Hemostatic action of OC-108, a novel agent for hemorrhoids, is associated with regional blood flow arrest induced by acute inflammation

Journal of Pharmacological Sciences

Volumn 102, Issue 3, 2006, Pages 314-320

  Ono, Takashi ^a   Nakagawa, Haruto ^a   Fukunari, Atsushi ^a   Hashimoto, Toshio ^a   Komatsu, Hirotsugu ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Blood flow arrest; Hemoconcentration; Hemorrhoidal bleeding; OC 108; Vascular permeability

Indexed keywords

ALUMINUM POTASSIUM SULFATE; HEMOSTATIC AGENT; OC 108; PHENYLEPHRINE; TANNIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; BLOOD VESSEL DIAMETER; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DRUG MECHANISM; HEMATOCRIT; HEMORRHOID; HEMOSTASIS; INFLAMMATION; MALE; MICROCIRCULATION; NONHUMAN; RAT; SKIN BLOOD FLOW;

EID: 33751205066     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0060583     Document Type: Article

References (12)

1. Shi Z, Zhou J, He X. On treatment of third degree internal hemorrhoids with "Xiaozhiling" injection. J Trad Chin Med. 1981;1:115-120.
2. Shi Z. Xiaozhiling four-step injection in treating hemorrhoids of stages III and IV - a sclerotherapeutic approach of thrombosing branches of artery rectalis superior. Chin J Trad W Med. 1997;3:246-249.
3. Takamura H, Takano M, Ohba H, Fukano M, Iwadare J, Koganezawa S, et al. [Investigation of efficacy, safety and pharmacokinetics with OC-108, a novel agent for sclerosing therapy of internal hemorrhoids - early phase II study.] Jpn Pharmacol Ther. 2004;32:355-365. (text in Japanese with English abstract)
4. Takano M, Iwadare J, Ohba H, Takamura H, Masuda Y, Matsuo K, et al. Sclerosing therapy of internal hemorrhoids with a novel sclerosing agent. Comparison with ligation and excision. Int J Colorectal Dis. 2006;21:44-51.
5. Takano M, Sakaue R, Fukushima Y, Kage M. [Experimental study on the effect of sclerosing agents for hemorrhoids.] J Jpn Soc Coloproctol. 1994;47:140-151. (text in Japanese with English abstract)
6. Ono T, Goto K, Takagi S, Iwasaki S, Komatsu H. Sclerosing effect of OC-108, a novel agent for hemorrhoids, is associated with granulomatous inflammation induced by aluminum. J Pharmacol Sci. 2005;99:353-363.
7. Harada M, Takeuchi M, Fukao T, Katagiri K. A simple method for the quantitative extraction of dye extravasated into the skin. J Pharm Pharmacol. 1971;23:218-219.
8. Goligher J. Haemorrhoids or piles. In: Surgery of the anus, rectum and colon. 5th ed. London: Bailliere Tindall; 1984. p. 98-149.
9. Wilhelm DL. Inflammation and healing. In: Anderson WAD, Kissane JM, editors. Pathology. 7th ed. Saint Louis: The CV Mosby Co; 1977. p. 25-89.
10. Anderson JR. Inflammation. In: Anderson JR, editor. Muir's textbook of pathology. London: Edward Arnold; 1980. p. 43-76.
11. Osol A. Astringents and antiperspirants. In: Osol A, editor. Remington's pharmaceutical sciences. 16th ed. Easton: Mack Publishing Co; 1980. p. 720-723.
12. Schootstra R, van Driel MF, Hassankhan R, van de Werff R, Oremus ET, Uges DR, et al. The use of an alum irrigation in the treatment of massive bladder haemorrhage. Pharm Weekbl Sci. 1989;11:175-178.