Ultrastructural morphometry of mammary gland in transgenic and non-transgenic rabbits

Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia

Volumn 35, Issue 6, 2006, Pages 351-356

  Dragin, S ^a,b,e   Pivko, J ^a,e   Massanyi, P ^c,e   Lukac, N ^c,e   Makarevich, A V ^a,e   Paleyanda, R K ^d,e   Chrenek, P ^a,e  

^a SLOVAK AGRICULTURAL RESEARCH CENTRE   (Slovakia)

^b University of Novi Sad   (Yugoslavia)

^c SLOVAK UNIVERSITY OF AGRICULTURE IN NITRA   (Slovakia)

^d American Integrated Biologics Inc   (United States)

^e RESEARCH INSTITUTE OF ANIMAL PRODUCTION   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

MILK PROTEIN; WHEY ACIDIC PROTEINS;

ANIMAL; ANIMAL DISEASE; ARTICLE; COMPARATIVE STUDY; CYTOLOGY; ELECTRON MICROSCOPY; FEMALE; GENETICS; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LACTATION; PATHOLOGY; RABBIT; TISSUE DISTRIBUTION; TRANSGENIC ANIMAL; UDDER; ULTRASTRUCTURE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; FEMALE; IMMUNOHISTOCHEMISTRY; LACTATION; MAMMARY GLANDS, ANIMAL; MICROSCOPY, ELECTRON; MILK PROTEINS; RABBITS; TISSUE DISTRIBUTION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33751322709     PISSN: 03402096     EISSN: 14390264     Source Type: Journal    
DOI: 10.1111/j.1439-0264.2006.00692.x     Document Type: Article

References (32)

