Inhibition of sperm-egg binding and fertilisation in mice by a monoclonal antibody reactive to 57-kDa human sperm surface antigen

Reproduction, Fertility and Development

Volumn 18, Issue 8, 2006, Pages 875-884

  Reddy, K V R ^a   Vijayalaxmi, G ^a   Rajeev, K S ^a   Aranha, C ^a  

^a NATIONAL INSTITUTE FOR RESEARCH IN REPRODUCTIVE HEALTH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

FERTILITY ASSOCIATED SPERM ANTIGEN 57; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 3H4B9; SPERM ANTIGEN; UNCLASSIFIED DRUG;

ACROSOME REACTION; ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ANTIGEN PURIFICATION; CONFERENCE PAPER; DISEASE MARKER; DOSE RESPONSE; FEMALE; FERTILIZATION; HUMAN; HUMAN TISSUE; INHIBITION KINETICS; MALE; MOUSE; NONHUMAN; PROTEIN LOCALIZATION; SPERM EGG BINDING; SPERMATOGONIUM; TESTIS CELL; WESTERN BLOTTING;

ACROSOME; ACROSOME REACTION; ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; BRAIN; CRICETINAE; EPIDIDYMIS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; MACACA RADIATA; MALE; MEMBRANE PROTEINS; MESOCRICETUS; MICE; SPERM-OVUM INTERACTIONS; TESTIS;

MAMMALIA;

EID: 33751315297     PISSN: 10313613     EISSN: None     Source Type: Journal    
DOI: 10.1071/RD06028     Document Type: Conference Paper

References (50)

