Second trimester abortion using isosorbide mononitrate in addition to gemeprost compared with gemeprost alone: A double-blind randomized, placebo-controlled multicenter trial

American Journal of Obstetrics and Gynecology

Volumn 192, Issue 3, 2005, Pages 856-861

  Eppel, Wolfgang ^a   Facchinetti, Fabio ^c   Schleussner, Ekkehard ^d   Piccinini, Federica ^c   Pizzi, Cristina ^c   Gruber, Doris M ^a   Schneider, Barbara ^b   Tschugguel, Walter ^a  

^a UNIV KLIN FÜR FRAUENHEILKUNDE   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Abortion; Gemeprost; Isosorbide mononitrate; Second trimester

Indexed keywords

GEMEPROST; ISOSORBIDE MONONITRATE; PLACEBO;

ABDOMINAL PAIN; ADD ON THERAPY; ADULT; CLINICAL TRIAL; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; FEMALE; GESTATIONAL AGE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MONOTHERAPY; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; NAUSEA; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SECOND TRIMESTER ABORTION; VAGINA BLEEDING; VOMITING;

EID: 14644420227     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2004.10.597     Document Type: Conference Paper

References (15)

1. S.M.M. Karim Termination of second trimester pregnancy with prostaglandins S.M.M. Karim Practical applications of prostaglandins and their synthesis inhibitors 1979 MTP Press Philadelphia 375 409
2. L. Sanchez-Ramos, and E. Hsieh Pharmacologic methods for cervical ripening and labor induction Curr Womens Health Rep 31 2003 55 60
3. W.F. Rayburn Preinduction cervical ripening: basis and methods of current practice Obstet Gynecol Surv 57 2002 683 692
4. R.C. Henshaw, and A.A. Templeton Pre-operative cervical preparation before first trimester vacuum aspiration: a randomized controlled comparison between gemeprost and mifepristone (RU 486) BJOG 98 1991 1025 1030
5. A.J. Thomson, C.B. Lunan, A.D. Cameron, I.T. Cameron, I.A. Greer, and J.E. Norman Nitric oxide donors induce ripening of the human uterine cervix: a randomised controlled trial BJOG 104 1997 1054 1057
6. F. Facchinetti, F. Piccinini, and A. Volpe Chemical ripening of the cervix with intracervical application of sodium nitroprusside: a randomized controlled trial Hum. Reprod 15 2000 2224 2227
7. A.J. Thomson, C.B. Lunan, M. Ledingham, R.C. Howat, I.T. Cameron, and I.A. Greer Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy Lancet 352 1998 1093 1096
8. M.A. Ledingham, F.C. Denison, R.W. Kelly, A. Young, and J.E. Norman Nitric oxide donors stimulate prostaglandin F (2 alpha) and inhibit thromboxane B (2) production in the human cervix during the first trimester of pregnancy Mol Hum Reprod 5 1999 973 982
9. E. Ekerhovd, B. Weijdegard, M. Brannstrom, I. Mattsby-Baltzer, and A. Norstrom Nitric oxide induced cervical ripening in the human: involvement of cyclic guanosine monophosphate, prostaglandin F (2 alpha), and prostaglandin E (2) Am J Obstet Gynecol 186 2002 745 750
10. R.E. Garfield, G. Saade, C. Buhimschi, I. Buhimschi, L. Shi, and K. Chwalisz Control and assessment of the uterus and cervix during pregnancy and labour Hum Reprod Update 4 1998 673 695
11. M. Bygdeman Pharmacokinetics of prostaglandins Best Pract Res Clin Obstet Gynaecol 17 2003 707 716
12. F. Facchinetti, A. Gandolfi, M. Longo, and A. Volpe Serum nitrites predict the response to prostaglandin-induced delivery at term J Soc Gynecol Invest 5 1998 140 143
13. C.I. Li, C.C. Chan, and P. Ho A study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancy Contraception 68 2003 269 272
14. M. Ledingham, A.J. Thomson, C.B. Lunan, I.A. Greer, and J.E. Norman A comparison of isosorbide mononitrate, misoprostol and combination therapy for first trimester pre-operative cervical ripening: a randomised controlled trial BJOG 108 2001 276 280
15. J.E. Norman, K.J. Thong, and D.T. Baird Uterine contractility and induction of abortion in early pregnancy by misoprostol and mifepristone Lancet 338 1991 1233 1236