1. Andres, A. C., M. A. van der Valk, C. A. Schonenberger, F. Fluckiger, M. LeMeur, P. Gerlinger, and B. Groner, 1988: Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice. Genes Dev. 2, 1486-1495.
2. Bischoff, R., E. Degryse, F. Perraud, W. Dalemans, D. Ali-Hadji, D. Thepot, E. Devinoy, L. M. Houdebine, and A. Pavirani, 1992: A 17.6 kbp region located upstream of the rabbit WAP gene directs high level expression of a functional human protein variant in transgenic mouse milk. FEBS Lett. 305, 265-268.
3. Boudreau, N., C. Myers, and M. J. Bissell, 1995: From laminin to lamin: regulation of tissue-specific gene expression by the ECM. Trends Cell Biol. 5, 1-4.
4. Chen, C. M., C. H. Wang, S. C. Wu, C. C. Lin, S. H. Lin, and W. T. K. Cheng, 2002: Temporal and spatial expression of biologically active human factor VIII in the milk of transgenic mice driven by mammary-specific bovine a-lactalbumin regulation sequences. Transgenic Res. 11, 257-268.
5. Chrenek, P, D. Vasicek, A. V. Makarevich, P. Uhrin, I. Petrovicova, H. Lubon, B. R. Binder, and J. Bulla, 2002: Integration and expression of the WAP-hPC gene in three generations of transgenic rabbits. Czech J. Anim. Sci. 47, 45-49.
6. Chrenek, P., D. Vasicek, A. V. Makarevich, R. Jurcik, K. Suvegova, M. Bauer, V. Parkanyi, J. Rafay, A. Batorova, and R. K. Paleyanda, 2005a: Increased transgene integration efficiency upon microinjection of DNA into both pronuclei of rabbit embryos. Transgenic Res. 14, 417-428.
7. Chrenek, P., V. Kaufmann, A. V. Makarevich, M. Bauer, L. Ryban, P. Uhrin, R. K. Paleyanda, and B. R. Binder, 2005b: Production of recombinant human clotting factor VIII in mammary gland of two transgenic rabbit lines. 49th GTH meeting in Mannheim, Germany, February, p. 118.
8. Christa, L., A. Pauloin, M. T. Simon, M. G. Stinnakre, M. L. Fontaine, S. Delpal, M. Ollivier-Bousquet, C. Brechot, and E. Devinoy, 2000: High expression of the human hepatocarcinoma-intestine-pancreas/pancreatic-associated protein (HIP/PAP) gene in the mammary gland of lactating transgenic mice. Secretion into the milk and purification of the HIP/PAP lectin. Eur. J. Biochem. 267, 1665-1671.
9. Devinoy, E., M. G. Stinnakre, F. Lavialle, D. Thepot, and M. Ollivier-Bousquet, 1995: Intracellular routing and release of caseins and growth hormone produced into milk from transgenic mice. Exp. Cell Res. 221, 272-280.
10. Dragin, S., 2003: Production and characteristics of transgenic rabbits. Master Sci. Thesis, Faculty of Agriculture Novi Sad, Serbia and Montenegro, 89 p.
11. Faraldo, M. M., M. A. Deugnier, S. Tlouzeau, J. P. Thiery, and M. A. Glukhova, 2002: Perturbation of beta1-integrin function in involuting mammary gland results in premature dedifferentiation of secretory epithelial cells. Mol. Biol. Cell 13, 3521-3531.
12. Hathaway, H. J., and B. D. Shur, 1996: Mammary gland morphogenesis is inhibited in transgenic mice that overexpress cell surface beta1,4- galactosyltransferase. Development 122, 2859-2872.
13. Hennighausen, L., G. W. Robinson, K. U. Wagner, and X. Liu, 1997: Developing a mammary gland is a stat affair. J. Mammary Gland Biol. Neoplasia 2, 365-372.
14. Jhappan, C., A. G. Geiser, E. C. Kordon, D. Bagheri, L. Hennighausen, A. B. Roberts, G. H. Smith, and G. Merlino, 1993: Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. EMBO J. 12, 1835-1845.
15. Massanyi, P., J. Slamecka, N. Lukac, and R. Jurcik, 2000: Seasonal variations in the morphometric analysis of the ovary and uterus and in progesterone and 17β-oestradiol production in the brown hare (Lepus europaeus). J. Anim. Feed Sci. 9, 697-708.
16. Massoud, M., J. Attal, D. Thepot, H. Pointu, M. G. . Stinnakre, M. C. Theron, C. Lopez, and L. M. Houdebine, 1996: The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits. Reprod. Nutr. Dev. 36, 555-563.
17. Morini, M., S. Astigiano, M. Mora, C. Ricotta, N. Ferrari, S. Mantero, G. Levi, M. Rossini, and O. Barbieri, 2000: Hyperplasia and impaired involution in the mammary gland of transgenic mice expressing human FGF4. Oncogene 19, 6007-6014.
18. Morroni, M., A. Giordano, M. C. Zingaretti, R. Boiani, R. De Matteis, B. B. Kahn, E. Nisoli, C. Tonello, C. Pisoschi, M. M. Luchetti, M. Marelli, and S. Cinti, 2004: Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland. Proc. Natl Acad. Sci. USA 101, 16801-16806.
19. Munarini, N., R. Jager, S. Abderhalden, G. Zuercher, V. Rohrbach, S. Loercher, B. Pfanner-Meyer, A. C. Andres, A. Ziemiecki, 2002: Altered mammary epithelial development, pattern formation and involution in transgenic mice expressing the EphB4 receptor tyrosine kinase. J. Cell Sci. 115, 25-37.
20. Nemir, M., D. Bhattacharyya, X. Li, K. Singh, A. B. Mukherjee, and B. B. Mukherjee, 2000: Targeted inhibition of osteopontin expression in the mammary gland causes abnormal morphogenesis and lactation deficiency. J. Biol. Chem. 275, 969-976.
21. Nukumi, N., K. Ikeda, M. Osawa, T. Iwamori, K. Naito, and H. Tojo, 2004: Regulatory function of whey acidic protein in the proliferation of mouse mammary epithelial cells in vivo and in vitro. Dev. Biol. 1, 31-44.
22. Paleyanda, R. K., D. W. Zhang, L. Hennighausen, R. A. McKnight, and H. Lubon, 1994: Regulation of human protein C gene expression by the mouse WAP promoter. Transgenic Res. 6, 335-343.
23. Paleyanda, R. K., W. H. Velander, T. K. Lee, D. H. Scandella, F. G. Gwazdauskas, J. W. Knight, L. W. Hoyer, W. N. Drohan, and H. Lubon, 1997a: Transgenic pigs produce functional human factor VIII in milk. Nat. Biotechnol. 15, 971-975.
24. Paleyanda, R. K., R. Drews, T. K. Lee, and H. Lubon, 1997b: Secretion of human furin into mouse milk. J. Biol. Chem. 272, 15270-15274.
25. Palmer, C. A., H. Lubon, and L. McManaman, 2003: Transgenic mice expressing recombinant human protein C exhibit defects in lactation and impaired mammary gland development. Transgenic Res. 12, 283-292.
26. Peaker, M., 1984: This symposium - with hindsight. In: Physiological Strategies in Lactation (M. Peaker, R. G. Vernon, and C. H. Knight, eds). London: Academic press, pp. XI-XIV.
27. Pollock, D. P., J. P. Kutzko, E. Birck-Wilson, J. L. Williams, Y. Echelard, and H. M. Meade, 1999: Transgenic milk as a method for the production of recombinant antibodies. J. Immunol. Methods 231, 147-157.
28. Robinson, G. W., G. H. Smith, D. Gallahan, A. Zimmer, P. A. Furth, and L. Hennighausen, 1996: Understanding mammary gland development through the imbalanced expression of growth regulators. Dev. Dyn. 206, 159-168.
29. Shamay, A., V. G. Pursel, E. Wilkinson, R. J. Wall, and L. Hennighausen, 1992: Expression of the whey acidic protein in the transgenic pigs impairs mammary development. Transgenic Res. 1, 124-132.
30. Stevens, A., and J. Lowe, 1992: Histology. London: Glover Medical Publishing, Mosby. Year Book Europe Ltd., pp. 378. ISBN 0-397-44633-0.
31. Van Cott, K. E., H. Lubon, C. G. Russell, S. P. Butler, F. C. Gwazdauskas, J. Knight, W. N. Drohan, and W. H. Velander, 1997: Phenotypic and genotypic stability of multiple lines of transgenic pigs expressing recombinant human protein C. Transgenic Res. 6, 203-212.
32. Weibel, E. R., G. S. Kistler, and W. F. Scherle, 1966: Practical stereological methods for morphometric cytology. J. Cell Biol. 30, 33-38.