1. Basak, S., Dhar, R., and Das, C. (2002). Steroids modulate the expression of α4 integrin in mouse blastocysts and uterus during implantation. Biol. Reprod. 66, 1784-1789. doi:10.1095/ BIOLREPROD66.6.1784
2. Bellve, A. R., and Moss, S. B. (1983). Monoclonal antibodies as probe of reproductive mechanism. Biol. Reprod. 28, 1-26. doi:10.1095/BIOLREPROD28.1.1
3. Boettger, H., Richardson, D., and Free, D. (1989). Effects of in-vitro incubation on zona binding site found on murine spermatozoa. J. Exp. Zool. 249, 90-98. doi:10.1002/JEZ.1402490116
4. Bookbinder, L. H., Cheng, A., and Bleil, J. D. (1995). Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein. Science 269, 86-89.
5. Boue, F., Blais, J., and Sullivan, R. (1996). Surface localization of P34H, an epididymal protein, during maturation, capacitation and acrosome reaction of human spermatozoa. Biol. Reprod. 54, 1009-1017. doi:10.1095/ BIOLREPROD54.5.1009
6. Burks, D. J., Caerballada, R., and Moore, H. D. M. (1995). Interaction of a tyrosine kinase from human sperm with the zona pellucida at fertilization. Science 269, 83-86.
7. Chen, J. S., Concel, C. G., and Alvarez, C. (1995). Expression of mannose-binding sites on human spermatozoa and their role in sperm-zona pellucida binding. J. Androl. 16, 55-63.
8. Chennathukuzhi, V., Stein, J. M., and Abelt, J. (2003). Mice deficient for testis-brain RNA binding protein exhibt a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain and behavioral changes. Mol. Cell. Biol. 23, 6419-6434. doi:10.1128/MCB.23.18.6419-6434.2003
9. Clara, A., Manjramkar, D. D., and Reddy, K. V. R. (2004). Preclinical evaluation of magainin-A as a contraceptive antimicrobial agent. Fertil. Steril. 81, 1357-1365. doi:10.1016/J.FERTNSTERT. 2003.09.073
10. Domagala, A., and Kurpisz, M. (2004). Identification of sperm immunoreactive antigens for immunocontraceptive purposes: a review. Rep. Biol. Endocrinol. 2, 11. doi:10.1186/1477-7827-2-11
11. Dragatsis, I., Levine, M. S., and Zeitlin, S. (2000). In activation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nat. Genet. 26, 300-306. doi:10.1038/81593
12. Gaunt, S. J., Brown, C. R., and Jones, R. (1983). Identification of mobile and fixed antigens on the plasma membrane of rat spermatozoa using monoclonal antibodies. Exp. Cell Res. 144, 275-284. doi:10.1016/0014-4827(83) 90407-X
13. Hamatani, T., Tanabe, K., Kamei, K., Sakai, N., Yamamoto, Y., and Yoshimura, Y. (2000). A monoclonal antibody to human SP-10 inhibits in vitro binding of human sperm to hamster oolemma but not to human zona pellucida. Biol. Reprod. 62, 1201-1208. doi:10.1095/BIOLREPROD62.5.1201
14. Herr, J. C., Flickinger, C. J., Homy, K. M., Klotz, K., and John, E. (1990). Biochemical and morphological characterization of the intra-acrosomal antigen SP-10 from human sperm. Biol. Reprod. 42, 181-193. doi:10.1095/ BIOLREPROD42.1.181
15. Ilayperuma, I. (2002). Immunolocalization of guinea pig sperm surface antigen recognized by monoclonal antibody E74. Yale J. Biol. Med. 75, 47-53.
16. Isojima, S., Li, T. S., and Ashitaka, Y. (1968). Immunological analysis of sperm immobilizing factor found in the sera of women with unexplained sterility. Am. J. Obstet. Gynecol. 101, 677-683.
17. Jones, R., and Brown, C. R. (1987). Identification of zona binding protein from boar spermatozoa as proacrosin. Exp. Cell Res. 171, 503-508. doi:10.1016/0014-4827(87)90182-0
18. Jones, R., Shalgi, R., Holland, J., and Phillips, D. M. (1990). Topographical rearrangement of a plasma membrane antigen during capacitation of rat spermatozoa in vitro. Dev. Biol. 139, 349-362. doi:10.1016/0012-1606(90) 90304-2
19. Jorgensen, O. S., and Moller, M. (1983). A testis antigen related to the brain D2 adhesion protein. Dev. Biol. 100, 275-286. doi:10.1016/0012-1606(83) 90222-1
20. Katsh, S., and Katsh, G. F. (1965). A spermatogenic antigen from brain. Experimentia 21, 442-443. doi:10.1007/BF02150806
21. Klinefelter, G. R., Welche, J. E., and Perreault, S. D. (2002). Localization of the sperm protein SP22 and inhibition of fertility in vivo and in vitro. J. Androl. 23, 48-63.
22. Laemmli, U. K. (1970). Cleavage of structural proteins during assembly of the head of bacterophage T4. Nature 227, 680-685. doi:10.1038/227680A0
23. Lowry, O. H., Rosenbrough, N. J., and Farr, A. L. (1951). Protein measurement with folin phenol reagent. J. Biol. Chem. 193, 265-275.
24. McClure, R. D., Nunez, L., and Tom, R. (1989). Semen manipulation: improved sperm recovery and function with a two layer percoll gradient. Fertil. Steril. 51, 874-877.
25. Miller, D. I., Macek, M. B., and Shur, B. D. (1992). Complementarity between sperm surface β 1,4-galactosyltransferase and egg-coat ZP3 mediates sperm-egg binding in vitro. Nature 357, 589-593. doi:10.1038/357589A0
26. Moore, A., Penfold, L. M., and Johnson, J. L. (1993). Human sperm-egg binding is inhibited by peptides corresponding to core region of an acrosomal serine protease inhibitor. Mol. Reprod. Dev. 34, 280-291. doi:10.1002/MRD. 1080340308
27. Naz, R. K., and Ahmad, K. (1994). Molecular identities of human sperm proteins that bind human zona pellucida nature of spermzona interaction, tyrosine kinase activity and involvement of FA-1. Mol. Reprod. Dev. 39, 397-408. doi:10.1002/MRD.1080390408
