Durr C, Brand CU. Cutaneous leukocytoclastic vasculitis in dermatomyositis suggests malignancy. Dermatology. 2001;202:123-126.
96. Sangueza OP, Pilcher B, Martin Sangueza J. Erythema elevatum diutinum: a clinicopathological study of eight cases. Am J Dermatopathol. 1997;19:214-222.
97. Carlson JA, LeBoit PE. Localized chronic fibrosing vasculitis of the skin: an inflammatory reaction that occurs in settings other than erythema elevatum diutinum and granuloma faciale. Am J Surg Pathol. 1997;21:698-705.
98. Dowlati B, Firooz A, Dowlati Y. Granuloma faciale: successful treatment of nine cases with a combination of cryotherapy and intralesional corticosteroid injection. Int J Dermatol. 1997;36:548-551.
99. Smoller BR, McNutt NS, Contreras F. The natural history of vasculitis. What the histology tells us about pathogenesis. Arch Dermatol. 1990;126:84-89.
100. LeBoit PE, Yen TS, Wintroub B. The evolution of lesions in erythema elevatum diutinum. Am J Dermatopathol. 1986;8:392-402.
101. Ortonne N, Wechsler J, Bagot M, et al. Granuloma faciale: a clinicopathologic study of 66 patients. J Am Acad Dermatol. 2005;53:1002-1009.
102. Woody CM, Lane JE, Davis LS. Erythema elevatum diutinum in the setting of connective tissue disease and chronic bacterial infection. J Clin Rheumatol. 2005;11:98-104.
103. Wahl CE, Bouldin MB, Gibson LE. Erythema elevatum diutinum: clinical, histopathologic, and immunohistochemical characteristics of six patients. Am J Dermatopathol. 2005;27:397-400.
104. LeBoit PE, Cockerell CJ. Nodular lesions of erythema elevatum diutinum in patients infected with the human immunodeficiency virus. J Am Acad Dermatol. 1993;28:919-922.
105. Yiannias JA, el-Azhary RA, Gibson LE. Erythema elevatum diutinum: a clinical and histopathologic study of 13 patients. J Am Acad Dermatol. 1992;26:38-44.
106. Ayoub N, Charuel JL, Diemert MC, et al. Antineutrophil cytoplasmic antibodies of IgA class in neutrophilic dermatoses with emphasis on erythema elevatum diutinum. Arch Dermatol. 2004;140:931-936.
107. Radin DA, Mehregan DR. Granuloma faciale: distribution of the lesions and review of the literature. Cutis. 2003;72:213-219.
108. LeBoit PE. Granuloma faciale: a diagnosis deserving of dignity. Am J Dermatopathol. 2002;24:440-443.
109. Zirwas MJ, Abell E, Ruben A, et al. Immunofluorescence findings in granuloma faciale: report of two cases. J Cutan Pathol. 2003;30:314-317.
110. Nieboer C, Kalsbeek GL. Immunofluorescence studies in granuloma eosinophilicum faciale. J Cutan Pathol. 1978;5:68-75.
111. El Shabrawi-Caelen L, Kerl K, Cerroni L, et al. Cutaneous inflammatory pseudotumor-a spectrum of various diseases? J Cutan Pathol. 2004;31:605-611.
112. Thompson LD, Heffner DK. Sinonasal tract eosinophilic angiocentric fibrosis. A report of three cases. Am J Clin Pathol. 2001;115:243-248.
113. Devaney KO, Travis WD, Hoffman G, et al. Interpretation of head and neck biopsies in Wegener's granulomatosis. A pathologic study of 126 biopsies in 70 patients. Am J Surg Pathol. 1990;14:555-564.
114. Cacoub P, Costedoat-Chalumeau N, Lidove O, et al. Cryoglobulinemia vasculitis. Curr Opin Rheumatol. 2002;14:29-35.
115. Ferri C, Zignego AL, Giuggioli D, et al. HCV and cryoglobulinemic vasculitis. Cleve Clin J Med. 2002;69:SII20-SII23.
116. Gorevic PD, Kassab HJ, Levo Y, et al. Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients. Am J Med. 1980;69:287-308.
117. Sansonno D, Dammacco F. Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relations. Lancet Infect Dis. 2005;5:227-236.
118. Agnello V. Mixed cryoglobulinaemia after hepatitis C virus: more and less ambiguity. Ann Rheum Dis. 1998;57:701-702.
