Induction of labor at term using isosorbide mononitrate simultaneously with dinoprostone compared to dinoprostone treatment alone: A randomized, controlled trial

American Journal of Obstetrics and Gynecology

Volumn 195, Issue 6, 2006, Pages 1617-1622

  Wölfler, Monika M ^a,b   Facchinetti, Fabio ^c   Venturini, Paolo ^c   Huber, Ambros ^a   Helmer, Hanns ^a   Husslein, Peter ^a   Tschugguel, Walter ^a  

^a UNIV KLIN FÜR FRAUENHEILKUNDE   (Austria)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Cervical ripening; Isosorbide mononitrate; Labor induction; Nitric oxide; Term pregnancy

Indexed keywords

ISOSORBIDE MONONITRATE; PROSTAGLANDIN E2;

ADULT; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG INDUCED HEADACHE; FEMALE; HUMAN; LABOR INDUCTION; MAJOR CLINICAL STUDY; MONOTHERAPY; MULTICENTER STUDY; NULLIPARA; PREGNANCY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UTERUS RELAXATION;

ADMINISTRATION, INTRAVAGINAL; ADULT; DELIVERY, OBSTETRIC; DINOPROSTONE; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HEADACHE; HUMANS; ISOSORBIDE DINITRATE; LABOR, INDUCED; OXYTOCICS; PREGNANCY; TIME FACTORS;

EID: 33751248217     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2006.03.096     Document Type: Article

References (25)

1. Kelly A.J., Kavanagh J., and Thomas J. Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term. Cochrane Database Syst Rev (2003) CD003101
2. Kelly A.J., and Tan B. Intravenous oxytocin alone for cervical ripening and induction of labour. Cochrane Database Syst Rev (2001) CD003246
3. Thomas J., Kelly A.J., and Kavanagh J. Oestrogens alone or with amniotomy for cervical ripening or induction of labour. Cochrane Database Syst Rev (2001) CD003393
4. Kelly A.J., Kavanagh J., and Thomas J. Relaxin for cervical ripening and induction of labour. Cochrane Database Syst Rev (2001) CD003103
5. Chwalisz K., Shao-Qing S., Garfield R.E., and Beier H.M. Cervical ripening in guinea-pigs after a local application of nitric oxide. Hum Reprod 12 (1997) 2093-2101
6. Tschugguel W., Schneeberger C., Lass H., Stonek F., Zaglula M.B., Czerwenka K., et al. Human cervical ripening is associated with an increase in cervical inducible nitric oxide synthase expression. Biol Reprod 60 (1999) 1367-1372
7. Thomson A.J., Lunan C.B., Ledingham M., Howart R.C., Cameron I.T., Greer I.A., et al. Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy. Lancet 352 (1998) 1093-1096
8. Facchinetti F., Piccinini F., and Volpe A. Chemical ripening of the cervix with intracervical application of sodium nitroprusside: a randomized controlled trial. Hum Reprod 15 (2000) 2224-2227
9. Li C.F., Chan C.W., and Ho P.C. A study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancy. Contraception 68 (2003) 269-272
10. Eppel W., Facchinetti F., Schleussner E., Pizzi C., Gruber D.M., Schneider B., et al. Second trimester abortion using isosorbide mononitrate in addition to gemeprost compared with gemeprost alone: a double-blind randomized, placebo-controlled multicenter trial. Am J Obstet Gynecol 192 (2005) 856-861
11. Lees C., Campbell S., Jauniaux E., Brown R., Ramsay B., Gibb D., et al. Arrest of preterm labour and prolongation of gestation with glyceryl trinitrate, a nitric oxide donor. Lancet 343 (1994) 1325-1326
12. Nicoll A.E., Mackenzie F., Greer I.A., and Norman J.E. Vaginal application of the nitric oxide donor isosorbide mononitrate for preinduction cervical ripening: a randomized controlled trial to determine effects on maternal and fetal hemodynamics. Am J Obstet Gynecol 184 (2001) 958-964
13. Chanrachakul B., Herabutya Y., and Punyavachira P. Randomized comparison of glyceryl trinitrate and prostaglandin E2 for cervical ripening at term. Obstet Gynecol 96 (2000) 549-553
14. Chanrachakul B., Herabutya Y., and Punyavachira P. Randomized trial of isosorbide mononitrate versus misoprostol for cervical ripening at term. Int J Gynaecol Obstet 78 (2002) 139-145
15. Sharma Y.K.S., Mittal S., Misra R., and Dadhwal V. Evaluation of glyceryl trinitrate, misoprostol, and prostaglandin E2 gel for preinduction cervical ripening in term pregnancy. J Obstet Gynaecol Res 31 (2005) 210-215
16. Ekerhovd E., Bullarbo M., Andersch B., and Norstrom A. Vaginal administration of the nitric oxide donor isosorbide mononitrate for cervical ripening at term: a randomized controlled study. Am J Obstet Gynecol 189 (2003) 1692-1697
17. Garfield R.E., Saade G., Buhimschi C., Buhimschi I., Shi S.Q., and Chwalisz K. Control and assessment of the uterus and cervix during pregnancy and labour. Hum Reprod Update 4 (1998) 673-695
18. Maul H., Longo M., Saade G.R., and Garfield R.E. Nitric oxide and its role during pregnancy: from ovulation to delivery. Curr Pharm Des 9 (2003) 359-380
19. Chwalisz K., and Garfield R.E. Regulation of the uterus and cervix during pregnancy and labor. Role of progesterone and nitric oxide. Ann N Y Acad Sci 828 (1997) 238-253
20. Ledingham M.A., Thomson A.J., Young A., Macara L.M., Greer I.A., and Norman J.E. Changes in the expression of nitric oxide synthase in the human uterine cervix during pregnancy and parturition. Mol Hum Reprod 6 (2000) 1041-1048
21. Tornblom S.A., Maul H., Klimaviciute A., Garfield R.E., Bystrom B., Malmstrom A., et al. mRNA expression and localization of bNOS, eNOS and iNOS in human cervix at preterm and term labour. Reprod Biol Endocrinol 3 (2005) 33
22. Bates C.D., Nicoll A.E., Mullen A.B., Mackenzie F., Thomson A.J., and Norman J.E. Serum profile of isosorbide mononitrate after vaginal administration in the third trimester. BJOG 110 (2003) 64-67
23. Abshagen U.W. Pharmacokinetics of isosorbide mononitrate. Am J Cardiol 70 (1992) 61G-66G
24. Bulletti C., de Ziegler D., Flamigni C., Giacomucci E., Polli V., Bolelli G., et al. Targeted drug delivery in gynaecology: the first uterine pass effect. Hum Reprod 12 (1997) 1073-1079
25. Bulletti C., de Ziegler D., de Moustier B., Polli V., Bolelli G., Franceschetti F., et al. Uterine contractility: vaginal administration of the beta-adrenergic agonist, terbutaline. Evidence of direct vagina-to-uterus transport. Ann N Y Acad Sci 943 (2001) 163-171