Effects of diabetes on rabbit kidney and lung CYP2E1 and CYP2B4 expression and drug metabolism and potentiation of carcinogenic activity of N-nitrosodimethylamine in kidney and lung

Food and Chemical Toxicology

Volumn 45, Issue 1, 2007, Pages 107-118

  Arinç, Emel ^a   Arslan, Şevki ^a   Bozcaarmutlu, Azra ^b   Adali, Orhan ^a  

^a MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

^b ABANT IZZET BAYSAL UNIVERSITY   (Turkey)

Author keywords

Aniline 4 hydroxylase; Benzphetamine N demethylase; CYP2B4; CYP2E1; Cytochrome P450 reductase; Diabetes; Kidney; Lung; NDMA; NDMA N demethylase; P Nitrophenol; p Nitrophenol hydroxylase; Rabbit liver

Indexed keywords

BENZPHETAMINE; CARCINOGEN; CYTOCHROME P450; CYTOCHROME P450 2B4; CYTOCHROME P450 2E1; DIMETHYLNITROSAMINE; DRUG METABOLIZING ENZYME; N DEMETHYLASE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CARCINOGENIC ACTIVITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG METABOLISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; FOOD CONTAMINATION; IMMUNOBLOTTING; IMMUNOCHEMISTRY; KIDNEY; LUNG; MALE; MICROSOME; NONHUMAN; PROTEIN EXPRESSION; RABBIT; WESTERN BLOTTING;

ALLOXAN; ANILINE HYDROXYLASE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CARCINOGENS; CYTOCHROME P-450 CYP2E1; DIABETES MELLITUS, EXPERIMENTAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INDUCTION; KIDNEY; LUNG; MALE; MICROSOMES, LIVER; NITROSAMINES; OXYGENASES; RABBITS; SPECIES SPECIFICITY;

CRICETINAE; ORYCTOLAGUS CUNICULUS;

EID: 33751209799     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.07.026     Document Type: Article

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