119. Cohen SJ, Pittelkow MR, Su WP. Cutaneous manifestations of cryoglobulinemia: clinical and histopathologic study of seventy-two patients. J Am Acad Dermatol. 1991;25:21-27.
120. Rieu V, Cohen P, Andre MH, et al. Characteristics and outcome of 49 patients with symptomatic cryoglobulinaemia. Rheumatology (Oxford). 2002;41:290-300.
121. Crowson AN, Nuovo G, Ferri C, et al. The dermatopathologic manifestations of hepatitis C infection: a clinical, histological, and molecular assessment of 35 cases. Hum Pathol. 2003;34:573-579.
122. Berliner S, Weinberger A, Ben-Bassat M, et al. Small skin blood vessel occlusions by cryoglobulin aggregates in ulcerative lesions in IgM-IgG cryoglobulinemia. J Cutan Pathol. 1982;9:96-103.
123. Popp JW, Jr, Harrist TJ, Dienstag JL, et al. Cutaneous vasculitis associated with acute and chronic hepatitis. Arch Intern Med. 1981;141:623-629.
124. Daoud MS, el-Azhary RA, Gibson LE, et al. Chronic hepatitis C, cryoglobulinemia, and cutaneous necrotizing vasculitis. Clinical, pathologic, and immunopathologic study of twelve patients. J Am Acad Dermatol. 1996;34:219-223.
125. Agnello V, Abel G. Localization of hepatitis C virus in cutaneous vasculitic lesions in patients with type II cryoglobulinemia. Arthritis Rheum. 1997;40:2007-2015.
126. Bernacchi E, Civita LL, Caproni M, et al. Hepatitis C virus (HCV) in cryoglobulinaemic leukocytoclastic vasculitis (LCV): could the presence of HCV in skin lesions be related to T CD8+ lymphocytes, HLA-DR and ICAM-1 expression? Exp Dermatol. 1999;8:480-486.
127. Feldman N, Hochberg M, Zizic T, et al. Cutaneous vasculitis in adult polymyositis/dermatomyositis. J Rheumatol. 1983;10:85-89.
128. Magro CM, Crowson AN, Regauer S. Mixed connective tissue disease. A clinical, histologic, and immunofluorescence study of eight cases. Am J Dermatopathol. 1997;19:206-213.
129. Toubi E, Kessel A, Bamberger E, et al. Systemic Lupus Erythematosus Vasculitis: A Current Therapeutic Overview. Curr Treat Options Cardiovasc Med. 2004;6:87-97.
130. Ramos-Casals M, Anaya JM, Garcia-Carrasco M, et al. Cutaneous vasculitis in primary Sjogren syndrome: classification and clinical significance of 52 patients. Medicine (Baltimore). 2004;83:96-106.
131. Cruickshank B. The arteritis of rheumatoid arthritis. Ann Rheum Dis. 1954;13:136-146.
132. Frances C, el Rassi R, Laporte JL, et al. Dermatologic manifestations of relapsing polychondritis. A study of 200 cases at a single center. Medicine (Baltimore). 2001;80:173-179.
133. Banker BQ, Victor M. Dermatomyositis (systemic angiopathy) of childhood. Medicine (Baltimore). 1966;45:261-289.
134. Luqmani RA, Pathare S, Kwok-Fai TL. How to diagnose and treat secondary forms of vasculitis. Best Pract Res Clin Rheumatol. 2005;19:321-336.
135. Kao AH, Sabatine JM, Manzi S. Update on vascular disease in systemic lupus erythematosus. Curr Opin Rheumatol. 2003;15:519-527.
136. Calamia KT, Balabanova M. Vasculitis in systemic lupus erythematosis. Clin Dermatol. 2004;22:148-156.
137. Bacon PA, Stevens RJ, Carruthers DM, et al. Accelerated atherogenesis in autoimmune rheumatic diseases. Autoimmun Rev. 2002;1:338-347.
138. Bacon PA. Endothelial cell dysfunction in systemic vasculitis: new developments and therapeutic prospects. Curr Opin Rheumatol. 2005;17:49-55.
139. Tomizawa K, Sato-Matsumura KC, Kajii N. The coexistence of cutaneous vasculitis and thrombosis in childhood-onset systemic lupus erythematosus with antiphospholipid antibodies. Br J Dermatol. 2003;149:439-441.
