Expression and regulatory role of GAIP-interacting protein GIPC in pancreatic adenocarcinoma

Cancer Research

Volumn 66, Issue 21, 2006, Pages 10264-10268

  Muders, Michael H ^a   Dutta, Shamit K ^a   Wang, Ling ^a   Lau, Julie S ^a   Bhattacharya, Resham ^a   Smyrk, Thomas C ^b   Chari, Suresh T ^b   Datta, Kaustubh ^a   Mukhopadhyay, Debabrata ^a,c  

^a MAYO CLINIC CANCER CENTER   (United States)

^b Mayo Clinic   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN GAIP; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RNA INTERFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOCARCINOMA; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOPLASM; HUMANS; PANCREATIC NEOPLASMS; RECEPTOR, IGF TYPE 1; RNA, MESSENGER; TISSUE ARRAY ANALYSIS;

EID: 33751287963     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-2321     Document Type: Article

References (18)

1. Bardeesy N, DePinho RA. Pancreatic cancer biology and genetics. Nat Rev Cancer 2002;2:897-909.
2. Larsson O, Girnita A, Girnita L. Role of insulin-like growth factor 1 receptor signalling in cancer. Br J Cancer 2005;92:2097-101.
3. Booth RA, Cummings C, Tiberi M, et al. GIPC participates in G protein signaling downstream of insulin-like growth factor 1 receptor. J Biol Chem 2002;277:6719-25.
4. Ligensa T, Krauss S, Demuth D, et al. A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor. J Biol Chem 2001;276:33419-27.
5. Aschenbrenner L, Lee T, Hasson T. Myo6 facilitates the translocation of endocytic vesicles from cell peripheries. Mol Biol Cell 2003;14:2728-43.
6. Lou X, McQuistan T, Orlando RA, et al. GAIP, GIPC, and Gαi3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. J Am Soc Nephrol 2002;13:918-27.
7. Wang L, Mukhopadhyay D, Xu X. C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis. FASEB J 2006;20:1513-5.
8. De Vries L, Lou X, Zhao G, et al. GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proc Natl Acad Sci U S A 1998;95:12340-5.
9. Kirikoshi H, Katoh M. Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors. Int J Mol Med 2002;9:509-13.
10. Zeng H, Datta K, Neid M, et al. Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line. Biochem Biophys Res Commun 2003;302:46-55.
11. Neid M, Datta K, Stephan S, et al. Role of insulin receptor substrates and protein kinase C-ζ in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells. J Biol Chem 2004;279:3941-8.
12. Nair PN, De Armond DT, Adamo ML, et al. Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-IR) are mediated by an induction of IGF-IR promoter activity and stabilization of IGF-IR mRNA and contributes to growth factor independence and increased survival of the pancreatic cancer cell line MIA PaCa-2. Oncogene 2001;20:8203-14.
13. Dance AL, Miller M, Seragaki S, et al. Regulation of myosin-VI targeting to endocytic compartments. Traffic 2004;5:798-813.
14. Hasson T. Myosin VI: two distinct roles in endocytosis. J Cell Sci 2003;116:3453-61.
15. Lou X, Yano H, Lee F, et al. GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. Mol Biol Cell 2001;12:615-27.
16. 6 subunits. Matrix Biol 2002;21:207-14.
17. Woods DF, Bryant PJ. The discs-large tumor suppressor gene of Drosphila encodes a guanylate kinase homolog localized at septate junctions. Cell 1991;66:451-64.
18. Naccache SN, Hasson T, Horowitz A. Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles. Proc Natl Acad Sci U S A 2006;103:12735-40.