α(1D)-adrenoceptors do not contribute to inotropic responses of neonatal rat myocardium

Journal of Cardiovascular Pharmacology

Volumn 29, Issue 1, 1997, Pages 57-60

  Deng, Xing Fei ^a   Varma, Daya R ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

5 Methylurapidil; 3H Prazosin binding; Aortic (1D) adrenoceptors; BMY 7378; Cerebral (1D) adrenoceptors; Inotropic effects; Myocardial (1D) adrenoceptors; Phenylephrine

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 5 METHYLURAPIDIL; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1D ADRENERGIC RECEPTOR; CHLOROETHYLCLONIDINE; NIGULDIPINE; PHENYLEPHRINE; PRAZOSIN;

ANIMAL TISSUE; AORTA STRIP; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG INHIBITION; DRUG RECEPTOR BINDING; HEART MUSCLE CONTRACTILITY; INOTROPISM; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANIMALS, NEWBORN; AORTA; CELL MEMBRANE; CEREBRAL CORTEX; HEART VENTRICLES; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL CONTRACTION; MYOCARDIUM; PHENYLEPHRINE; PIPERAZINES; PRAZOSIN; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; VASOCONSTRICTOR AGENTS;

EID: 0004434264     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199701000-00009     Document Type: Article

References (16)

1. 1-adrenoceptors: consensus update. Pharmacol Rev 1995;47:267-70.
2. 1-adrenoceptors: an overview. Pharmacol Rev 1993;45:147-75.
3. 1-adrenergic receptor subtype classification. Mol Pharmacol 1994;46: 221-6.
4. Scofield MA, Liu F, Abel PW, Jefferies WB. Quantification of steady state expression of mRNA for alpha-1 adrenergic receptor subtypes using reverse transcription and a competitive polymerase chain reaction. J Pharmacol Exp Ther 1995;275:1035-42.
5. 1D mRNAs are present in cardiac myocytes but not in cardiac fibroblasts. Circ Res 1994;75:796-802.
6. Deng XF, Chemtob S, Almazan G, Varma DR. Ontogenic differences in the functions of myocardial alpha 1-adrenoceptor subtypes in rats. J Pharmacol Exp Ther 1996;276:1155-61.
7. 1-adrenoceptors. Eur J Pharmacol 1995;272:R5-6.
8. 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline. Br J Pharmacol 1995;115:981-6.
9. Piascik MT, Guarino RD, Smith MS, Soltis EE, Saussy DL, Perez DM. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J Pharmacol Exp Ther 1995;275:1583-9.
10. 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta. Life Sci 1995;57:PL159-63.
11. Jagadeesh G & Deth RC. Different affinity states of alpha-1 adrenergic receptors defined by agonists and antagonists in bovine aorta plasma membrane. J Pharmacol Exp Ther 1987;243:430-6.
12. 50) of an enzyme reaction. Biochem Pharmacol 1973; 22:3099-108.
13. Rokosh DG, Bailey BA, Stewart AFR, Karns LR, Long CS, Simpson PC Distribution of α1C-adrenergic receptor mRNA in adult rat tissues by RNase protection assay and comparison with α1B and α1D. Biochem Biophys Res Commun 1994;200:1177-84.
14. 1-adrenergic receptor subtypes modulate catecholamine-induced increases and decreases in ventricular automaticity. Circ Res 1990;67:1535-51.
15. 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem 1993;268:15374-80.
16. Fujinaga M, Hu ZW, Okazaki M, Baden JM, Koffman BB. Expression of mRNA for alpha-1-adrenoceptor subtypes at the beginning of neurulation in rat embryos. Toxicol in Vitro 1995;9:601-6.