Economic analysis as a tool for process development: Harvest of a high cell-density

BioPharm International

Volumn 19, Issue 11, 2006, Pages 56-63

  Rathore, Anurag S ^a   Karpen, Matthew ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGICAL PROCEDURES; CELL DENSITY; COMMERCIAL PHENOMENA; DECISION MAKING; ECONOMIC ASPECT; PROCESS DEVELOPMENT; PROFIT; REVIEW;

EID: 33751325384     PISSN: 1542166X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (12)

1. Agres T. Better Future for Pharma/Biotech? Drug Disc Dev. 2002 Dec 15.
2. Curling J, Baines D. The cost of chromatography. IBC conference on Production and Economics of Biopharmaceuticals. 2000 Nov 13-15; La Jolla, CA
3. Rathore AS, Levine H, Latham P, Curling J, Kaltenbrunner, O. Costing Issues in Production of Biopharmaceuticals, BioPharm Int. 2004 Feb; 17(2):46-55.
4. Ernst S, Garro OA, Winkler S, Venkataraman G, Langer R, Cooney CL, et al. Process Simulation for Recombinant Protein Production: Cost Estimation and Sensitivity Analysis for Heparinase I Expressed in Escherichia coli, Biotechnol Bioeng. 1997; 53:575-582.
5. Sadana A, Beelaram AM. Efficiency and Economics of Bioseparation: Some Case Studies. Bioseparation. 1994; 4:221-235.
6. Warner TN, Nochumson S. Rethinking the Economics of Chromatography: New Technologies and Hidden Costs. BioPharm Int. 2003 Jan; 18(1): 58-60.
7. Novais JL, Titchener-Hookner NJ, Hoare M. Economic comparison between conventional and disposables-based technology for the production of biopharmaceuticals, Biotechnol Bioeng. 2001; 75:143-153.
8. Sinclair A, Monge M. Biomanufacturing for the 21st Century: Designing a Concept Facility Based on Single-Use Systems, BioProcess International. Part 1: 2004 Oct supp; 2-12;
9. Sinclair A, Monge M. BioProcess International. Part 2: 2005 Oct supp; 51-55.
10. Langer E, Ranck J. The ROI Case: Economic Justification for Disposables in Biopharmaceutical Manufacturing. BioProcess Int. 2005 Oct supp; 46-50.
11. Wang A, Lewus R, Rathore AS. Comparison of Different Options for Harvest of a Therapeutic Protein Product for High Cell Density Fermentation Broth. Biotechnol Bioeng. 2005;94:91-104.
12. Collentro A. Current Design Economics for USP Purified Water Generation Systems. Pharm Processing. 2004 Dec.