28. Naz, R. K., Alexander, N. J., and Isahakia, M. (1984). Monoclonal antibody to a human germ cell membrane glycoprotein that inhibits fertilization. Science 225, 342-344.
29. Naz, R. K., Zhu, X., and Kadam, A. L. (2000). Identification of human sperm peptide sequence involved in egg binding for immunocontraception. Biol. Reprod. 62, 318-324. doi:10.1095/BIOLREPROD62.2.318
30. Nelson, L., Young, M. J., and Gardner, M. L. (1980). Sperm motility and calcium transport. A neurochemically controlled process. Life Sci. 26, 1739-1749. doi:10.1016/0024-3205(80)90573-1
31. Oi, V. T., and Herzenburg, L. A. (1980). Immunoglobulin producing hybrid cell lines. In 'Selected Methods in Cellular Immunology'. (Eds B. B. Mishell and S. M. Shiigi.) pp. 351-371. (Freeman Publisher: San Francisco, CA.)
32. O'Rand, M. G., Widgren, E. E., and Fisher, S. J. (1988). Characterization of the rabbit sperm membrane autoantigen, RSA, as a lectin-like zona binding protein. Dev. Biol. 129, 231-240. doi:10.1016/0012-1606(88)90177-7
33. Pires da Silva, A., Nayernia, K., Engel, W., Ttorres, M., Stoykova, A., Chowdhury, K., and Gruss, P. (2001). Mice deficient for spermatic pronuclear RNA binding protein show neurologic, spermatogenic and sperm morphological abnormalities. Dev. Biol. 233, 319-328. doi:10.1006/DBIO.2001.0169
34. Primakoff, P., and Myles, D. G. (1983). A map of the guinea pig sperm surface on structed with monoclonal antibodies. Dev. Biol. 98, 417-428. doi:10.1016/0012-1606(83)90371-8
35. Rajeev, S. K., and Reddy, K. V. R. (2004). Sperm membrane protein profiles of fertile and infertile men: Identification and characterization of fertility associated sperm antigen. Hum. Reprod. 19, 234-242. doi:10.1093/HUMREP/DEH066
36. Reddy, K. V. R., and Manjramkar, D. (2000). Evaluation of anti-fertility effect of magainin peptide in rabbits: an in-vivo study. Fertil. Steril. 73, 353-358. doi:10.1016/S0015-0282(99)00499-9
37. Reddy, K. V. R., Meherji, P. K., and Sahani, S. K. (1998). Integrin cell adhesion molecules on human spermatozoa. Ind. J. Exp. Biol. 36, 450-463.
38. Reddy, K. V. R., Rajeev, S. K., and Vijayalaxmi, G. (2003). α6β1 integrin is a clinical marker to evaluate the sperm quality in men. Fertil. Steril. 79, 1590-1596. doi:10.1016/S0015-0282(03)00368-6
39. Reynolds, A. L. B., and Oliphant, G. (1984). Production and characterization of monoclonal antibodies to the sperm acrosome stabilizing factor (ASF): utilization for purification and molecular analysis of ASF. Biol. Reprod. 30, 775-786. doi:10.1095/BIOLREPROD30.3.775
40. Saling, P. M., and Lakoski, K. A. (1985). Mouse sperm antigens that participate in fertilization. II. Inhibition of sperm penetration through the zona pellucida using monoclonal antibodies. Biol. Reprod. 33, 527-536. doi:10.1095/BIOLREPROD33.2.527
41. Sanz, L., Cavete, J. J., and Man, K. (1992). The complete primary structure of the sperm adhesion AWN, a zona pellucida binding protein isolated from boar spermatozoa. FEBS Lett. 300, 213-218. doi:10.1016/0014-5793(92)80848-B
42. Sathasivam, K., Hobbs, C., Turmaine, M., Mangiarini, L., Mahal, A., Bertaux, F., Wanker, E. E., Doherty, P., Davies, S. W., and Bates, G. P. (1999). Formation of polyglutamine inclusions in non-CNS tissues. Hum. Mol. Genet. 8, 813-822. doi:10.1093/HMG/8.5.813
43. Saxena, D. K., and Toshimori, K. (2004). Molecular modifications of MC31/CE9, a sperm surface molecule, during sperm capacitation and the acrosome reaction in the rat: is MC31/CE9 required for fertilization? Biol. Reprod. 70, 993-1000. doi:10.1095/ BIOLREPROD.103.021667
44. Sharp, A. H., Loev, S. J., Schilling, G., Li, S. H., Li, X. J., et al. (1995). Widespread expression of Huntington's disease gene protein product. Neuron 14, 1065-1074. doi:10.1016/0896-6273(95)90345-3
45. Shetty, J., Naaby-Hansen, S., and Shibahara, H. (1999). Human sperm proteome: immunodominant sperm surface antigens identified with sera from infertile men and women. Biol. Reprod. 61, 61-69. doi:10.1095/BIOLREPROD61.1.61
46. Tanphaichitr, N., Smith, J., and Mongkolsirkieart, S. (1993). Role of a gamete specific sulfoglycolipid-immobilising protein on mouse sperm-egg binding. Dev. Biol. 156, 164-175. doi:10.1006/ DBIO.1993.1067
47. Towbin, H., Staehelin, T., and Gordon, T. J. (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. USA 76, 4350-4354. doi:10.1073/PNAS.76.9.4350
48. Wheat, T. E., and Goldberg, E. (1984). Isolation of the sperm specific lactate dehydrogenase from mouse, rabbit and human testes and human spermatozoa. In 'Immunological Influences on Human Fertility'. (Ed. B. Boettcher.) pp. 221-227. (Academic Press: New York.)
49. Wolf, D. E., McKinnon, C. A., Leyton, L., Loveland, K. L., and Sailing, P. M. (1992). Protein dynamics in sperm membranes: implications for sperm function during gamete interaction. Mol. Reprod. Dev. 33, 228-234. doi:10.1002/MRD.1080330217
50. World Health Organization (1992). 'WHO Laboratory Manual for the Examination of Human Semen Cervical Mucus Interactions.' 3rd edn. (Cambridge University Press: London.)