140. Rocca PV, Siegel LB, Cupps TR. The concomitant expression of vasculitis and coagulopathy: synergy for marked tissue ischemia. J Rheumatol. 1994;21:556-560.
141. Merkel PA, Polisson RP, Chang Y, et al. Prevalence of antineutrophil cytoplasmic antibodies in a large inception cohort of patients with connective tissue disease. Ann Intern Med. 1997;126:866-873.
142. Belmont HM, Abramson SB, Lie JT. Pathology and pathogenesis of vascular injury in systemic lupus erythematosus. Interactions of inflammatory cells and activated endothelium. Arthritis Rheum. 1996;39:9-22.
143. Drenkard C, Villa AR, Reyes E, et al. Vasculitis in systemic lupus erythematosus. Lupus. 1997;6:235-242.
144. Garcia-Carrasco M, Ramos-Casals M, Cervera R, et al. Cryoglobulinemia in systemic lupus erythematosus: prevalence and clinical characteristics in a series of 122 patients. Semin Arthritis Rheum. 2001;30:366-373.
145. Sontheimer RD, Thomas JR, Gilliam JN. Subacute cutaneous lupus erythematosus: a cutaneous marker for a distinct lupus erythematosus subset. Arch Dermatol. 1979;115:1409-1415.
146. Callen JP, Klein J. Subacute cutaneous lupus erythematosus. Clinical, serologic, immunogenetic, and therapeutic considerations in seventy-two patients. Arthritis Rheum. 1988;31:1007-1013.
147. Sanchez-Perez J, Penas PF, Rios-Buceta L, et al. Leukocytoclastic vasculitis in subacute cutaneous lupus erythematosus: clinicopathologic study of three cases and review of the literature. Dermatology. 1996;193:230-235.
148. Alarcon-Segovia D, Deleze M, Oria CV, et al. Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patients. Medicine (Baltimore). 1989;68:353-365.
149. Sanchez-Perez J, Fernandez-Herrera J, Sols M, et al. Leucocytoclastic vasculitis in subacute cutaneous lupus erythematosus. Br J Dermatol. 1993;128:469-470.
150. Callen JP, Kulick KB, Stelzer G, et al. Subacute cutaneous lupus erythematosus. Clinical, serologic, and immunogenetic studies of forty-nine patients seen in a nonreferral setting. J Am Acad Dermatol. 1986;15:1227-1237.
151. Hashimoto H, Maekawa S, Nasu H, et al. Systemic vascular lesions and prognosis in systemic lupus erythematosus. Scand J Rheumatol. 1984;13:45-55.
152. Yasue T. Livedoid vasculitis and central nervous system involvement in systemic lupus erythematosus. Arch Dermatol. 1986;122:66-70.
153. Mintz G, Fraga A. Arteritis in Systemic Lupus Erythematosus. Arch Intern Med. 1965;116:55-66.
154. Magro CM, Crowson AN, Harrist TJ. The use of antibody to C5b-9 in the subclassification of lupus erythematosus. Br J Dermatol. 1996;134:855-862.
155. Sayah A, English JC, 3rd. Rheumatoid arthritis: a review of the cutaneous manifestations. J Am Acad Dermatol. 2005;53:191-209.
156. Oien RF, Hakansson A, Hansen BU. Leg ulcers in patients with rheumatoid arthritis-a prospective study of aetiology, wound healing and pain reduction after pinch grafting. Rheumatology (Oxford). 2001;40:816-820.
157. Sokoloff L, Wilens SL, Bunim JJ. Arteritis of striated muscle in rheumatoid arthritis. Am J Pathol. 1951;27:157-173.
158. Bywaters EGL. Peripheral vascular obstruction in rheumatoid arthritis and its relationship to other vascular lesions. Ann Rheumatol Dis. 1957;16:84-103.
159. Westedt ML, Meijer CJ, Vermeer BJ, et al. Rheumatoid arthritis-the clinical significance of histo- and immunopathological abnormalities in normal skin. J Rheumatol. 1984;11:448-453.
160. Fitzgerald OM, Barnes L, Woods R, et al. Direct immunofluorescence of normal skin in rheumatoid arthritis. Br J Rheumatol. 1985;24:340-345.
161. Magro CM, Crowson AN. The spectrum of cutaneous lesions in rheumatoid arthritis: a clinical and pathological study of 43 patients. J Cutan Pathol. 2003;30:1-10.
