Genetic aspects of restless legs syndrome

Postgraduate Medical Journal

Volumn 82, Issue 972, 2006, Pages 626-629

  Dhawan, V ^a   Ali, M ^b   Chaudhuri, K R ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME 12Q; CHROMOSOME 14Q; CHROMOSOME 9Q; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; HEREDITY; HUMAN; INHERITANCE; IRON DEFICIENCY ANEMIA; LINKAGE ANALYSIS; PATHOGENESIS; PATHOPHYSIOLOGY; PERIPHERAL NEUROPATHY; PHENOTYPIC VARIATION; PREVALENCE; RESTLESS LEGS SYNDROME; REVIEW; SPINOCEREBELLAR DEGENERATION; UREMIA;

CHROMOSOME MAPPING; FORECASTING; HUMANS; LINKAGE (GENETICS); PEDIGREE; RESTLESS LEGS SYNDROME; SPINOCEREBELLAR ATAXIAS;

EID: 33751243355     PISSN: 00325473     EISSN: None     Source Type: Journal    
DOI: 10.1136/pgmj.2006.045690     Document Type: Review

References (30)

1. Walters AS, LeBrocq C, Dhar A, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 2003;4:133-5.
2. Allen RP, Kushida CA, Atkinson MJ. Factor analysis of the International Restless Legs Syndrome Study Group's scale for restless legs severity. Sleep Med 2003;4:133-5.3.
3. Allen RP, Picchietti D, Hening WA, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the Restless Legs Syndrome Diagnosis and Epidemiology Workshop at the National Institutes of Health. Sleep Med 2003;4:101-19.
4. Oppenheim H. Lehbuch der Nervenkrankheiten, 7th edn. Berlin: Karger, 1923:1774.
5. Chaudhuri KR. The restless legs syndrome: time to recognise a very common movement disorder. Prod Neurol 2003;3:204-13.
6. Mrowka M, Chaudhuri KR, Odin P. Pathophysiology of restless legs syndrome. In: Chaudhuri KR, Olanow CW, Odin P, eds. Restless legs syndrome. New York: Taylor & Francis, 2004:37-48.
7. Ondo W, Jankovic J. Restless legs syndrome: clinicoetiologic correlates. Neurology 1996;47:1435-41.
8. Montplaisir J, Boucher S, Poirier G, et al. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord 1997;12:61-5.
9. Walters AS, Hickey K, Maltzman J, et al. A questionnaire study of 138 patients with restless legs syndrome: the 'Night-Walkers' Survey. Neurology 1996;46:92-5.
10. Ondo WG, Vuong KD, Wang Q. Restless legs syndrome in monozygotic twins: clinical correlates. Neurology 2000;55:1404-6.
11. Mussio-Fournier JC, Rawak F. Familiäres Auftreten von Pruritis. Urticaria und parästhetischer Hyperkinese der unteren Extremitäten. Confin Neurol 1940;3:110-15.
12. Huizengo J. Hereditary acromyalgia or "restless legs". Acta Genet 1957;7:121-3.
13. Bornstein B. Restless legs. Psychiatr Neurol Neurochir 1961;141:165-201.
14. Montagna P, Coccagana G, Crignotta F, et al. Familial restless legs-syndrome: long-term follow-up. In: Guilleminault C, Lugaresi E, eds. Sleep/wake disorders: natural history, epidemiology, and long-term evolution. New York: Raven, 1983:231-5.
15. Winkelmann J, Muller-Myhsok B, Wittchen HU, et al. Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families. Ann Neurol 2002;52:297-302.
16. Winkelmann J, Wetter TC, Collado-Seidel V, et al. Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients. Sleep 2000;23:597-602.
17. Trenkwalder C, Seidel VC, Gasser T, et al. Clinical symptoms and possible anticipation in large kindred of familial restless legs syndrome. Mov Disord 1996;11:389-94.
18. Lazzarini A, Walters AS, Hickey K, et al. Studies of penetrance and anticipation in five autosomal-dominant restless legs syndrome pedigrees. Mov Disord 1999;14:111-16.
19. Schols L, Haan J, Riess O, et al. Sleep disturbance in spinocerebellar ataxias: is the SCA3 mutation a cause of restless legs syndrome? Neurology 1998;51:1603-7.
20. Abele M, Burk K, Laccone F, et al. Restless legs syndrome in spinocerebellar ataxia types 1, 2, and 3. J Neurol 2001;248:311-14.
21. Desautels A, Turecki G, Montplaisir J, et al. Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q. Am J Hum Genet 2001;69:1266-70.
22. Desautels A, Turecki G, Montplaisir J, et al. Restless legs syndrome: confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity. Arch Neurol 2005;62:591-6.
23. Bonati MT, Ferini-Strambi L, Aridon P, et al. Autosomal dominant restless legs syndrome maps on chromosome 14q. Brain 2003;126(Pt 6):1485-92.
24. Levchenko A, Montplaisir JY, Dubé MP, et al. The 14q restless legs syndrome locus in the French Canadian Population. Ann Neurol 2004;55:887-91.
25. Chen S, Ondo WG, Rao S, et al. Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p. Am J Hum Genet, 2004;74:876-85.
26. Desautels A, Turecki G, Montplaisir J, et al. Evidence for a genetic association between monoamine oxidase A and restless legs syndrome. Neurology 2002;59:215-19.
27. Desautels A, Turecki G, Xiong L, et al. Mutational analysis of neurotensin in familial restless legs syndrome. Mov Disord 2004;19:90-4.
28. Dichgans M, Walther E, Collado-Siedel V, et al. Autosomal dominant restless legs syndrome: genetic mode of evaluation of 22 candidate genes. Mov Disord 1996;11:87-90.
29. Desautels A, Turecki G, Montplaisir J, et al. Dopaminergic neurotransmission and restless legs syndrome: a genetic association analysis. Neurology 2001;57:1304-6.
30. Desai AV, Cherkas LF, Spector TD, et al. Genetic influences in self-reported symptoms of obstructive sleep apnoea and restless legs: a twin study. Twin Res 2004;7:589-95.