In vivo real-time vessel imaging and ex vivo 3D reconstruction of atherosclerotic plaque in apolipoprotein E-knockout mice using synchrotron radiation microscopy

International Journal of Cardiology

Volumn 114, Issue 2, 2007, Pages 166-171

  Kim, Jin Won ^a   Seo, Hong Seog ^a   Hwu, Y ^b   Je, Jung Ho ^c   Kim, Aeree ^a   Oh, Chilh Wan ^d   Suh, Soon Yong ^a   Rha, Seung Woon ^a   Park, Chang Gyu ^a   Oh, Dong Joo ^a  

^a Korea University College of Medicine   (South Korea)

^b INSTITUTE OF PHYSICS   (Taiwan)

^c Pohang University of Science and Technology (POSTECH)   (South Korea)

^d Korea University   (South Korea)

Author keywords

Apo E knockout mouse; Atherosclerosis; Plaque; Synchrotron; Unmonochromatized

Indexed keywords

APOLIPOPROTEIN E;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; DISSECTION; EX VIVO STUDY; HISTOPATHOLOGY; IMAGE RECONSTRUCTION; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MICROSCOPY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SYNCHROTRON RADIATION; THORACIC AORTA; WILD TYPE;

ANIMALS; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; IMAGING, THREE-DIMENSIONAL; MALE; MICE; MICE, KNOCKOUT; SYNCHROTRONS;

EID: 33751322954     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2005.12.010     Document Type: Article

References (10)

1. Momose A., Takeda T., and Itai Y. Blood vessels: depiction at phase contrast X-ray imaging without contrast agents in the mouse and rat: feasibility study. Radiology 217 (2000) 593-596
2. Momose A., Takeda T., and Itai Y. Contrast effect of blood on phase-contrast X-ray imaging. Acad Radiol 2 (1995) 883-887
3. Umetani K., Yagi N., Suzuki Y., Ogasawara Y., Kajiya F., and Matsumoto T. Observation and analysis of microcirculation using high spatial-resolution image detectors and synchrotron radiation. Proceedings of SPIE Physics of Medical Imaging vol. 3977 (2000) 522-533
4. Hwu Y., Tsai W.L., Chang H.M., et al. Imaging cells and tissues with refractive index radiology. Biophys J 87 (2004) 4180-4187
5. Seo H.S., Lombardi D.M., Polinsky P., et al. Peripheral vascular stenosis in apolipoprotein E deficient mice: potential roles of lipid deposition, medial atrophy, and adventitial inflammation. Arterioscler Thromb Vasc Biol 17 (1997) 3593-3601
6. Baik S., Kim H.S., Jeong M.H., et al. International consortium on phase contrast imaging and radiology beamline at the Pohang Light Source. Rev Sci Instrum 75 (2004) 4355-4358
7. Lee K.H., Hwu Y., Je J.H., et al. Synchrotron radiation imaging of internal structures in live animals. Yonsei Med J 43 1 (2002) 25-30
8. Hwu Y., Tsai W.-L., Groso A., and Margaritondo G. Coherence-enhanced synchrotron radiology: simple theory and practical applications. J. Appl. D, Appl. Phys. 35 (2002) R105-R120
9. Hwu Y., Tsai W.L., Je J.H., et al. Synchrotron microangiography with no contrast agent. Phys Med Biol 49 (2004) 501-508
10. Anastasio M.A., De Carlo F., and Pan X. Phase-contrast tomography and the local tomography problem. Proc SPIE 5030 (2003) 120-126