162. Tsokos M, Lazarou SA, Moutsopoulos HM. Vasculitis in primary Sjogren's syndrome. Histologic classification and clinical presentation. Am J Clin Pathol. 1987;88:26-31.
163. Alexander E, Provost TT. Sjogren's syndrome. Association of cutaneous vasculitis with central nervous system disease. Arch Dermatol. 1987;123:801-810.
164. Chen KR, Kawahara Y, Miyakawa S, et al. Cutaneous vasculitis in Behcet's disease: a clinical and histopathologic study of 20 patients. J Am Acad Dermatol. 1997;36:689-696.
165. Lee KH, Chung HS, Bang D, et al. Behcet's disease sera containing antiendothelial cell antibodies promote adhesion of T lymphocytes to cultured human dermal microvascular endothelial cells. Yonsei Med J. 1999;40:152-158.
166. Kaklamani VG, Vaiopoulos G, Kaklamanis PG. Behcet's Disease. Semin Arthritis Rheum. 1998;27:197-217.
167. Levine JB, Lukawski-Trubish D. Extraintestinal considerations in inflammatory bowel disease. Gastroenterol Clin North Am. 1995;24:633-646.
168. Fernandes SR, Singsen BH, Hoffman GS. Sarcoidosis and systemic vasculitis. Semin Arthritis Rheum. 2000;30:33-46.
169. Irvine AD, Bruce IN, Walsh MY, et al. Microscopic polyangiitis. Delineation of a cutaneous-limited variant associated with antimyeloperoxidase autoantibody. Arch Dermatol. 1997;133:474-477.
170. Gibson LE, Specks U, Homburger H. Clinical utility of ANCA tests for the dermatologist. Int J Dermatol. 2003;42:859-869.
171. Sable-Fourtassou R, Cohen P, Mahr A, et al. Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome. Ann Intern Med. 2005;143:632-638.
172. Schmitt WH, van der Woude FJ. Clinical applications of antineutrophil cytoplasmic antibody testing. Curr Opin Rheumatol. 2004;16:9-17.
173. Sanders JS, Huitma MG, Kallenberg CG, et al. Prediction of relapses in PR3-ANCA-associated vasculitis by assessing responses of ANCA titres to treatment. Rheumatology (Oxford). 2006;45(6):724-729.
174. Vassilopoulos D, Niles JL, Villa-Forte A, et al. Prevalence of antineutrophil cytoplasmic antibodies in patients with various pulmonary diseases or multiorgan dysfunction. Arthritis Rheum. 2003;49:151-155.
175. Wilmoth GJ, Perniciaro C. Cutaneous extravascular necrotizing granuloma (Winkelmann granuloma): confirmation of the association with systemic disease. J Am Acad Dermatol. 1996;34:753-759.
176. Finan MC, Winkelmann RK. The cutaneous extravascular necrotizing granuloma (Churg-Strauss granuloma) and systemic disease: a review of 27 cases. Medicine (Baltimore). 1983;62:142-158.
177. Hamidou MA, Moreau A, Toquet C, et al. Temporal arteritis associated with systemic necrotizing vasculitis. J Rheumatol. 2003;30:2165-2169.
178. Genereau T, Lortholary O, Pottier MA, et al. Temporal artery biopsy: a diagnostic tool for systemic necrotizing vasculitis. French Vasculitis Study Group. Arthritis Rheum. 1999;42:2674-2681.
179. Chirinos JA, Tamariz LJ, Lopes G, et al. Large vessel involvement in ANCA-associated vasculitides: report of a case and review of the literature. Clin Rheumatol. 2004;23:152-159.
180. Weidner S, Hafezi-Rachti S, Rupprecht HD. Thromboembolic events as a complication of antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 2006;55:146-149.
181. Rees JD, Lanca S, Marques PV, et al. Prevalence of the antiphospholipid syndrome in primary systemic vasculitis. Ann Rheum Dis. 2006;65:109-111.
182. Lanham JG, Elkon KB, Pusey CD, et al. Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome. Medicine (Baltimore). 1984;63:65-81.
183. Abril A, Calamia KT, Cohen MD. The Churg Strauss Syndrome (allergic granulomatous angiitis): Review and update. Semin Arthritis Rheum. 2003;33:106-114.
184. Lhote F, Cohen P, Guillevin L. Polyarteritis nodosa, microscopic polyangiitis and Churg-Strauss syndrome. Lupus. 1998;7:238-258.
185. Guillevin L, Pagnoux C. When should immunosuppressants be prescribed to treat systemic vasculitides? Intern Med. 2003;42:313-317.
186. Della Rossa A, Baldini C, Tavoni A, et al. Churg-Strauss syndrome: clinical and serological features of 19 patients from a single Italian centre. Rheumatology (Oxford). 2002;41:1286-1294.
187. Guillevin L, Cohen P, Gayraud M, et al. Churg-Strauss syndrome. Clinical study and long-term follow-up of 96 patients. Medicine (Baltimore). 1999;78:26-37.
188. Churg A. Recent advances in the diagnosis of Churg-Strauss syndrome. Mod Pathol. 2001;14:1284-1293.
189. Mouthon L, Khaled M, Cohen P, et al. Antigen inhalation as a triggering factor in systemic small-sized-vessel vasculitis. Four cases. Ann Med Interne (Paris). 2001;152:152-156.
190. Kawakami T, Soma Y, Kawasaki K, et al. Initial cutaneous manifestations consistent with mononeuropathy multiplex in Churg-Strauss syndrome. Arch Dermatol. 2005;141:873-878.
191. Khan NA, Shenoy PK, McClymont L, et al. Exophthalmos and facial swelling: a case of limited Churg-Strauss syndrome. J Laryngol Otol. 1996;110:578-582.
192. Nissim F, Von der Valde J, Czernobilsky B. A limited form of Churg-Strauss syndrome: ocular and cutaneous manifestations. Arch Pathol Lab Med. 1982;106:305-307.
193. Chen KR, Ohata Y, Sakurai M, et al. Churg-Strauss syndrome: report of a case without preexisting asthma. J Dermatol. 1992;19:40-47.
194. English J, 3rd, Greer KE, McCrone SA, et al. Fluticasone-associated cutaneous allergic granulomatous vasculitis. J Drugs Dermatol. 2003;2:326-329.
195. Crotty CP, DeRemee RA, Winkelmann RK. Cutaneous clinicopathologic correlation of allergic granulomatosis. J Am Acad Dermatol. 1981;5:571-581.
196. Solans R, Bosch JA, Perez-Bocanegra C, et al. Churg-Strauss syndrome: outcome and long-term follow-up of 32 patients. Rheumatology (Oxford). 2001;40:763-771.
197. Chumbley LC, Harrison EG, Jr, DeRemee RA. Allergic granulomatosis and angiitis (Churg-Strauss syndrome). Report and analysis of 30 cases. Mayo Clin Proc. 1977;52:477-484.
198. Jennette JC, Thomas DB, Falk RJ. Microscopic polyangiitis (microscopic polyarteritis). Semin Diagn Pathol. 2001;18:3-13.
199. Guillevin L, Durand-Gasselin B, Cevallos R, et al. Microscopic polyangiitis: clinical and laboratory findings in eighty- five patients. Arthritis Rheum. 1999;42:421-430.
200. Bosch X. Microscopic polyangiitis (microscopic polyarteritis) with late emergence of generalised Wegener's granulomatosis. Ann Rheum Dis. 1999;58:644-647.
201. Peco-Antic A, Bonaci-Nikolic B, Basta-Jovanovic G, et al. Childhood microscopic polyangiitis associated with MPO-ANCA. Pediatr Nephrol. 2005.
202. Almoallim H, Caroline Patterson A. Microscopic polyangiitis sparing the kidneys in a long-term survivor after allogenic bone marrow transplantation and graft-versus-host disease. Clin Rheumatol. 2005;24:152-154.
203. Seishima M, Oyama Z, Oda M. Skin eruptions associated with microscopic polyangiitis. Eur J Dermatol. 2004;14:255-258.
204. Maejima H, Shirai K, Shimamura Y, et al. Microscopic polyangiitis presenting urticarial erythema and Henoch-Schonlein purpura: two case reports. J Dermatol. 2004;31:655-660.
205. Penas PF, Porras JI, Fraga J, et al. Microscopic polyangiitis. A systemic vasculitis with a positive P-ANCA. Br J Dermatol. 1996;134:542-547.
206. Akimoto S, Ishikawa O, Tsukada Y, et al. Microscopic polyangiitis mimicking Henoch-Schonlein purpura followed by severe renal involvement: a
207. Homas PB, David-Bajar KM, Fitzpatrick JE, et al. Microscopic polyarteritis. Report of a case with cutaneous involvement and antimyeloperoxidase antibodies. Arch Dermatol. 1992;128:1223-1228.
208. Irvine AD, Bruce IN, Walsh M, et al. Dermatological presentation of disease associated with antineutrophil cytoplasmic antibodies: a report of two contrasting cases and a review of the literature. Br J Dermatol. 1996;134:924-928.
209. Savage CO, Winearls CG, Evans DJ, et al. Microscopic polyarteritis: presentation, pathology and prognosis. Q J Med. 1985;56:467-483.
210. Lauque D, Cadranel J, Lazor R, et al. Microscopic polyangiitis with alveolar hemorrhage. A study of 29 cases and review of the literature. Medicine (Baltimore). 2000;79:222-233.
211. Rodgers H, Guthrie JA, Brownjohn AM, et al. Microscopic polyarteritis: clinical features and treatment. Postgrad Med J. 1989;65:515-518.
212. Hergesell OW, Andrassy K, Waldherr R, et al. Arteritis temporalis in a patient with microscopic polyangiitis. J Nephrol. 1997;10:30-32.
213. Langford CA. Wegener granulomatosis. Am J Med Sci. 2001;321:76-82.
214. Bajema IM, Hagen EC, van der Woude FJ, et al. Wegener's granulomatosis: a meta-analysis of 349 literary case reports. J Lab Clin Med. 1997;129:17-22.
215. Barksdale SK, Hallahan CW, Kerr GS, et al. Cutaneous pathology in Wegener's granulomatosis. A clinicopathologic study of 75 biopsies in 46 patients. Am J Surg Pathol. 1995;19:161-172.
216. Frances C, Du LT, Piette JC, et al. Wegener's granulomatosis. Dermatological manifestations in 75 cases with clinicopathologic correlation. Arch Dermatol 1994;130:861-867.
217. Patten SF, Tomecki KJ. Wegener's granulomatosis: cutaneous and oral mucosal disease. J Am Acad Dermatol. 1993;28:710-718.
218. Hu CH, O'Loughlin S, Winkelmann RK. Cutaneous manifestations of Wegener granulomatosis. Arch Dermatol. 1977;113:175-182.
219. Hoffman GS, Thomas-Golbanov CK, Chan J, et al. Treatment of subglottic stenosis, due to Wegener's granulomatosis, with intralesional corticosteroids and dilation. J Rheumatol. 2003;30:1017-1021.
220. Fauci AS, Haynes BF, Katz P, et al. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983;98:76-85.
221. Bacon PA. The spectrum of Wegener's granulomatosis and disease relapse. N Engl J Med. 2005;352:330-332.
222. Stone JH. Limited versus severe Wegener's granulomatosis: baseline data on patients in the Wegener's granulomatosis etanercept trial. Arthritis Rheum. 2003;48:2299-2309.
223. Brazzelli V, Vassallo C, Baldini F, et al. Wegener granulomatosis in a child: cutaneous findings as the presenting signs. Pediatr Dermatol. 1999;16:277-280.
224. Stein SL, Miller LC, Konnikov N. Wegener's granulomatosis: case report and literature review. Pediatr Dermatol. 1998;15:352-356.
225. Bull RH, Marsden RA, Cook MG, et al. Fatal facial ulceration. Clin Exp Dermatol. 1993;18:356-359.
226. Kubota T, Hirose H. Ocular changes in a limited form of Wegener's granulomatosis: patient with cutaneous ulcer of upper eyelid. Jpn J Ophthalmol. 2003;47:398-400.
227. Kuchel J, Lee S. Cutaneous Wegener's granulomatosis: a variant or atypical localized form? Australas J Dermatol. 2003;44:129-135.
228. Spigel GT, Krall RA, Hilal A. Limited Wegener's granulomatosis. Unusual cutaneous, radiographic, and pathologic manifestations. Cutis. 1983;32:41-44.
229. Kihiczak D, Nychay SG, Schwartz RA, et al. Protracted superficial Wegener's granulomatosis. J Am Acad Dermatol. 1994;30:863-866.
230. Figarella I, Bazarbachi T, Marie B, et al. [Cutaneous nodules recurring in the legs ten years before the diagnosis of Wegener's granulomatosis]. Rev Med Intern. 2000;21:693-697.
231. Foltz V, Koeger AC, de Sauverzac C, et al. Relapse of Wegener's granulomatosis. Concerning a case after 20 years of remission. Joint Bone Spine. 2001;68:262-266.
232. Hansen LS, Silverman S, Jr, Pons VG, et al. Limited Wegener's granulomatosis. Report of a case with oral, renal, and skin involvement. Oral Surg Oral Med Oral Pathol. 1985;60:524-531.
233. Abdou NI, Kullman GJ, Hoffman GS, et al. Wegener's granulomatosis: survey of 701 patients in North America. Changes in outcome in the 1990s. J Rheumatol. 2002;29:309-316.
234. Gibson LE, Daoud MS, Muller SA, et al. Malignant pyodermas revisited. Mayo Clin Proc. 1997;72:734-736.
235. Mangold MC, Callen JP. Cutaneous leukocytoclastic vasculitis associated with active Wegener's granulomatosis. J Am Acad Dermatol. 1992;26:579-584.
236. Hisler BM, Saltzman L. Cutaneous involvement in Wegener's granulomatosis. Cutis. 1991;48:460-461.
237. Handfield-Jones SE, Parker SC, Fenton DA, et al. Wegener's granulomatosis presenting as pyoderma gangrenosum. Clin Exp Dermatol. 1992;17:197-200.
238. Le Thi Huong DU, Wechsler B, Cabane J, et al. [Wegener's granulomatosis. Clinical aspects, nosologic problems. Review of the literature apropos of 30 cases]. Ann Med Interne (Paris). 1988;139:169-182.
239. Kouba DJ, Mimouni D, Ha CT, et al. Limited Wegener's granulomatosis manifesting as malignant pyoderma with corneal melt. Int J Dermatol. 2003;42:902-904.
240. Chyu JY, Hagstrom WJ, Soltani K, et al. Wegener's granulomatosis in childhood: cutaneous manifestations as the presenting signs. J Am Acad Dermatol. 1984;10:341-346.
241. Jacob SE, Martin LK, Kerdel FA. Cutaneous Wegener's granulomatosis (malignant pyoderma) in a patient with Crohn's disease. Int J Dermatol. 2003;42:896-898.
242. Kavanagh GM, Colaco CB, Bradfield JW, et al. Erythema elevatum diutinum associated with Wegener's granulomatosis and IgA paraproteinemia. J Am Acad Dermatol. 1993;28:846-849.
243. Nishino H, DeRemee RA, Rubino FA, et al. Wegener's granulomatosis associated with vasculitis of the temporal artery: report of five cases. Mayo Clin Proc. 1993;68:115-121.
244. Small P, Brisson ML. Wegener's granulomatosis presenting as temporal arteritis. Arthritis Rheum. 1991;34:220-223.
245. Palaic M, Yeadon C, Moore S, et al. Wegener's granulomatosis mimicking temporal arteritis. Neurology. 1991;41:1694-1695.
246. Gurses L, Yucelten D, Comert A, et al. Wegener's granulomatosis presenting as neutrophilic dermatosis: a case report. Br J Dermatol. 2000;143:207-209.
247. Burke AP, Virmani R. Localized vasculitis. Semin Diagn Pathol. 2001;18:59-66.
248. Shoda H, Kanda H, Tanaka R, et al. Wegener's granulomatosis with eosinophilia. Intern Med. 2005;44:750-753.
249. Yousem SA, Lombard CM. The eosinophilic variant of Wegener's granulomatosis. Hum Pathol. 1988;19:682-688.
250. Szocs HI, Torma K, Petrovicz E, et al. Wegener's granulomatosis presenting as pyoderma gangrenosum. Int J Dermatol. 2003;42:898-902.
251. Langford CA.15. Vasculitis. J Allergy Clin Immunol. 2003;111(2 Suppl):S602-S612.
252. Jennette JC, Falk RJ. Small-vessel vasculitis. N Engl J Med. 1997;337:1512-1523.
253. Fiorentino DF. Cutaneous vasculitis. J Am Acad Dermatol. 2003;48:311-340.
254. Diaz-Perez JL, Schroeter AL, Winkelmann RK. Cutaneous periarteritis nodosa: immunofluorescence studies. Arch Dermatol. 1980;116:56-58.